{"id":"https://openalex.org/W2143508593","doi":"https://doi.org/10.1093/bioinformatics/btl165","title":"A Mixture model with random-effects components for clustering correlated gene-expression profiles","display_name":"A Mixture model with random-effects components for clustering correlated gene-expression profiles","publication_year":2006,"publication_date":"2006-05-03","ids":{"openalex":"https://openalex.org/W2143508593","doi":"https://doi.org/10.1093/bioinformatics/btl165","mag":"2143508593","pmid":"https://pubmed.ncbi.nlm.nih.gov/16675467"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl165","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1745/611126/btl165.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1745/611126/btl165.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057826032","display_name":"Shu\u2010Kay Ng","orcid":"https://orcid.org/0000-0002-6865-9384"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"S. K. Ng","raw_affiliation_strings":["Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology 4 \u00a0 4 \u00a0 \u00a0 Brigham and Women's Hospital, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology 4 \u00a0 4 \u00a0 \u00a0 Brigham and Women's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057375178","display_name":"Geoffrey J. McLachlan","orcid":"https://orcid.org/0000-0002-5921-3145"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"G. J. McLachlan","raw_affiliation_strings":["ARC Centre for Complex Systems, University of Queensland 3 \u00a0 3 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","Institute for Molecular Bioscience, University of Queensland 2 \u00a0 2 \u00a0 \u00a0 Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Centre for Complex Systems, University of Queensland 3 \u00a0 3 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland 2 \u00a0 2 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078190532","display_name":"Kean Wang","orcid":"https://orcid.org/0000-0003-1111-1155"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"K. Wang","raw_affiliation_strings":["ARC Centre for Complex Systems, University of Queensland 3 \u00a0 3 \u00a0 \u00a0 Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Centre for Complex Systems, University of Queensland 3 \u00a0 3 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042931090","display_name":"L. Ben-Tovim Jones","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"L. Ben-Tovim Jones","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland 2 \u00a0 2 \u00a0 \u00a0 Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland 2 \u00a0 2 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103433764","display_name":"S.-W. Ng","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"S.-W. Ng","raw_affiliation_strings":["Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology 4 \u00a0 4 \u00a0 \u00a0 Brigham and Women's Hospital, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Queensland 1 \u00a0 1 \u00a0 \u00a0 Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology 4 \u00a0 4 \u00a0 \u00a0 Brigham and Women's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057375178"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.447,"has_fulltext":true,"cited_by_count":155,"citation_normalized_percentile":{"value":0.95396589,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"22","issue":"14","first_page":"1745","last_page":"1752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9394000172615051,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9394000172615051,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7107630372047424},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5076102018356323},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.50518399477005},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45838019251823425},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4574018120765686},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4458523392677307},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.35270869731903076},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34525465965270996},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.32289013266563416},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3205329477787018},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26665183901786804},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08265212178230286}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7107630372047424},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5076102018356323},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.50518399477005},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45838019251823425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4574018120765686},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4458523392677307},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.35270869731903076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34525465965270996},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32289013266563416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3205329477787018},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26665183901786804},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08265212178230286}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btl165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl165","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1745/611126/btl165.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16675467","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16675467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:708557","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/20784","is_oa":false,"landing_page_url":"http://hdl.handle.net/10072/20784","pdf_url":null,"source":{"id":"https://openalex.org/S4306402548","display_name":"Griffith Research Online (Griffith University, Queensland, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11701301","host_organization_name":"Griffith University","host_organization_lineage":["https://openalex.org/I11701301"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btl165","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl165","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/14/1745/611126/btl165.