{"id":"https://openalex.org/W2160517420","doi":"https://doi.org/10.1093/bioinformatics/btm188","title":"Structural templates predict novel protein interactions and targets from pancreas tumour gene expression data","display_name":"Structural templates predict novel protein interactions and targets from pancreas tumour gene expression data","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2160517420","doi":"https://doi.org/10.1093/bioinformatics/btm188","mag":"2160517420","pmid":"https://pubmed.ncbi.nlm.nih.gov/17646287"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm188","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/i115/23705771/btm188.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/i115/23705771/btm188.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079122835","display_name":"Gihan Dawelbait","orcid":null},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gihan Dawelbait","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087926275","display_name":"Christof Winter","orcid":"https://orcid.org/0000-0002-0253-9056"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christof Winter","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101575637","display_name":"Yanju Zhang","orcid":"https://orcid.org/0000-0002-8629-258X"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yanju Zhang","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014489598","display_name":"Christian Pilarsky","orcid":"https://orcid.org/0000-0002-7968-3283"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Pilarsky","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008757972","display_name":"Robert Gr\u00fctzmann","orcid":"https://orcid.org/0000-0003-2559-0476"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Gr\u00fctzmann","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031294867","display_name":"J\u00f6rg\u2010Christian Heinrich","orcid":null},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg-Christian Heinrich","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016411406","display_name":"Michael Schroeder","orcid":"https://orcid.org/0000-0003-2848-6949"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schroeder","raw_affiliation_strings":["1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics Group, Biotechnological Centre, TU Dresden, Dresden, Germany, 2Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany and 3RESprotect GmbH, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079122835"],"corresponding_institution_ids":["https://openalex.org/I78650965"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.3453,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.80111764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"23","issue":"13","first_page":"i115","last_page":"i124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.6446184515953064},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6422926783561707},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.551873505115509},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.49296140670776367},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.48757094144821167},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.4703769087791443},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.46450066566467285},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44877564907073975},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.44610610604286194},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.42850080132484436},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.34516605734825134},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.225832998752594}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6446184515953064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6422926783561707},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.551873505115509},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.49296140670776367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48757094144821167},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4703769087791443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46450066566467285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44877564907073975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44610610604286194},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42850080132484436},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34516605734825134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.225832998752594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm188","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/i115/23705771/btm188.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17646287","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17646287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm188","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/i115/23705771/btm188.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6800000071525574}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160517420.pdf","grobid_xml":"https://content.openalex.org/works/W2160517420.