{"id":"https://openalex.org/W2099235429","doi":"https://doi.org/10.1093/bioinformatics/btm151","title":"Time-varying modeling of gene expression regulatory networks using the wavelet dynamic vector autoregressive method","display_name":"Time-varying modeling of gene expression regulatory networks using the wavelet dynamic vector autoregressive method","publication_year":2007,"publication_date":"2007-04-26","ids":{"openalex":"https://openalex.org/W2099235429","doi":"https://doi.org/10.1093/bioinformatics/btm151","mag":"2099235429","pmid":"https://pubmed.ncbi.nlm.nih.gov/17463021"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm151","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm151","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/1623/23704060/btm151.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/1623/23704060/btm151.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067767544","display_name":"Andr\u00e9 Fujita","orcid":"https://orcid.org/0000-0002-7756-7051"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. Fujita","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029606860","display_name":"Jo\u00e3o Ricardo Sato","orcid":"https://orcid.org/0000-0002-7503-9781"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J.R. Sato","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083415861","display_name":"Miguel Garay-Malpartida","orcid":"https://orcid.org/0000-0002-1164-2055"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"H.M. Garay-Malpartida","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079320411","display_name":"Pedro A. Morettin","orcid":"https://orcid.org/0000-0002-8611-867X"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P.A. Morettin","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036266784","display_name":"Mari Cleide Sogayar","orcid":"https://orcid.org/0000-0003-4805-4609"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M.C. Sogayar","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103212438","display_name":"Carlos Eduardo Ferreira","orcid":"https://orcid.org/0000-0003-4804-5788"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"C.E. Ferreira","raw_affiliation_strings":["1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Mathematics and Statistics, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010 \u2013 S\u00e3o Paulo, 05508-090, SP, Brazil and 2Chemistry Institute, University of S\u00e3o Paulo, Cell and Molecular Biology Laboratory, Av. Lineu Prestes, 748 \u2013 S\u00e3o Paulo, 05508-900, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103212438"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":3.634,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93687265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"13","first_page":"1623","last_page":"1630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7091000080108643,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7091000080108643,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.17649999260902405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7485426068305969},{"id":"https://openalex.org/keywords/autoregressive-model","display_name":"Autoregressive model","score":0.6456860303878784},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5607135891914368},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4747477173805237},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.458029568195343},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.45791569352149963},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4464018642902374},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4404563307762146},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.433589369058609},{"id":"https://openalex.org/keywords/granger-causality","display_name":"Granger causality","score":0.4308048188686371},{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.4135763645172119},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3757916986942291},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3279059827327728},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2945559024810791},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2432575821876526},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16266405582427979},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.15492072701454163}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7485426068305969},{"id":"https://openalex.org/C159877910","wikidata":"https://www.wikidata.org/wiki/Q2202883","display_name":"Autoregressive model","level":2,"score":0.6456860303878784},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5607135891914368},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4747477173805237},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.458029568195343},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.45791569352149963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4464018642902374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4404563307762146},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.433589369058609},{"id":"https://openalex.org/C129824826","wikidata":"https://www.wikidata.org/wiki/Q2630107","display_name":"Granger causality","level":2,"score":0.4308048188686371},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.4135763645172119},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3757916986942291},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3279059827327728},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2945559024810791},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2432575821876526},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16266405582427979},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.15492072701454163},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm151","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm151","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/1623/23704060/btm151.