{"id":"https://openalex.org/W2111825982","doi":"https://doi.org/10.1093/bioinformatics/btl181","title":"Observing local and global properties of metabolic pathways: \u2018load points\u2019 and \u2018choke points\u2019 in the metabolic networks","display_name":"Observing local and global properties of metabolic pathways: \u2018load points\u2019 and \u2018choke points\u2019 in the metabolic networks","publication_year":2006,"publication_date":"2006-05-08","ids":{"openalex":"https://openalex.org/W2111825982","doi":"https://doi.org/10.1093/bioinformatics/btl181","mag":"2111825982","pmid":"https://pubmed.ncbi.nlm.nih.gov/16682421"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl181","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl181","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1767/48839029/bioinformatics_22_14_1767.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1767/48839029/bioinformatics_22_14_1767.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012394374","display_name":"Syed Asad Rahman","orcid":"https://orcid.org/0000-0002-7602-6675"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Syed Asad Rahman","raw_affiliation_strings":["Cologne University Bioinformatics Center, CUBIC 1 \u00a0 1 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cologne University Bioinformatics Center, CUBIC 1 \u00a0 1 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043042218","display_name":"Dietmar Schomburg","orcid":"https://orcid.org/0000-0002-3354-822X"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dietmar Schomburg","raw_affiliation_strings":["Cologne University Bioinformatics Center, CUBIC 1 \u00a0 1 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany","Institute for Biochemistry 2 \u00a0 2 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cologne University Bioinformatics Center, CUBIC 1 \u00a0 1 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute for Biochemistry 2 \u00a0 2 \u00a0 \u00a0 Z\u00fclpicher Strasse 47, 50674 Koeln, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043042218"],"corresponding_institution_ids":["https://openalex.org/I180923762"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.3639,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.95000207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"14","first_page":"1767","last_page":"1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1031000018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0625,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.8864990472793579},{"id":"https://openalex.org/keywords/bacillus-anthracis","display_name":"Bacillus anthracis","score":0.7552493810653687},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6737461686134338},{"id":"https://openalex.org/keywords/choke","display_name":"Choke","score":0.6620429754257202},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.6544665098190308},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5719363689422607},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5109823942184448},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.4871618449687958},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44868481159210205},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.438502699136734},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3901088833808899},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3068512976169586},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.29103994369506836},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20053806900978088},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18002715706825256},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11106234788894653}],"concepts":[{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.8864990472793579},{"id":"https://openalex.org/C2780239966","wikidata":"https://www.wikidata.org/wiki/Q614156","display_name":"Bacillus anthracis","level":3,"score":0.7552493810653687},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6737461686134338},{"id":"https://openalex.org/C29049376","wikidata":"https://www.wikidata.org/wiki/Q864746","display_name":"Choke","level":2,"score":0.6620429754257202},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6544665098190308},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5719363689422607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5109823942184448},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.4871618449687958},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44868481159210205},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.438502699136734},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3901088833808899},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3068512976169586},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29103994369506836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20053806900978088},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18002715706825256},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11106234788894653},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btl181","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl181","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1767/48839029/bioinformatics_22_14_1767.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16682421","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16682421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.408.2873","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.408.2873","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://kiwi.cs.dal.ca/~beiko/wp-content/uploads/rahman2006-binf.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btl181","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl181","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1767/48839029/bioinformatics_22_14_1767.