{"id":"https://openalex.org/W2109044536","doi":"https://doi.org/10.1093/bioinformatics/btl424","title":"Group testing for pathway analysis improves comparability of different microarray datasets","display_name":"Group testing for pathway analysis improves comparability of different microarray datasets","publication_year":2006,"publication_date":"2006-08-07","ids":{"openalex":"https://openalex.org/W2109044536","doi":"https://doi.org/10.1093/bioinformatics/btl424","mag":"2109044536","pmid":"https://pubmed.ncbi.nlm.nih.gov/16895928"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl424","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl424","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2500/48841778/bioinformatics_22_20_2500.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2500/48841778/bioinformatics_22_20_2500.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028361441","display_name":"Theodora Manoli","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theodora Manoli","raw_affiliation_strings":["Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany","Medical Research Center, University Hospital Mannheim 2 \u00a0 2 \u00a0 \u00a0 68167 Mannheim, Germany","Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Medical Research Center, University Hospital Mannheim 2 \u00a0 2 \u00a0 \u00a0 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109137840","display_name":"Norbert Gretz","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Gretz","raw_affiliation_strings":["Medical Research Center, University Hospital Mannheim 2 \u00a0 2 \u00a0 \u00a0 68167 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, University Hospital Mannheim 2 \u00a0 2 \u00a0 \u00a0 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110897701","display_name":"Hermann\u2010Josef Gr\u00f6ne","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermann-Josef Gr\u00f6ne","raw_affiliation_strings":["Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062859201","display_name":"Marc Kenzelmann","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Kenzelmann","raw_affiliation_strings":["Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pathology, German Cancer Research Center 3 \u00a0 3 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044191947","display_name":"Roland Eils","orcid":"https://orcid.org/0000-0002-0034-4036"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Eils","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057450854","display_name":"Benedikt Brors","orcid":"https://orcid.org/0000-0001-5940-3101"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benedikt Brors","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Reseach Center 1 \u00a0 1 \u00a0 \u00a0 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5057450854"],"corresponding_institution_ids":["https://openalex.org/I17937529"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":7.6364,"has_fulltext":true,"cited_by_count":152,"citation_normalized_percentile":{"value":0.9814682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"22","issue":"20","first_page":"2500","last_page":"2506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.7972004413604736},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6608679890632629},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.5451759696006775},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.5088891983032227},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.5050957798957825},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4970259964466095},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.49469849467277527},{"id":"https://openalex.org/keywords/exact-test","display_name":"Exact test","score":0.4926820397377014},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.453410267829895},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4281955659389496},{"id":"https://openalex.org/keywords/microarray-databases","display_name":"Microarray databases","score":0.4267186224460602},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4186651110649109},{"id":"https://openalex.org/keywords/database-normalization","display_name":"Database normalization","score":0.4163101315498352},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.4149683117866516},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41402724385261536},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.4104980230331421},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36061087250709534},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3153325319290161},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25710880756378174},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22199785709381104},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20364689826965332},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.18963199853897095},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.173289954662323},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13186797499656677},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12408238649368286},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.11542913317680359}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.7972004413604736},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6608679890632629},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.5451759696006775},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.5088891983032227},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.5050957798957825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4970259964466095},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.49469849467277527},{"id":"https://openalex.org/C191093355","wikidata":"https://www.wikidata.org/wiki/Q9250577","display_name":"Exact test","level":2,"score":0.4926820397377014},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.453410267829895},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4281955659389496},{"id":"https://openalex.org/C548314002","wikidata":"https://www.wikidata.org/wiki/Q6839218","display_name":"Microarray databases","level":5,"score":0.4267186224460602},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4186651110649109},{"id":"https://openalex.org/C162984825","wikidata":"https://www.wikidata.org/wiki/Q339072","display_name":"Database