{"id":"https://openalex.org/W2136834693","doi":"https://doi.org/10.1093/bioinformatics/btl432","title":"Few crucial links assure checkpoint efficiency in the yeast cell-cycle network","display_name":"Few crucial links assure checkpoint efficiency in the yeast cell-cycle network","publication_year":2006,"publication_date":"2006-08-07","ids":{"openalex":"https://openalex.org/W2136834693","doi":"https://doi.org/10.1093/bioinformatics/btl432","mag":"2136834693","pmid":"https://pubmed.ncbi.nlm.nih.gov/16895923"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl432","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl432","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2539/18529554/btl432.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2539/18529554/btl432.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063687089","display_name":"Gautier Stoll","orcid":"https://orcid.org/0000-0002-0862-4139"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gautier Stoll","raw_affiliation_strings":["Swiss Institute of Experimental Cancer Research, ISREC, NCCR Molecular Oncology 1 \u00a0 1 \u00a0 \u00a0 CH-1066 Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Institute of Experimental Cancer Research, ISREC, NCCR Molecular Oncology 1 \u00a0 1 \u00a0 \u00a0 CH-1066 Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008872013","display_name":"Jacques Rougemont","orcid":"https://orcid.org/0000-0002-0955-606X"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jacques Rougemont","raw_affiliation_strings":["Swiss Institute of Bioinformatics, SIB 3 \u00a0 3 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Institute of Bioinformatics, SIB 3 \u00a0 3 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045537456","display_name":"F\u00e9lix Naef","orcid":"https://orcid.org/0000-0001-9786-3037"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"F\u00e9lix Naef","raw_affiliation_strings":["Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, School of Life Sciences 2 \u00a0 2 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland","Swiss Institute of Bioinformatics, SIB 3 \u00a0 3 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland","Swiss Institute of Experimental Cancer Research, ISREC, NCCR Molecular Oncology 1 \u00a0 1 \u00a0 \u00a0 CH-1066 Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, School of Life Sciences 2 \u00a0 2 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, SIB 3 \u00a0 3 \u00a0 \u00a0 CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Swiss Institute of Experimental Cancer Research, ISREC, NCCR Molecular Oncology 1 \u00a0 1 \u00a0 \u00a0 CH-1066 Epalinges, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045537456"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I5124864"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.9541,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73650951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"20","first_page":"2539","last_page":"2546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7900999784469604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7900999784469604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6883962154388428},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5260757803916931},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.4911472499370575},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint","display_name":"Cell cycle checkpoint","score":0.4674893915653229},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4291854500770569},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3249209523200989},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2634459435939789},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.16515740752220154},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1634000837802887},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1309736669063568}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6883962154388428},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5260757803916931},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4911472499370575},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4674893915653229},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4291854500770569},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3249209523200989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2634459435939789},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16515740752220154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1634000837802887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1309736669063568},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btl432","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl432","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2539/18529554/btl432.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16895923","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16895923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:doc.rero.ch:291072","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:infoscience.epfl.ch:154030","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/154030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btl432","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl432","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2539/18529554/btl432.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136834693.pdf","grobid_xml":"https://content.openalex.org/works/W2136834693.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W72928827","https://openalex.org/W1557270760","https://openalex.org/W1575619134","https://openalex.org/W1971727132","https://openalex.org/W1978319180","https://openalex.org/W2029217862","https://openalex.org/W2037992356","https://openalex.org/W2046340617","https://openalex.org/W2047533536","https://openalex.org/W2047674748","https://openalex.org/W2052561372","https://openalex.org/W2053961182","https://openalex.org/W2065782501","https://openalex.org/W2069144966","https://openalex.org/W2072159031","https://openalex.org/W2076453831","https://openalex.org/W2086038326","https://openalex.org/W2099325822","https://openalex.org/W2102263388","https://openalex.org/W2102787760","https://openalex.org/W2115260641","https://openalex.org/W2139374901","https://openalex.org/W2150114634","https://openalex.org/W2150750144","https://openalex.org/W2150767223","https://openalex.org/W2160145365","https://openalex.org/W2160533336","https://openalex.org/W2171280873","https://openalex.org/W2397944365","https://openalex.org/W3008437073"],"related_works":["https://openalex.org/W1972085353","https://openalex.org/W1995228374","https://openalex.org/W3107603624","https://openalex.org/W2919428694","https://openalex.org/W4296270000","https://openalex.org/W3103815445","https://openalex.org/W2411653697","https://openalex.org/W2119108207","https://openalex.org/W1458434589","https://openalex.org/W2601331691"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1],"ability":[2],"of":[3,45,52,61,104,110,131,145],"cells":[4],"to":[5,39,55,70,123,138,183],"complete":[6],"mitosis":[7],"with":[8,29],"high":[9],"fidelity":[10],"relies":[11,177],"on":[12,100,126,178],"elaborate":[13],"checkpoint":[14,21,56,127,154],"mechanisms.":[15],"We":[16,37,65],"study":[17],"S-":[18],"and":[19,80,94,129,190],"M-phase":[20],"responses":[22],"in":[23,25,58,141,171],"silico":[24],"the":[26,35,50,59,89,101,105,111,132,139,142,146,172],"budding":[27],"yeast":[28,112,173],"a":[30,156],"stochastic":[31,72,165],"dynamical":[32,73,169],"model":[33,114],"for":[34,75,153],"cell-cycle.":[36],"aim":[38],"provide":[40],"an":[41,67,76],"unbiased":[42],"functional":[43],"classification":[44],"network":[46,79,175,191],"interactions":[47],"that":[48,158],"reflect":[49],"contribution":[51],"each":[53,120],"link":[54,121],"efficiency":[57],"presence":[60],"cellular":[62],"fluctuations.":[63],"RESULTS:":[64],"developed":[66],"algorithm":[68],"BNetDyn":[69],"compute":[71],"trajectories":[74],"input":[77],"gene":[78],"its":[81,124],"structural":[82],"perturbations.":[83],"User":[84],"specified":[85],"output":[86,95],"measures":[87],"like":[88],"mutual":[90],"information":[91],"between":[92],"trigger":[93],"nodes":[96],"are":[97],"then":[98],"evaluated":[99],"stationary":[102],"state":[103],"Markov":[106],"process.":[107],"Systematic":[108],"perturbations":[109],"cell-cycle":[113,134,174],"by":[115],"Li":[116],"et":[117],"al.":[118],"classify":[119],"according":[122],"effect":[125],"efficiencies":[128],"stabilities":[130],"main":[133],"phases.":[135],"This":[136],"points":[137],"crosstalk":[140],"cascades":[143],"downstream":[144],"SBF/MBF":[147],"transcription":[148],"activator":[149],"complexes":[150],"as":[151],"determinant":[152],"optimality;":[155],"finding":[157],"consistently":[159],"reflects":[160],"recent":[161],"experiments.":[162],"Finally":[163],"our":[164],"analysis":[166],"emphasizes":[167],"how":[168],"stability":[170],"crucially":[176],"backward":[179],"inhibitory":[180],"circuits":[181],"next":[182],"forward":[184],"induction.":[185],"AVAILABILITY:":[186],"C++":[187],"source":[188],"code":[189],"models":[192],"can":[193],"be":[194],"downloaded":[195],"at":[196],"http://www.vital-it.ch/Software/":[197]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
