{"id":"https://openalex.org/W2126704573","doi":"https://doi.org/10.1093/bioinformatics/btm322","title":"Annotation-based distance measures for patient subgroup discovery in clinical microarray studies","display_name":"Annotation-based distance measures for patient subgroup discovery in clinical microarray studies","publication_year":2007,"publication_date":"2007-06-22","ids":{"openalex":"https://openalex.org/W2126704573","doi":"https://doi.org/10.1093/bioinformatics/btm322","mag":"2126704573","pmid":"https://pubmed.ncbi.nlm.nih.gov/17586546"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/17/2256/724910/btm322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/17/2256/724910/btm322.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054494894","display_name":"Claudio Lottaz","orcid":"https://orcid.org/0000-0003-0781-4827"},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudio Lottaz","raw_affiliation_strings":["Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080966614","display_name":"Joern Toedling","orcid":"https://orcid.org/0000-0003-1471-1295"},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joern Toedling","raw_affiliation_strings":["Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003217898","display_name":"Rainer Spang","orcid":"https://orcid.org/0000-0002-1326-4297"},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Spang","raw_affiliation_strings":["Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Genetics and Berlin Center for Genome Based Bioinformatics, Ihnestr. 73, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054494894"],"corresponding_institution_ids":["https://openalex.org/I4210142260"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.2509,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.57211194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"17","first_page":"2256","last_page":"2264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10637","display_name":"Advanced Clustering Algorithms Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7648624181747437},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.6215319037437439},{"id":"https://openalex.org/keywords/bioconductor","display_name":"Bioconductor","score":0.6200641393661499},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.5046080350875854},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5004055500030518},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5001935958862305},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4862140715122223},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"Consensus clustering","score":0.48536741733551025},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48143598437309265},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.4801037609577179},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46778997778892517},{"id":"https://openalex.org/keywords/euclidean-distance","display_name":"Euclidean distance","score":0.46724724769592285},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4366624057292938},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34404516220092773},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3387059271335602},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33006051182746887},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20776265859603882},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18936029076576233},{"id":"https://openalex.org/keywords/correlation-clustering","display_name":"Correlation clustering","score":0.16259649395942688},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.10347244143486023}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7648624181747437},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.6215319037437439},{"id":"https://openalex.org/C2779694297","wikidata":"https://www.wikidata.org/wiki/Q2888953","display_name":"Bioconductor","level":3,"score":0.6200641393661499},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.5046080350875854},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5004055500030518},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5001935958862305},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4862140715122223},{"id":"https://openalex.org/C186767784","wikidata":"https://www.wikidata.org/wiki/Q5162841","display_name":"Consensus clustering","level":5,"score":0.48536741733551025},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48143598437309265},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.4801037609577179},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46778997778892517},{"id":"https://openalex.org/C120174047","wikidata":"https://www.wikidata.org/wiki/Q847073","display_name":"Euclidean distance","level":2,"score":0.46724724769592285},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4366624057292938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34404516220092773},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3387059271335602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33006051182746887},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20776265859603882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18936029076576233},{"id":"https://openalex.org/C94641424","wikidata":"https://www.wikidata.org/wiki/Q5172845","display_name":"Correlation clustering","level":3,"score":0.16259649395942688},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.10347244143486023},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/17/2256/724910/btm322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17586546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17586546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/17/2256/724910/btm322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2296969223","display_name":"Verbundprojekt: Nationales Genomforschungsnetz 2 - Genomnetz Krebs-CancerNet: Bioinformatik, Statistik und mathematische Modellierung f\u00fcr die genomische Analyse von Leuk\u00e4mien","funder_award_id":"01GS0445","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G716269372","display_name":"Verbundprojekt: Nationales Genomforschungsnetz, 2. Phase, SMP-Bioinformatik, Anteil Universit\u00e4t Regensburg","funder_award_id":"01GR0455","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126704573.pdf","grobid_xml":"https://content.openalex.org/works/W2126704573.