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143508593.pdf","grobid_xml":"https://content.openalex.org/works/W2143508593.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1528177290","https://openalex.org/W1557752234","https://openalex.org/W1558792315","https://openalex.org/W1565240145","https://openalex.org/W1572134371","https://openalex.org/W1579271636","https://openalex.org/W1840933474","https://openalex.org/W1907059778","https://openalex.org/W1976169036","https://openalex.org/W1992402718","https://openalex.org/W1995945562","https://openalex.org/W1999755876","https://openalex.org/W2001277212","https://openalex.org/W2030769837","https://openalex.org/W2047555270","https://openalex.org/W2049633694","https://openalex.org/W2055867223","https://openalex.org/W2065912508","https://openalex.org/W2091541663","https://openalex.org/W2100128674","https://openalex.org/W2103017472","https://openalex.org/W2103453943","https://openalex.org/W2110598359","https://openalex.org/W2118727666","https://openalex.org/W2120413242","https://openalex.org/W2124482801","https://openalex.org/W2129476886","https://openalex.org/W2136097953","https://openalex.org/W2141951767","https://openalex.org/W2146646206","https://openalex.org/W2149566602","https://openalex.org/W2150473224","https://openalex.org/W2151566419","https://openalex.org/W2152012752","https://openalex.org/W2159578516","https://openalex.org/W2164628006","https://openalex.org/W2165086994","https://openalex.org/W2168175751","https://openalex.org/W2168846334","https://openalex.org/W2170040895","https://openalex.org/W2172085063","https://openalex.org/W2488678869","https://openalex.org/W2490800645","https://openalex.org/W2492794003","https://openalex.org/W2495373072","https://openalex.org/W2507058334","https://openalex.org/W2611831635","https://openalex.org/W2802533528","https://openalex.org/W2993708662","https://openalex.org/W3106889297","https://openalex.org/W4235169531","https://openalex.org/W6633267158","https://openalex.org/W6644027154"],"related_works":["https://openalex.org/W2804364458","https://openalex.org/W4298130764","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W2393816671","https://openalex.org/W2158836806","https://openalex.org/W2083665254","https://openalex.org/W1926736923","https://openalex.org/W2942177010"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,241],"clustering":[2,34,115,159,249],"of":[3,10,17,23,29,42,75,84,98,116,127,135,243,250,276],"gene":[4,19,24,70,147,252],"profiles":[5,41,71,148,253],"across":[6],"some":[7],"experimental":[8,60,128,195,263],"conditions":[9],"interest":[11],"contributes":[12],"significantly":[13],"to":[14,113,140,150,154,166,184,191],"the":[15,21,27,40,43,51,66,69,73,76,87,92,95,114,136,143,146,158,162,193,211,216,234,248,277,312],"elucidation":[16],"unknown":[18],"function,":[20],"validation":[22],"discoveries":[25],"and":[26,50,72,149,183,268],"interpretation":[28],"biological":[30],"processes.":[31],"However,":[32],"this":[33],"problem":[35],"is":[36,132,164,254,291,307],"not":[37,46],"straightforward":[38],"as":[39,180],"genes":[44,117,278],"are":[45,279,282],"all":[47],"independently":[48],"distributed":[49],"expression":[52,120],"levels":[53,121],"may":[54],"have":[55],"been":[56],"obtained":[57],"from":[58,311],"an":[59,133],"design":[61],"involving":[62],"replicated":[63,77],"arrays.":[64],"Ignoring":[65],"dependence":[67],"between":[68,145],"structure":[74],"data":[78],"can":[79,204,220,229],"result":[80],"in":[81,86,91,123,223],"important":[82],"sources":[83],"variability":[85],"experiments":[88,176,186],"being":[89,101],"overlooked":[90],"analysis,":[93],"with":[94,118,169],"consequent":[96],"possibility":[97],"misleading":[99],"inferences":[100],"made.":[102],"We":[103,198],"propose":[104],"a":[105,110,124,181],"random-effects":[106,202],"model":[107,131,139,163,203,228],"that":[108,200],"provides":[109],"unified":[111],"approach":[112],"correlated":[119,251],"measured":[122],"wide":[125],"variety":[126],"situations.":[129],"Our":[130],"extension":[134],"normal":[137],"mixture":[138],"account":[141],"for":[142,173,214,236,247],"correlations":[144],"enable":[151],"covariate":[152],"information":[153],"be":[155,205,221,230],"incorporated":[156],"into":[157],"process.":[160],"Hence":[161,226],"applicable":[165],"longitudinal":[167],"studies":[168],"or":[170],"without":[171,233],"replication,":[172],"example,":[174],"time-course":[175],"by":[177,187,207,284],"using":[178,188],"time":[179],"covariate,":[182],"cross-sectional":[185,269],"categorical":[189],"covariates":[190],"represent":[192],"different":[194],"classes.":[196],"RESULTS:":[197],"show":[199],"our":[201,227,244],"fitted":[206,231],"maximum":[208],"likelihood":[209],"via":[210],"EM":[212],"algorithm":[213],"which":[215,281],"E(expectation)and":[217],"M(maximization)":[218],"steps":[219],"implemented":[222],"closed":[224],"form.":[225],"deterministically":[232],"need":[235],"time-consuming":[237],"Monte":[238],"Carlo":[239],"approximations.":[240],"effectiveness":[242],"model-based":[245],"procedure":[246],"demonstrated":[255],"on":[256,309],"three":[257],"real":[258],"datasets,":[259],"representing":[260],"typical":[261],"microarray":[262],"designs,":[264],"covering":[265],"time-course,":[266],"repeated-measurement":[267],"data.":[270],"In":[271],"these":[272],"examples,":[273],"relevant":[274],"clusters":[275],"obtained,":[280],"supported":[283],"existing":[285],"gene-function":[286],"annotation.":[287],"A":[288,295],"synthetic":[289],"dataset":[290],"considered":[292],"too.":[293],"AVAILABILITY:":[294],"Fortran":[296],"program":[297],"blue":[298],"called":[299],"EMMIX-WIRE":[300],"(EM-based":[301],"MIXture":[302],"analysis":[303],"WIth":[304],"Random":[305],"Effects)":[306],"available":[308],"request":[310],"corresponding":[313],"author.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":14}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}
