{"id":"https://openalex.org/W2119013806","doi":"https://doi.org/10.1093/bioinformatics/btm437","title":"Accurate prediction of deleterious protein kinase polymorphisms","display_name":"Accurate prediction of deleterious protein kinase polymorphisms","publication_year":2007,"publication_date":"2007-09-12","ids":{"openalex":"https://openalex.org/W2119013806","doi":"https://doi.org/10.1093/bioinformatics/btm437","mag":"2119013806","pmid":"https://pubmed.ncbi.nlm.nih.gov/17855419"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm437","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm437","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/21/2918/49822625/bioinformatics_23_21_2918.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/21/2918/49822625/bioinformatics_23_21_2918.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004569243","display_name":"Ali Torkamani","orcid":"https://orcid.org/0000-0003-0232-8053"},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ali Torkamani","raw_affiliation_strings":["1 Department of Medicine and Center for Human Genetics and Genomics and 2Scripps Genomic Medicine and Department of Molecular and Experimental Medicine, The Scripps Research Institute, University of California, San Diego, La Jolla, CA 92093, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Medicine and Center for Human Genetics and Genomics and 2Scripps Genomic Medicine and Department of Molecular and Experimental Medicine, The Scripps Research Institute, University of California, San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I123431417","https://openalex.org/I4210105714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077225971","display_name":"Nicholas J. Schork","orcid":"https://orcid.org/0000-0003-0920-5013"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Schork","raw_affiliation_strings":["1 Department of Medicine and Center for Human Genetics and Genomics and 2Scripps Genomic Medicine and Department of Molecular and Experimental Medicine, The Scripps Research Institute, University of California, San Diego, La Jolla, CA 92093, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Medicine and Center for Human Genetics and Genomics and 2Scripps Genomic Medicine and Department of Molecular and Experimental Medicine, The Scripps Research Institute, University of California, San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I123431417","https://openalex.org/I4210105714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004569243"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I36258959","https://openalex.org/I4210105714"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":3.3675,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.93114251,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"21","first_page":"2918","last_page":"2925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.7103880047798157},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.5509825348854065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5462411046028137},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.532634973526001},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5302058458328247},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5233739614486694},{"id":"https://openalex.org/keywords/coding-region","display_name":"Coding region","score":0.5166087746620178},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.44593197107315063},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.42173299193382263},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.39305055141448975},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3581739068031311},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1573449671268463}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7103880047798157},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5509825348854065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5462411046028137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.532634973526001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5302058458328247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5233739614486694},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5166087746620178},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44593197107315063},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.42173299193382263},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.39305055141448975},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3581739068031311},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1573449671268463}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm437","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm437","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/21/2918/49822625/bioinformatics_23_21_2918.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17855419","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17855419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm437","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm437","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/21/2918/49822625/bioinformatics_23_21_2918.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2119013806.pdf","grobid_xml":"https://content.openalex.org/works/W2119013806.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1528656348","https://openalex.org/W1561011671","https://openalex.org/W1570448133","https://openalex.org/W1606410455","https://openalex.org/W1875580551","https://openalex.org/W1967195968","https://openalex.org/W1972038920","https://openalex.org/W1975304761","https://openalex.org/W2000559685","https://openalex.org/W2016389191","https://openalex.org/W2018211135","https://openalex.org/W2029426756","https://openalex.org/W2029820720","https://openalex.org/W2035487389","https://openalex.org/W2043696829","https://openalex.org/W2058401000","https://openalex.org/W2061008984","https://openalex.org/W2061313606","https://openalex.org/W2074370114","https://openalex.org/W2083897879","https://openalex.org/W2097558464","https://openalex.org/W2098425296","https://openalex.org/W2100988728","https://openalex.org/W2102304447","https://openalex.org/W2107305018","https://openalex.org/W2110343195","https://openalex.org/W2110863368","https://openalex.org/W2123340910","https://openalex.org/W2123943285","https://openalex.org/W2125552955","https://openalex.org/W2127230663","https://openalex.org/W2127981150","https://openalex.org/W2129559300","https://openalex.org/W2131709305","https://openalex.org/W2141481588","https://openalex.org/W2146396346","https://openalex.org/W2149618357","https://openalex.org/W2155147384","https://openalex.org/W2156241799","https://openalex.org/W2157929834","https://openalex.org/W2160782760","https://openalex.org/W2168348146","https://openalex.org/W2168909179","https://openalex.org/W2169346460","https://openalex.org/W4235237130","https://openalex.org/W4254753097","https://openalex.org/W4295216797","https://openalex.org/W6643332186","https://openalex.org/W6684463743"],"related_works":["https://openalex.org/W2335257745","https://openalex.org/W2070581548","https://openalex.org/W2391388634","https://openalex.org/W3163715263","https://openalex.org/W2383248267","https://openalex.org/W2587112589","https://openalex.org/W1997337693","https://openalex.org/W3082362785","https://openalex.org/W2133208523","https://openalex.org/W2131034894"],"abstract_inverted_index":{"We":[0,65],"have":[1,9,75],"developed":[2],"a":[3,67,76],"method":[4],"to":[5,12],"prioritize":[6],"nsSNPs":[7,73],"and":[8,28,42,60],"applied":[10],"it":[11],"the":[13],"human":[14,81],"protein":[15],"kinase":[16,72],"gene":[17],"family.":[18],"The":[19],"results":[20],"of":[21,63,70,79],"our":[22,85],"analyses":[23,41],"provide":[24,66],"high":[25],"quality":[26],"predictions":[27],"outperform":[29],"available":[30],"whole":[31],"genome":[32],"prediction":[33,38],"methods":[34,43,52],"(74%":[35],"versus":[36],"83%":[37],"accuracy).":[39],"Our":[40],"consider":[44],"both":[45],"DNA":[46],"sequence":[47],"conservation,":[48],"which":[49],"most":[50],"traditional":[51],"are":[53],"based":[54,83],"on,":[55],"as":[56],"well":[57],"unique":[58],"structural":[59],"functional":[61],"features":[62],"kinases.":[64],"ranked":[68],"list":[69],"common":[71],"that":[74],"higher":[77],"probability":[78],"impacting":[80],"disease":[82],"on":[84],"analyses.":[86]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}