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1493217831","https://openalex.org/W1493403933","https://openalex.org/W1493454437","https://openalex.org/W1548779692","https://openalex.org/W1551136530","https://openalex.org/W1595164952","https://openalex.org/W1611336610","https://openalex.org/W1795418937","https://openalex.org/W1886306325","https://openalex.org/W1969761972","https://openalex.org/W1977556410","https://openalex.org/W1986891966","https://openalex.org/W1991509879","https://openalex.org/W1991683565","https://openalex.org/W2000771269","https://openalex.org/W2018116321","https://openalex.org/W2025167103","https://openalex.org/W2026543586","https://openalex.org/W2071828122","https://openalex.org/W2075746486","https://openalex.org/W2082081674","https://openalex.org/W2088851040","https://openalex.org/W2097366050","https://openalex.org/W2097413644","https://openalex.org/W2100083453","https://openalex.org/W2102330962","https://openalex.org/W2102992354","https://openalex.org/W2103017472","https://openalex.org/W2105685348","https://openalex.org/W2108043112","https://openalex.org/W2110065044","https://openalex.org/W2116219421","https://openalex.org/W2117754708","https://openalex.org/W2120024428","https://openalex.org/W2122598723","https://openalex.org/W2122683221","https://openalex.org/W2124704116","https://openalex.org/W2126449841","https://openalex.org/W2127218421","https://openalex.org/W2129066856","https://openalex.org/W2130410032","https://openalex.org/W2131989143","https://openalex.org/W2137784044","https://openalex.org/W2138218344","https://openalex.org/W2141055671","https://openalex.org/W2144544802","https://openalex.org/W2146887040","https://openalex.org/W2147246240","https://openalex.org/W2150382709","https://openalex.org/W2153164260","https://openalex.org/W2153794775","https://openalex.org/W2154175938","https://openalex.org/W2157688021","https://openalex.org/W2159400887","https://openalex.org/W2160697532","https://openalex.org/W2164141804","https://openalex.org/W2168561598","https://openalex.org/W2168655003","https://openalex.org/W2170989872","https://openalex.org/W2319794630","https://openalex.org/W2582743722","https://openalex.org/W2612972698","https://openalex.org/W2999729612","https://openalex.org/W3125904670","https://openalex.org/W3152026761","https://openalex.org/W3216035567","https://openalex.org/W4229880569","https://openalex.org/W4246697467","https://openalex.org/W4255554660","https://openalex.org/W6629329278","https://openalex.org/W6632976901","https://openalex.org/W6635716314","https://openalex.org/W6636561547","https://openalex.org/W6668521591","https://openalex.org/W6674830921","https://openalex.org/W6678914141","https://openalex.org/W6682691471","https://openalex.org/W6683546621","https://openalex.org/W6804276792"],"related_works":["https://openalex.org/W2135678793","https://openalex.org/W2011682793","https://openalex.org/W2109288169","https://openalex.org/W2157684052","https://openalex.org/W4223449272","https://openalex.org/W2978247079","https://openalex.org/W2166887457","https://openalex.org/W2148708580","https://openalex.org/W2951337536","https://openalex.org/W3022399969"],"abstract_inverted_index":{"MOTIVATION:":[0],"Clustering":[1],"algorithms":[2,50],"are":[3,16,130,147,156],"widely":[4],"used":[5,103],"in":[6,98,219],"the":[7,61,68,76,83,160,207,226],"analysis":[8,77],"of":[9,22,33,109,178,194,217,232],"microarray":[10],"data.":[11,118],"In":[12,180],"clinical":[13],"studies,":[14],"they":[15],"often":[17],"applied":[18],"to":[19,60,79,104,120,142,209],"find":[20],"groups":[21],"co-regulated":[23],"genes.":[24,179],"Clustering,":[25],"however,":[26],"can":[27],"also":[28],"stratify":[29],"patients":[30,218],"by":[31,111,174],"similarity":[32],"their":[34,165],"gene":[35,100,121,124,162],"expression":[36,113],"profiles,":[37],"thereby":[38],"defining":[39],"novel":[40],"disease":[41],"entities":[42],"based":[43],"on":[44,237],"molecular":[45],"characteristics.":[46],"Several":[47],"distance-based":[48],"cluster":[49],"have":[51,184],"been":[52,58],"suggested,":[53],"but":[54],"little":[55],"attention":[56],"has":[57,206],"given":[59],"distance":[62,137],"measure":[63,138],"between":[64,82,139],"patients.":[65],"Even":[66],"with":[67,126,159],"Euclidean":[69],"metric,":[70],"including":[71],"and":[72,86,115,164,236],"excluding":[73],"genes":[74,195],"from":[75],"leads":[78],"different":[80,88,136,143],"distances":[81],"same":[84],"objects,":[85],"consequently":[87],"clustering":[89,96],"results.":[90],"RESULTS:":[91],"We":[92,201,224],"describe":[93],"a":[94,135,150],"new":[95,199],"algorithm,":[97],"which":[99],"selection":[101],"is":[102],"derive":[105],"biologically":[106,175,191],"meaningful":[107],"clusterings":[108,146,155,172],"samples":[110],"combining":[112],"profiles":[114],"functional":[116,128,166],"annotation":[117],"According":[119],"annotations,":[122],"candidate":[123],"sets":[125,163,177,193],"specific":[127],"characterizations":[129],"generated.":[131],"Each":[132],"set":[133],"defines":[134],"patients,":[140],"leading":[141],"clusterings.":[144],"These":[145],"filtered":[148],"using":[149],"resampling-based":[151],"significance":[152],"measure.":[153],"Significant":[154],"reported":[157],"together":[158],"underlying":[161],"definition.":[167],"CONCLUSIONS:":[168],"Our":[169],"method":[170,205],"reports":[171],"defined":[173],"focused":[176],"annotation-driven":[181],"clusterings,":[182],"we":[183],"recovered":[185],"clinically":[186,214],"relevant":[187,215],"patient":[188],"subgroups":[189],"through":[190],"plausible":[192],"as":[196,198,230],"well":[197],"subgroupings.":[200],"conjecture":[202],"that":[203],"our":[204],"potential":[208],"reveal":[210],"so":[211],"far":[212],"unknown,":[213],"classes":[216],"an":[220],"unsupervised":[221],"manner.":[222],"AVAILABILITY:":[223],"provide":[225],"R":[227],"package":[228],"adSplit":[229],"part":[231],"Bioconductor":[233],"release":[234],"1.9":[235],"http://compdiag.molgen.mpg.de/software.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-19T15:00:24.278416","created_date":"2025-10-10T00:00:00"}