{"id":"https://openalex.org/W2123592990","doi":"https://doi.org/10.1093/bioinformatics/btm044","title":"Simulating Epstein-Barr virus infection with C-ImmSim","display_name":"Simulating Epstein-Barr virus infection with C-ImmSim","publication_year":2007,"publication_date":"2007-03-06","ids":{"openalex":"https://openalex.org/W2123592990","doi":"https://doi.org/10.1093/bioinformatics/btm044","mag":"2123592990","pmid":"https://pubmed.ncbi.nlm.nih.gov/17341499"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm044","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/11/1371/49812811/bioinformatics_23_11_1371.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/11/1371/49812811/bioinformatics_23_11_1371.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010454141","display_name":"Filippo Castiglione","orcid":"https://orcid.org/0000-0002-1442-3552"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filippo Castiglione","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003876945","display_name":"Karen Duca","orcid":null},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Duca","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083154892","display_name":"Abdul Salam Jarrah","orcid":"https://orcid.org/0000-0001-6771-2561"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Jarrah","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091010756","display_name":"Reinhard Laubenbacher","orcid":"https://orcid.org/0000-0002-9143-9451"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhard Laubenbacher","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058173067","display_name":"Donna Hochberg","orcid":null},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Hochberg","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110186330","display_name":"David A. Thorley\u2010Lawson","orcid":null},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Thorley-Lawson","raw_affiliation_strings":["1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Istituto Applicazioni del Calcolo (IAC) \u201cM. Picone\u201d-CNR, Viale del Policlinico, 137, 00161 \u2013 Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110186330"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I859038795"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.8578,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.91416747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"23","issue":"11","first_page":"1371","last_page":"1377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.6502000093460083,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.6502000093460083,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"Immunosurveillance","score":0.763660728931427},{"id":"https://openalex.org/keywords/clearance","display_name":"Clearance","score":0.639447808265686},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.6003308892250061},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5876864194869995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43872976303100586},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.34550565481185913},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.25018447637557983},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23981621861457825}],"concepts":[{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.763660728931427},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.639447808265686},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6003308892250061},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5876864194869995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43872976303100586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34550565481185913},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25018447637557983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23981621861457825},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm044","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/11/1371/49812811/bioinformatics_23_11_1371.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17341499","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17341499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm044","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/11/1371/49812811/bioinformatics_23_11_1371.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1021994297","display_name":null,"funder_award_id":"R01 AI062989","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1754444808","display_name":null,"funder_award_id":"R01 AI18757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2828391368","display_name":null,"funder_award_id":"R01 CA65883","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332749","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1607982202","https://openalex.org/W1979401674","https://openalex.org/W1981932944","https://openalex.org/W1990507981","https://openalex.org/W2000869574","https://openalex.org/W2013141236","https://openalex.org/W2024161489","https://openalex.org/W2057154903","https://openalex.org/W2074107830","https://openalex.org/W2074795687","https://openalex.org/W2077910054","https://openalex.org/W2079053367","https://openalex.org/W2081021502","https://openalex.org/W2086370911","https://openalex.org/W2116449651","https://openalex.org/W2123029438","https://openalex.org/W2151633047","https://openalex.org/W6669785307"],"related_works":["https://openalex.org/W2912064558","https://openalex.org/W2016551366","https://openalex.org/W2188759708","https://openalex.org/W2138564085","https://openalex.org/W2123163123","https://openalex.org/W2147145791","https://openalex.org/W2111970140","https://openalex.org/W4386371748","https://openalex.org/W1874513932","https://openalex.org/W2094230406"],"abstract_inverted_index":{"MOTIVATION:":[0],"Epstein-Barr":[1],"virus":[2],"(EBV)":[3],"infects":[4],"greater":[5],"than":[6],"90%":[7],"of":[8,58,69,81,91,107,126,138],"humans":[9],"benignly":[10],"for":[11],"life":[12],"but":[13],"can":[14],"be":[15],"associated":[16],"with":[17],"tumors.":[18],"It":[19],"is":[20,26,33,102,131,140,149],"a":[21,42,59,92],"uniquely":[22],"human":[23,51],"pathogen":[24],"that":[25,101],"amenable":[27],"to":[28,45,66,85,98,112,121],"quantitative":[29],"analysis;":[30],"however,":[31],"there":[32],"no":[34],"applicable":[35],"animal":[36],"model.":[37],"Computer":[38],"models":[39],"may":[40],"provide":[41],"virtual":[43],"environment":[44],"perform":[46],"experiments":[47],"not":[48,119],"possible":[49],"in":[50,75],"volunteers.":[52],"RESULTS:":[53],"We":[54],"report":[55],"the":[56,67,76,89,113,124,129,143],"application":[57],"relatively":[60],"simple":[61],"stochastic":[62],"cellular":[63],"automaton":[64],"(C-ImmSim)":[65],"modeling":[68],"EBV":[70],"infection.":[71],"Infected":[72],"B-cell":[73],"dynamics":[74],"acute":[77],"and":[78,148],"chronic":[79],"phases":[80],"infection":[82,96,130],"correspond":[83],"well":[84],"clinical":[86],"data":[87],"including":[88],"establishment":[90],"long":[93],"term":[94],"persistent":[95],"(up":[97],"10":[99],"years)":[100],"absolutely":[103],"dependent":[104],"on":[105],"access":[106],"latently":[108],"infected":[109],"B":[110],"cells":[111],"peripheral":[114],"pool":[115],"where":[116],"they":[117],"are":[118],"subject":[120],"immunosurveillance.":[122],"In":[123],"absence":[125],"this":[127],"compartment":[128],"cleared.":[132],"AVAILABILITY:":[133],"The":[134],"latest":[135],"version":[136],"6":[137],"C-ImmSim":[139],"available":[141],"under":[142],"GNU":[144],"General":[145],"Public":[146],"License":[147],"downloadable":[150],"from":[151],"www.iac.cnr.it/~filippo/cimmsim.html":[152]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}