{"id":"https://openalex.org/W2163296862","doi":"https://doi.org/10.1093/bioinformatics/btl396","title":"Inferring gene regulatory networks from multiple microarray datasets","display_name":"Inferring gene regulatory networks from multiple microarray datasets","publication_year":2006,"publication_date":"2006-07-24","ids":{"openalex":"https://openalex.org/W2163296862","doi":"https://doi.org/10.1093/bioinformatics/btl396","mag":"2163296862","pmid":"https://pubmed.ncbi.nlm.nih.gov/16864593"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl396","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl396","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100604633","display_name":"Yong Wang","orcid":"https://orcid.org/0000-0003-0989-9764"},"institutions":[{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]},{"id":"https://openalex.org/I4210120485","display_name":"Academy of Mathematics and Systems Science","ror":"https://ror.org/02jkmyk67","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210120485"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Yong Wang","raw_affiliation_strings":["Academy of Mathematics and Systems Science, CAS 2 \u00a0 2 \u00a0 \u00a0 Beijing 100080, China","Department of Electrical Engineering and Electronics, Osaka Sangyo University 1 \u00a0 1 \u00a0 \u00a0 Osaka 574-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Mathematics and Systems Science, CAS 2 \u00a0 2 \u00a0 \u00a0 Beijing 100080, China","institution_ids":["https://openalex.org/I4210120485"]},{"raw_affiliation_string":"Department of Electrical Engineering and Electronics, Osaka Sangyo University 1 \u00a0 1 \u00a0 \u00a0 Osaka 574-8530, Japan","institution_ids":["https://openalex.org/I133712593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071079252","display_name":"Trupti Joshi","orcid":"https://orcid.org/0000-0001-8944-4924"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trupti Joshi","raw_affiliation_strings":["Computer Science Department and Christopher S. Bond Life Sciences Center, University of Missouri 3 \u00a0 3 \u00a0 \u00a0 Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Department and Christopher S. Bond Life Sciences Center, University of Missouri 3 \u00a0 3 \u00a0 \u00a0 Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108198322","display_name":"Xiang\u2010Sun Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120485","display_name":"Academy of Mathematics and Systems Science","ror":"https://ror.org/02jkmyk67","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210120485"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Sun Zhang","raw_affiliation_strings":["Academy of Mathematics and Systems Science, CAS 2 \u00a0 2 \u00a0 \u00a0 Beijing 100080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Mathematics and Systems Science, CAS 2 \u00a0 2 \u00a0 \u00a0 Beijing 100080, China","institution_ids":["https://openalex.org/I4210120485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082428303","display_name":"Dong Xu","orcid":"https://orcid.org/0000-0002-4809-0514"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Xu","raw_affiliation_strings":["Computer Science Department and Christopher S. Bond Life Sciences Center, University of Missouri 3 \u00a0 3 \u00a0 \u00a0 Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Department and Christopher S. Bond Life Sciences Center, University of Missouri 3 \u00a0 3 \u00a0 \u00a0 Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["Department of Electrical Engineering and Electronics, Osaka Sangyo University 1 \u00a0 1 \u00a0 \u00a0 Osaka 574-8530, Japan","Institute of Systems Biology, Shanghai University 4 \u00a0 4 \u00a0 \u00a0 Shanghai 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Electronics, Osaka Sangyo University 1 \u00a0 1 \u00a0 \u00a0 Osaka 574-8530, Japan","institution_ids":["https://openalex.org/I133712593"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University 4 \u00a0 4 \u00a0 \u00a0 Shanghai 200444, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":9.4547,"has_fulltext":false,"cited_by_count":331,"citation_normalized_percentile":{"value":0.98804196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"22","issue":"19","first_page":"2413","last_page":"2420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6813264489173889},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6656436324119568},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6370012760162354},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5773934125900269},{"id":"https://openalex.org/keywords/arabidopsis","display_name":"Arabidopsis","score":0.5721182227134705},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.482862263917923},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.4660341143608093},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4365188181400299},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35167866945266724},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.321233332157135},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28775882720947266},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20118394494056702},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17684128880500793},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13971251249313354}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6813264489173889},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6656436324119568},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6370012760162354},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