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46000000834465027}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111825982.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1549912426","https://openalex.org/W1551787983","https://openalex.org/W1584846756","https://openalex.org/W1644749979","https://openalex.org/W1758395617","https://openalex.org/W1966902043","https://openalex.org/W1968286256","https://openalex.org/W1970599841","https://openalex.org/W1971421925","https://openalex.org/W1976672440","https://openalex.org/W1977510886","https://openalex.org/W1979537657","https://openalex.org/W1982309495","https://openalex.org/W1994656497","https://openalex.org/W2017987256","https://openalex.org/W2018045523","https://openalex.org/W2032074709","https://openalex.org/W2047649079","https://openalex.org/W2064483836","https://openalex.org/W2070672503","https://openalex.org/W2078807391","https://openalex.org/W2091879895","https://openalex.org/W2094097101","https://openalex.org/W2094491295","https://openalex.org/W2096484674","https://openalex.org/W2100882223","https://openalex.org/W2101289679","https://openalex.org/W2101551644","https://openalex.org/W2106808145","https://openalex.org/W2108859156","https://openalex.org/W2113221321","https://openalex.org/W2133319394","https://openalex.org/W2142237411","https://openalex.org/W2144000913","https://openalex.org/W2144885342","https://openalex.org/W2148797284","https://openalex.org/W2151390110","https://openalex.org/W2152776677","https://openalex.org/W2156650715","https://openalex.org/W2158714788","https://openalex.org/W2163480486","https://openalex.org/W2398071790","https://openalex.org/W2469904498","https://openalex.org/W2944782266","https://openalex.org/W3103786587","https://openalex.org/W4211085285","https://openalex.org/W4294326454","https://openalex.org/W4298203020","https://openalex.org/W6682550734"],"related_works":["https://openalex.org/W1969539025","https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W1961707331","https://openalex.org/W2012938657","https://openalex.org/W2096004952","https://openalex.org/W1578136679","https://openalex.org/W2087715585","https://openalex.org/W2147962989","https://openalex.org/W4309835295"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,133,228,297],"local":[2],"and":[3,52,58,105,113,120,177,206,272,299],"global":[4],"aspects":[5],"of":[6,23,32,75,80,97,110,127,144,169,174,239,251,314],"metabolic":[7,50,64,81,131,170,275],"network":[8,51,238,276],"analyses":[9],"allow":[10],"us":[11,28],"to":[12,44,56,88,122,159,182],"identify":[13,160],"enzymes":[14,184],"or":[15,189],"reactions":[16],"that":[17,140],"are":[18,245,303],"crucial":[19],"for":[20],"the":[21,24,30,46,49,60,76,90,108,125,130,138,141,154,166,172,220,235,249,252,258,265,273,293,306,311],"survival":[22],"organism(s),":[25],"therefore":[26],"directing":[27],"towards":[29],"discovery":[31],"potential":[33,161],"drug":[34,162,243],"targets.":[35],"RESULTS:":[36],"We":[37],"demonstrate":[38],"a":[39,54,145,191,207,289],"new":[40],"method":[41],"('load":[42],"points')":[43],"rank":[45,59,124],"enzymes/metabolites":[47],"in":[48,63,129,153,257,305],"propose":[53],"model":[55,79,226],"determine":[57],"biochemical":[61,142,167],"lethality":[62,168],"networks":[65],"(enzymes/metabolites)":[66],"through":[67],"'choke":[68],"points'.":[69],"Based":[70],"on":[71,165,234,248,284,318],"an":[72],"extended":[73],"form":[74],"graph":[77],"theory":[78],"networks,":[82],"metabolite":[83,193],"structural":[84],"information":[85],"was":[86,180,232,277],"used":[87,121,181],"calculate":[89],"k-shortest":[91],"paths":[92,112],"between":[93,103,264],"metabolites":[94],"(the":[95],"presence":[96],"more":[98],"than":[99,148],"one":[100],"competing":[101],"path":[102],"substrate":[104],"product).":[106],"On":[107],"basis":[109],"these":[111],"connectivity":[114,150],"information,":[115],"load":[116,134,178,298],"points":[117,176,179,256,271],"were":[118,223,282],"calculated":[119],"empirically":[123],"importance":[126],"metabolites/enzymes":[128],"network.":[132,260],"point":[135,230,301],"analysis":[136,250],"emphasizes":[137],"role":[139],"structure":[143],"metabolite,":[146],"rather":[147],"its":[149],"(hubs),":[151],"plays":[152],"conversion":[155],"pathway.":[156],"In":[157],"order":[158],"targets":[163,244],"(based":[164],"networks),":[171],"concept":[173],"choke":[175,229,255,270,300],"find":[183],"(edges)":[185],"which":[186,315],"uniquely":[187],"consume":[188],"produce":[190],"particular":[192],"(nodes).":[194],"A":[195,261],"non-pathogenic":[196],"bacterial":[197,210,237,259,269],"strain":[198,211],"Bacillus":[199,212],"subtilis":[200],"168":[201],"(lactic":[202],"acid":[203],"producing":[204,219],"bacteria)":[205],"related":[208],"pathogenic":[209],"anthracis":[213],"Sterne":[214],"(avirulent":[215],"but":[216],"toxigenic":[217],"strain,":[218],"toxin":[221],"Anthrax)":[222],"selected":[224],"as":[225],"organisms.":[227],"strategy":[231],"implemented":[233],"pathogen":[236],"B.anthracis":[240],"Sterne.":[241],"Potential":[242],"proposed":[246],"based":[247],"top":[253,267],"10":[254,268],"comparative":[262],"study":[263],"reported":[266],"human":[274,294],"performed.":[278],"Further":[279],"biological":[280],"inferences":[281],"made":[283],"results":[285],"obtained":[286],"by":[287],"performing":[288],"homology":[290],"search":[291],"against":[292],"genome.":[295],"AVAILABILITY:":[296],"modules":[302],"introduced":[304],"Pathway":[307],"Hunter":[308],"Tool":[309],"(PHT),":[310],"basic":[312],"version":[313],"is":[316],"available":[317],"http://www.pht.uni-koeln.de.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
