{"id":"https://openalex.org/W2125936043","doi":"https://doi.org/10.1093/bioinformatics/btl661","title":"Structure-based evaluation of<i>in silico</i>predictions of protein\u2013protein interactions using Comparative Docking","display_name":"Structure-based evaluation of<i>in silico</i>predictions of protein\u2013protein interactions using Comparative Docking","publication_year":2007,"publication_date":"2007-01-18","ids":{"openalex":"https://openalex.org/W2125936043","doi":"https://doi.org/10.1093/bioinformatics/btl661","mag":"2125936043","pmid":"https://pubmed.ncbi.nlm.nih.gov/17237047"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl661","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl661","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049863628","display_name":"Simon Cockell","orcid":"https://orcid.org/0000-0002-6831-9806"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Simon J. Cockell","raw_affiliation_strings":["1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840557","display_name":"Baldo Oliva","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Baldo Oliva","raw_affiliation_strings":["1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015550435","display_name":"Richard M. Jackson","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Richard M. Jackson","raw_affiliation_strings":["1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom and 2Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.6151,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.82836207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"23","issue":"5","first_page":"573","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.48840001225471497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.48840001225471497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8047378063201904},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6472342610359192},{"id":"https://openalex.org/keywords/soundness","display_name":"Soundness","score":0.540364682674408},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5222852230072021},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5110374689102173},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.47441408038139343},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4420568346977234},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.43308377265930176},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42766910791397095},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.42713603377342224},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.32864052057266235},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1978606879711151},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.181954026222229},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09888964891433716}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8047378063201904},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6472342610359192},{"id":"https://openalex.org/C39920170","wikidata":"https://www.wikidata.org/wiki/Q693083","display_name":"Soundness","level":2,"score":0.540364682674408},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5222852230072021},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5110374689102173},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.47441408038139343},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4420568346977234},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.43308377265930176},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42766910791397095},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.42713603377342224},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.32864052057266235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1978606879711151},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.181954026222229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09888964891433716},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008058","descriptor_name":"Dihydrolipoamide Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008058","descriptor_name":"Dihydrolipoamide Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008058","descriptor_name":"Dihydrolipoamide Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016948","descriptor_name":"Azotobacter vinelandii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016948","descriptor_name":"Azotobacter vinelandii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016948","descriptor_name":"Azotobacter vinelandii","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl661","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl661","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17237047","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17237047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1534476081","https://openalex.org/W1550712876","https://openalex.org/W1570362997","https://openalex.org/W1595347157","https://openalex.org/W1679367724","https://openalex.org/W1884509322","https://openalex.org/W1974156712","https://openalex.org/W1977186059","https://openalex.org/W1988422871","https://openalex.org/W1990547107","https://openalex.org/W1995117714","https://openalex.org/W2011235285","https://openalex.org/W2015461045","https://openalex.org/W2037036397","https://openalex.org/W2045131140","https://openalex.org/W2057885377","https://openalex.org/W2060809301","https://openalex.org/W2062327179","https://openalex.org/W2065304353","https://openalex.org/W2079988374","https://openalex.org/W2080922074","https://openalex.org/W2083978969","https://openalex.org/W2084619201","https://openalex.org/W2099862356","https://openalex.org/W2105321472","https://openalex.org/W2111397525","https://openalex.org/W2113654464","https://openalex.org/W2124463526","https://openalex.org/W2125725297","https://openalex.org/W2127637605","https://openalex.org/W2128888818","https://openalex.org/W2130280638","https://openalex.org/W2130479394","https://openalex.org/W2130687290","https://openalex.org/W2131736388","https://openalex.org/W2132926880","https://openalex.org/W2141652419","https://openalex.org/W2146312020","https://openalex.org/W2147736120","https://openalex.org/W2148676725","https://openalex.org/W2151831732","https://openalex.org/W2160223331","https://openalex.org/W2161062388","https://openalex.org/W2161574105","https://openalex.org/W2166020074","https://openalex.org/W2167869241","https://openalex.org/W2168909179","https://openalex.org/W4233751197","https://openalex.org/W4240921265","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W2946599741","https://openalex.org/W3187431608","https://openalex.org/W2593264178","https://openalex.org/W2043066834","https://openalex.org/W3171039768","https://openalex.org/W1974422922","https://openalex.org/W2136856901","https://openalex.org/W2368468053","https://openalex.org/W1741740882","https://openalex.org/W2035942032"],"abstract_inverted_index":{"MOTIVATION:":[0],"Due":[1],"to":[2,24,46,55,63,189],"the":[3,18,26,78,86,98,109,119,135,143,147,172,179,183],"limitations":[4],"in":[5,52,85,88,93,102,160],"experimental":[6,64],"methods":[7],"for":[8,21,142],"determining":[9],"binary":[10],"interactions":[11,153,180],"and":[12,33,101,163,185],"structure":[13],"determination":[14],"of":[15,51,80,95,104,118,137,165,178,195,199],"protein":[16,34,81],"complexes,":[17],"need":[19],"exists":[20],"computational":[22],"models":[23,45,140],"fill":[25],"increasing":[27],"gap":[28],"between":[29],"genome":[30],"sequence":[31,105],"information":[32],"annotation.":[35],"Here":[36],"we":[37],"describe":[38],"a":[39,48,56,74,128,191],"novel":[40],"method":[41,76],"that":[42,60,116],"uses":[43],"structural":[44],"reduce":[47],"large":[49],"number":[50],"silico":[53,89],"predictions":[54],"high":[57,192],"confidence":[58,193],"subset":[59],"is":[61],"amenable":[62],"validation.":[65],"RESULTS:":[66],"A":[67],"two-stage":[68],"evaluation":[69,132],"procedure":[70,133],"was":[71,114],"developed,":[72],"first,":[73],"sequence-based":[75],"assessed":[77,123,134],"conservation":[79],"interface":[82],"patches":[83],"used":[84],"original":[87],"prediction":[90],"method,":[91],"both":[92,182],"terms":[94,103],"position":[96],"within":[97],"primary":[99],"sequence,":[100],"conservation.":[106],"When":[107],"applying":[108],"most":[110],"stringent":[111],"conditions":[112],"it":[113],"found":[115],"20.5%":[117],"data":[120,148,208],"set":[121,149,194],"being":[122,150],"passed":[124,181],"this":[125,161],"test.":[126],"Secondly,":[127],"high-throughput":[129],"structure-based":[130],"docking":[131],"soundness":[136],"three":[138],"dimensional":[139],"produced":[141],"putative":[144],"interactions.":[145],"Of":[146],"assessed,":[151],"8264":[152],"or":[154],"over":[155],"70%":[156],"could":[157],"be":[158,168,187,190],"modelled":[159],"way,":[162],"27%":[164],"these":[166],"can":[167,186],"considered":[169,188],"'valid'":[170],"by":[171],"applied":[173],"criteria.":[174],"In":[175],"all,":[176],"6.9%":[177],"tests":[184],"predicted":[196],"interactions,":[197],"several":[198],"which":[200],"are":[201,209],"described.":[202],"AVAILABILITY:":[203],"http://bioinformatics.leeds.ac.uk/~bmb4sjc.":[204],"SUPPLEMENTARY":[205],"INFORMATION:":[206],"Supplementary":[207],"available":[210],"at":[211],"Bioinformatics":[212],"online.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2016-06-24T00:00:00"}