normalization","level":3,"score":0.4163101315498352},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.4149683117866516},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41402724385261536},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.4104980230331421},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36061087250709534},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3153325319290161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25710880756378174},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22199785709381104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20364689826965332},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.18963199853897095},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.173289954662323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13186797499656677},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12408238649368286},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.11542913317680359},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl424","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl424","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2500/48841778/bioinformatics_22_20_2500.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16895928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16895928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btl424","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl424","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/20/2500/48841778/bioinformatics_22_20_2500.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109044536.pdf","grobid_xml":"https://content.openalex.org/works/W2109044536.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1535641839","https://openalex.org/W1571917377","https://openalex.org/W1601826601","https://openalex.org/W1964895626","https://openalex.org/W1969761972","https://openalex.org/W1977422169","https://openalex.org/W1983259239","https://openalex.org/W1985695385","https://openalex.org/W1992443647","https://openalex.org/W2002156802","https://openalex.org/W2003469582","https://openalex.org/W2014620140","https://openalex.org/W2020943639","https://openalex.org/W2021129827","https://openalex.org/W2026543586","https://openalex.org/W2049849487","https://openalex.org/W2109363337","https://openalex.org/W2110065044","https://openalex.org/W2111476798","https://openalex.org/W2115632577","https://openalex.org/W2118069309","https://openalex.org/W2122598723","https://openalex.org/W2123106337","https://openalex.org/W2128985829","https://openalex.org/W2130410032","https://openalex.org/W2135230352","https://openalex.org/W2150414518","https://openalex.org/W2157132621","https://openalex.org/W2157795344","https://openalex.org/W2159400887","https://openalex.org/W2160697532","https://openalex.org/W2319794630","https://openalex.org/W2582743722","https://openalex.org/W4229880569","https://openalex.org/W4294107304","https://openalex.org/W6634013245"],"related_works":["https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W2093104131","https://openalex.org/W4300887971","https://openalex.org/W2178204436","https://openalex.org/W2143079975","https://openalex.org/W2026085942","https://openalex.org/W2333750400","https://openalex.org/W1986765826","https://openalex.org/W2076024021"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1],"wide":[2],"use":[3],"of":[4,10,17,23,32,47,70,76,136,202,208,297],"DNA":[5],"microarrays":[6,137],"for":[7,20],"the":[8,11,15,21,37,45,68,109,141,149,158,165,174,194,214,220,243,262,277,295],"investigation":[9],"cell":[12],"transcriptome":[13],"triggered":[14],"invention":[16],"numerous":[18],"methods":[19,54,191,217,272,283],"processing":[22],"microarray":[24,33,111],"data":[25,143,150],"and":[26,144,164,185,200,237,273],"lead":[27],"to":[28,120,140,148,169,178,193,219,226,242,261,291,310],"a":[29,316,320],"growing":[30],"number":[31,207],"studies":[34],"that":[35,286],"examine":[36],"same":[38,110,175,195],"biological":[39],"conditions.":[40],"However,":[41,279],"comparisons":[42],"made":[43],"on":[44,67,266,319],"level":[46,69],"gene":[48,210,267],"lists":[49,172,188,211,268],"obtained":[50,107,212,269],"by":[51,87,122,152,213,229,235,252,270],"different":[52,57,179,190,271,274],"statistical":[53,134,216],"or":[55,80,98,128],"from":[56,173,189,315],"datasets":[58,106,180,222,275],"hardly":[59],"converge.":[60],"We":[61],"aimed":[62],"at":[63],"examining":[64],"such":[65],"discrepancies":[66],"apparently":[71],"affected":[72],"biologically":[73],"related":[74],"groups":[75],"genes,":[77],"e.g.":[78,91],"metabolic":[79],"signalling":[81],"pathways.":[82],"This":[83],"can":[84],"be":[85,292,311],"achieved":[86],"group":[88,227,281],"testing":[89,156,228,234,282],"procedures,":[90],"over-representation":[92],"analysis,":[93],"functional":[94],"class":[95],"scoring":[96],"(FCS),":[97],"global":[99,238,253],"tests.":[100],"RESULTS:":[101],"Three":[102],"public":[103],"prostate":[104,298],"cancer":[105],"with":[108,259],"platform":[112],"(HGU95A/HGU95Av2)":[113],"were":[114],"analyzed.":[115],"Each":[116],"dataset":[117,196],"was":[118,138,162,167,223,240],"subjected":[119,225],"normalization":[121,126,131],"either":[123],"variance":[124],"stabilizing":[125],"(vsn)":[127],"mixed":[129,145],"model":[130,146],"(MMN).":[132],"Then,":[133],"analysis":[135,147,318],"applied":[139,177,192,218,241],"vsn-normalized":[142],"normalized":[151],"MMN.":[153],"For":[154],"multiple":[155],"adjustment":[157],"false":[159],"discovery":[160],"rate":[161],"calculated":[163],"threshold":[166],"set":[168],"0.05.":[170],"Gene":[171],"method":[176],"showed":[181,255],"overlaps":[182],"between":[183,198,264],"42":[184],"52%,":[186],"while":[187],"had":[197,287],"63":[199],"85%":[201],"genes":[203],"in":[204,294,304],"common.":[205],"A":[206],"six":[209],"two":[215],"three":[221,244],"then":[224],"Fisher's":[230,248],"exact":[231,249],"test.":[232],"Group":[233],"GSEA":[236],"test":[239,250,254],"datasets,":[245],"as":[246],"well.":[247],"followed":[251],"more":[256,308],"consistent":[257],"results":[258],"respect":[260],"concordance":[263],"analyses":[265,306],"than":[276,313],"GSEA.":[278],"all":[280],"identified":[284,303],"pathways":[285,301],"already":[288],"been":[289],"described":[290],"involved":[293],"pathogenesis":[296],"cancer.":[299],"Moreover,":[300],"recurrently":[302],"these":[305],"are":[307],"likely":[309],"reliable":[312],"those":[314],"single":[317,321],"dataset.":[322]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}