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W10855956","https://openalex.org/W43051898","https://openalex.org/W1506497999","https://openalex.org/W1581900567","https://openalex.org/W1963482182","https://openalex.org/W1967408543","https://openalex.org/W1982956208","https://openalex.org/W1983995085","https://openalex.org/W1988422871","https://openalex.org/W1993826818","https://openalex.org/W1994803330","https://openalex.org/W2001321108","https://openalex.org/W2002355858","https://openalex.org/W2007025436","https://openalex.org/W2010168796","https://openalex.org/W2011387381","https://openalex.org/W2018851438","https://openalex.org/W2024466061","https://openalex.org/W2031819782","https://openalex.org/W2034269086","https://openalex.org/W2037036397","https://openalex.org/W2040941311","https://openalex.org/W2044229333","https://openalex.org/W2044514479","https://openalex.org/W2044946603","https://openalex.org/W2050721857","https://openalex.org/W2055718828","https://openalex.org/W2057885377","https://openalex.org/W2060630781","https://openalex.org/W2065304353","https://openalex.org/W2069075820","https://openalex.org/W2083978969","https://openalex.org/W2084619201","https://openalex.org/W2085277871","https://openalex.org/W2085836120","https://openalex.org/W2088498795","https://openalex.org/W2095554214","https://openalex.org/W2095643532","https://openalex.org/W2095805667","https://openalex.org/W2099023480","https://openalex.org/W2099862356","https://openalex.org/W2100371004","https://openalex.org/W2103017472","https://openalex.org/W2104315543","https://openalex.org/W2108862316","https://openalex.org/W2108909942","https://openalex.org/W2113019448","https://openalex.org/W2113386816","https://openalex.org/W2114399285","https://openalex.org/W2114520383","https://openalex.org/W2120386856","https://openalex.org/W2120736575","https://openalex.org/W2123280311","https://openalex.org/W2124277850","https://openalex.org/W2127101082","https://openalex.org/W2130479394","https://openalex.org/W2130675570","https://openalex.org/W2132788187","https://openalex.org/W2133872562","https://openalex.org/W2134528192","https://openalex.org/W2134672568","https://openalex.org/W2135805255","https://openalex.org/W2137607173","https://openalex.org/W2140618597","https://openalex.org/W2140798893","https://openalex.org/W2144483796","https://openalex.org/W2145173401","https://openalex.org/W2147714160","https://openalex.org/W2147736120","https://openalex.org/W2149628033","https://openalex.org/W2150981663","https://openalex.org/W2152281406","https://openalex.org/W2152551546","https://openalex.org/W2153577994","https://openalex.org/W2154164444","https://openalex.org/W2155320925","https://openalex.org/W2155723007","https://openalex.org/W2159460045","https://openalex.org/W2165674132","https://openalex.org/W2167869241","https://openalex.org/W2168549338","https://openalex.org/W2172049947","https://openalex.org/W2328331914","https://openalex.org/W4252706339","https://openalex.org/W4255855797","https://openalex.org/W6658588649","https://openalex.org/W6667518242","https://openalex.org/W6674503074","https://openalex.org/W6681219405","https://openalex.org/W6683174123"],"related_works":["https://openalex.org/W2801632896","https://openalex.org/W2043890160","https://openalex.org/W2582912872","https://openalex.org/W2337680646","https://openalex.org/W3021125337","https://openalex.org/W2086968193","https://openalex.org/W2728479436","https://openalex.org/W3173207637","https://openalex.org/W1499339123","https://openalex.org/W3152727146"],"abstract_inverted_index":{"MOTIVATION:":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"eludes":[5],"early":[6],"detection":[7],"and":[8,14,41,76,101,160,195],"is":[9,148,190],"characterized":[10],"by":[11,70,77],"its":[12,164,216],"aggressiveness":[13],"resistance":[15],"to":[16,29,49,52,67,89,192,208],"current":[17],"therapies.":[18],"A":[19],"number":[20],"of":[21,110,158,163,181,187,199,212],"gene":[22],"expression":[23],"screens":[24],"have":[25,46],"been":[26,47],"carried":[27],"out":[28],"identify":[30,38],"genes":[31,45],"differentially":[32],"expressed":[33],"in":[34,118,150,172,218],"cancerous":[35],"tissue.":[36],"To":[37],"molecular":[39],"markers":[40],"suitable":[42],"targets,":[43],"these":[44],"mapped":[48],"protein":[50,80],"interactions":[51,75,81,129],"gain":[53],"an":[54,115,169,185],"understanding":[55],"at":[56,226],"systems":[57],"level.":[58],"RESULTS:":[59],"Here,":[60],"we":[61,87,153,176],"take":[62],"such":[63],"a":[64],"network-centric":[65],"approach":[66],"pancreas":[68],"cancer":[69],"re-constructing":[71],"networks":[72],"from":[73,82],"known":[74,191],"predicting":[78],"novel":[79,128],"structural":[83,123],"templates.":[84],"The":[85],"pathways":[86],"find":[88],"be":[90],"largely":[91],"affected":[92],"are":[93,224],"signal":[94],"transduction,":[95],"actin":[96],"cytoskeleton":[97],"regulation,":[98],"cell":[99,102],"growth":[100],"communication.":[103],"Our":[104,201],"analysis":[105],"indicates":[106],"that":[107,155,204],"the":[108,111,131,140,156,161,178,197,209],"alteration":[109],"calcium":[112],"pathway":[113,134],"plays":[114,168],"important":[116,170],"role":[117,171,180],"pancreas-specific":[119],"tumorigenesis.":[120],"Furthermore,":[121],"our":[122],"prediction":[124],"method":[125],"identifies":[126],"40":[127],"including":[130],"tissue":[132],"factor":[133],"inhibitor":[135,166,186],"2":[136],"(TFPI2)":[137],"interacting":[138],"with":[139],"transmembrane":[141],"protease":[142],"serine":[143],"4":[144],"(TMPRSS4).":[145],"Since":[146],"TMPRSS4":[147,159],"involved":[149],"metastasis":[151],"formation,":[152],"hypothesize":[154],"upregulation":[157],"downregulation":[162],"predicted":[165],"TFPI2":[167],"this":[173],"process.":[174],"Moreover,":[175],"examine":[177],"potential":[179],"BVDU":[182,205],"(RP101)":[183],"as":[184],"TMPRSS4.":[188],"BDVU":[189],"support":[193],"apoptosis":[194],"prevent":[196],"acquisition":[198],"chemoresistance.":[200],"results":[202],"suggest":[203],"might":[206],"bind":[207],"active":[210],"site":[211],"TMPRSS4,":[213],"thus":[214],"reducing":[215],"assistance":[217],"metastasis.":[219],"SUPPLEMENTARY":[220],"INFORMATION:":[221],"Supplementary":[222],"data":[223],"available":[225],"Bioinformatics":[227],"online.":[228]},"counts_by_year":[{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}