5773934125900269},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5721182227134705},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.482862263917923},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.4660341143608093},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4365188181400299},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35167866945266724},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.321233332157135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28775882720947266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20118394494056702},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17684128880500793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13971251249313354},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl396","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl396","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16864593","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16864593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332483","display_name":"Cooperative State Research, Education, and Extension Service","ror":"https://ror.org/01na82s61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1972764318","https://openalex.org/W1992242907","https://openalex.org/W2007471837","https://openalex.org/W2008107402","https://openalex.org/W2012804055","https://openalex.org/W2018435536","https://openalex.org/W2058221907","https://openalex.org/W2066438284","https://openalex.org/W2073899230","https://openalex.org/W2074993687","https://openalex.org/W2077177797","https://openalex.org/W2095622082","https://openalex.org/W2100408255","https://openalex.org/W2106202847","https://openalex.org/W2113654344","https://openalex.org/W2114382052","https://openalex.org/W2120027714","https://openalex.org/W2128506325","https://openalex.org/W2134092975","https://openalex.org/W2141314326","https://openalex.org/W2142610549","https://openalex.org/W2145644212","https://openalex.org/W2146264532","https://openalex.org/W2146506956","https://openalex.org/W2148944713","https://openalex.org/W2153208554","https://openalex.org/W2156276695","https://openalex.org/W2159342324","https://openalex.org/W2161409973","https://openalex.org/W2163296727","https://openalex.org/W2166106382","https://openalex.org/W2169690805","https://openalex.org/W4248863483","https://openalex.org/W6668802804","https://openalex.org/W6680722016"],"related_works":["https://openalex.org/W1986892844","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W170658859","https://openalex.org/W2490137852","https://openalex.org/W3141198878","https://openalex.org/W2056932428","https://openalex.org/W1982897783","https://openalex.org/W2034613288","https://openalex.org/W1483316219"],"abstract_inverted_index":{"MOTIVATION:":[0],"Microarray":[1],"gene":[2,54,64,116,201],"expression":[3,65],"data":[4,10,66,166,181,184],"has":[5,91],"increasingly":[6,73],"become":[7],"the":[8,25,50,61,143,146,156,163,172,192,222],"common":[9],"source":[11],"that":[12,31],"can":[13,79],"provide":[14],"insights":[15],"into":[16],"biological":[17],"processes":[18],"at":[19],"a":[20,32,43,93,102,136],"system-wide":[21],"level.":[22],"One":[23],"of":[24,35,46,52,96,145,155,165,194,198],"major":[26],"problems":[27],"with":[28,40,151],"microarrays":[29],"is":[30,122,130,211],"dataset":[33],"consists":[34],"relatively":[36],"few":[37],"time":[38],"points":[39],"respect":[41,152],"to":[42,105,153],"large":[44],"number":[45,95],"genes,":[47],"which":[48,129],"makes":[49],"problem":[51,164],"inferring":[53,115],"regulatory":[55,117,202],"network":[56,149],"an":[57],"ill-posed":[58],"one.":[59],"On":[60],"other":[62],"hand,":[63],"generated":[67],"by":[68],"different":[69,112],"groups":[70],"worldwide":[71],"are":[72],"accumulated":[74],"on":[75,132],"many":[76],"species":[77],"and":[78,135,182,187,206,216],"be":[80],"accessed":[81],"from":[82,111,213,221],"public":[83],"databases":[84],"or":[85,218],"individual":[86],"websites,":[87],"although":[88],"each":[89],"experiment":[90],"only":[92,160],"limited":[94],"time-points.":[97],"RESULTS:":[98],"This":[99],"paper":[100],"proposes":[101],"novel":[103],"method":[104,121,140],"combine":[106],"multiple":[107],"time-course":[108],"microarray":[109],"datasets":[110],"conditions":[113],"for":[114],"networks.":[118],"The":[119,139,189,209],"proposed":[120],"called":[123],"GNR":[124,177,195],"(Gene":[125],"Network":[126],"Reconstruction":[127],"tool)":[128],"based":[131],"linear":[133],"programming":[134],"decomposition":[137],"procedure.":[138],"theoretically":[141],"ensures":[142],"derivation":[144],"most":[147],"consistent":[148],"structure":[150],"all":[154],"datasets,":[157],"thereby":[158],"not":[159],"significantly":[161],"alleviating":[162],"scarcity":[167],"but":[168],"also":[169],"remarkably":[170],"improving":[171],"prediction":[173],"reliability.":[174],"We":[175],"tested":[176],"using":[178],"both":[179],"simulated":[180],"experimental":[183],"in":[185,196,204],"yeast":[186,205],"Arabidopsis.":[188,207],"result":[190],"demonstrates":[191],"effectiveness":[193],"terms":[197],"predicting":[199],"new":[200],"relationship":[203],"AVAILABILITY:":[208],"software":[210],"available":[212],"http://zhangorup.aporc.org/bioinfo/grninfer/,":[214],"http://digbio.missouri.edu/grninfer/":[215],"http://intelligent.eic.osaka-sandai.ac.jp":[217],"upon":[219],"request":[220],"authors.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":35}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}