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17463021","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17463021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm151","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm151","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/13/1623/23704060/btm151.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099235429.pdf","grobid_xml":"https://content.openalex.org/works/W2099235429.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W143485405","https://openalex.org/W297455914","https://openalex.org/W1756428283","https://openalex.org/W1893505266","https://openalex.org/W1981547652","https://openalex.org/W1986040959","https://openalex.org/W2008662004","https://openalex.org/W2014111929","https://openalex.org/W2014630371","https://openalex.org/W2015519364","https://openalex.org/W2028329161","https://openalex.org/W2028969135","https://openalex.org/W2033988020","https://openalex.org/W2044646840","https://openalex.org/W2057271298","https://openalex.org/W2064474659","https://openalex.org/W2081923855","https://openalex.org/W2090554117","https://openalex.org/W2092160559","https://openalex.org/W2098914003","https://openalex.org/W2101567517","https://openalex.org/W2105712639","https://openalex.org/W2110065044","https://openalex.org/W2117994680","https://openalex.org/W2118467699","https://openalex.org/W2120034091","https://openalex.org/W2125631472","https://openalex.org/W2148460690","https://openalex.org/W2149640683","https://openalex.org/W2155757556","https://openalex.org/W2168399023","https://openalex.org/W2171804041","https://openalex.org/W2178225550","https://openalex.org/W2313281565","https://openalex.org/W2326537533","https://openalex.org/W2610714868","https://openalex.org/W2611370172","https://openalex.org/W3137970571","https://openalex.org/W6605798829","https://openalex.org/W6661841633","https://openalex.org/W6673567362","https://openalex.org/W6682639370","https://openalex.org/W6685380154"],"related_works":["https://openalex.org/W126301054","https://openalex.org/W4251195004","https://openalex.org/W4242807451","https://openalex.org/W2127540830","https://openalex.org/W2035792466","https://openalex.org/W2977645287","https://openalex.org/W4251418261","https://openalex.org/W1972675643","https://openalex.org/W2154758532","https://openalex.org/W1982897783"],"abstract_inverted_index":{"MOTIVATION:":[0],"A":[1],"variety":[2,11],"of":[3,12,24,34,168,191],"biological":[4,93,164],"cellular":[5],"processes":[6,29],"are":[7],"achieved":[8],"through":[9],"a":[10,49,91,121],"extracellular":[13],"regulators,":[14],"signal":[15],"transduction,":[16],"protein-protein":[17],"interactions":[18],"and":[19,37,176,189],"differential":[20],"gene":[21,38,55,71,138,143,157,170],"expression.":[22],"Understanding":[23],"the":[25,35,75,78,104,115,130,186,192],"mechanisms":[26],"underlying":[27],"these":[28,44,124,196],"requires":[30],"detailed":[31],"molecular":[32,45],"description":[33],"protein":[36],"networks":[39,57,73,140,172],"involved.":[40],"To":[41],"better":[42],"understand":[43],"networks,":[46],"we":[47,113,181],"propose":[48],"statistical":[50],"method":[51],"to":[52,102,123,135,184],"estimate":[53,136],"time-varying":[54,137],"regulatory":[56,72,139,171],"from":[58,147],"time":[59,105],"series":[60],"microarray":[61,148],"data.":[62],"One":[63],"well":[64],"known":[65],"problem":[66],"when":[67],"inferring":[68,87],"connectivity":[69],"in":[70,195],"is":[74,95,99,152],"fact":[76],"that":[77,83],"relationships":[79],"found":[80,204],"constitute":[81],"correlations":[82],"do":[84],"not":[85],"allow":[86],"causation,":[88],"for":[89,178],"which,":[90],"priori":[92],"knowledge":[94],"required.":[96],"Moreover,":[97],"it":[98],"also":[100],"necessary":[101],"know":[103],"period":[106],"at":[107,205],"which":[108],"this":[109],"causation":[110],"occurs.":[111],"Here,":[112],"present":[114],"Dynamic":[116,131],"Vector":[117,132],"Autoregressive":[118,133],"model":[119,134],"as":[120],"solution":[122],"problems.":[125],"RESULTS:":[126],"We":[127],"have":[128],"applied":[129],"based":[141,155],"on":[142,156],"expression":[144,158],"profiles":[145,159],"obtained":[146],"experiments.":[149],"The":[150],"network":[151],"determined":[153],"entirely":[154],"data,":[160],"without":[161],"any":[162],"prior":[163],"knowledge.":[165],"Through":[166],"construction":[167],"three":[169],"(of":[173],"p53,":[174],"NF-kappaB":[175],"c-myc)":[177],"HeLa":[179],"cells,":[180],"were":[182],"able":[183],"predict":[185],"connectivity,":[187],"Granger-causality":[188],"dynamics":[190],"information":[193],"flow":[194],"networks.":[197],"SUPPLEMENTARY":[198],"INFORMATION:":[199],"Additional":[200],"figures":[201],"may":[202],"be":[203],"http://mariwork.iq.usp.br/dvar/.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}