{"id":"https://openalex.org/W2124216517","doi":"https://doi.org/10.1093/bioinformatics/btl075","title":"Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response","display_name":"Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response","publication_year":2006,"publication_date":"2006-03-07","ids":{"openalex":"https://openalex.org/W2124216517","doi":"https://doi.org/10.1093/bioinformatics/btl075","mag":"2124216517","pmid":"https://pubmed.ncbi.nlm.nih.gov/16522671"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/11/1289/48837932/bioinformatics_22_11_1289.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/11/1289/48837932/bioinformatics_22_11_1289.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008418938","display_name":"E. Becker","orcid":"https://orcid.org/0000-0002-7673-0582"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Emmanuelle Becker","raw_affiliation_strings":["Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France","institution_ids":["https://openalex.org/I4210128565","https://openalex.org/I2738703131","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015209574","display_name":"Vincent Meyer","orcid":"https://orcid.org/0000-0001-9144-1618"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Meyer","raw_affiliation_strings":["Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France","institution_ids":["https://openalex.org/I4210128565","https://openalex.org/I2738703131","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009225670","display_name":"Hocine Madaoui","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hocine Madaoui","raw_affiliation_strings":["Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France","institution_ids":["https://openalex.org/I4210128565","https://openalex.org/I2738703131","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043668210","display_name":"Rapha\u00ebl Gu\u00e9rois","orcid":"https://orcid.org/0000-0001-5294-2858"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rapha\u00ebl Guerois","raw_affiliation_strings":["Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biophysique des Fonctions Membranaires, URA CNRS 2096, D\u00e9partement de Biologie Joliot-Curie 1 \u00a0 1 \u00a0 \u00a0 CEA Saclay, 91191 Gif-Sur-Yvette, Cedex, France","institution_ids":["https://openalex.org/I4210128565","https://openalex.org/I2738703131","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008418938"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128565"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":3.9528,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94150558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"22","issue":"11","first_page":"1289","last_page":"1292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nijmegen-breakage-syndrome","display_name":"Nijmegen breakage syndrome","score":0.862031102180481},{"id":"https://openalex.org/keywords/rad50","display_name":"Rad50","score":0.5889639258384705},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5807408094406128},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5641242861747742},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5247012376785278},{"id":"https://openalex.org/keywords/tandem-repeat","display_name":"Tandem repeat","score":0.5242048501968384},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.49306628108024597},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.46096038818359375},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.45294541120529175},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3343907594680786},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.27804118394851685},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.23827555775642395},{"id":"https://openalex.org/keywords/dna-binding-protein","display_name":"DNA-binding protein","score":0.1249762773513794}],"concepts":[{"id":"https://openalex.org/C2777136964","wikidata":"https://www.wikidata.org/wiki/Q1250362","display_name":"Nijmegen breakage syndrome","level":5,"score":0.862031102180481},{"id":"https://openalex.org/C2775984157","wikidata":"https://www.wikidata.org/wiki/Q18035037","display_name":"Rad50","level":5,"score":0.5889639258384705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5807408094406128},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5641242861747742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5247012376785278},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.5242048501968384},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.49306628108024597},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46096038818359375},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.45294541120529175},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3343907594680786},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.27804118394851685},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.23827555775642395},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.1249762773513794},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/11/1289/48837932/bioinformatics_22_11_1289.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16522671","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16522671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btl075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/11/1289/48837932/bioinformatics_22_11_1289.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124216517.pdf","grobid_xml":"https://content.openalex.org/works/W2124216517.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1768635289","https://openalex.org/W1965517743","https://openalex.org/W1969474286","https://openalex.org/W1970984376","https://openalex.org/W1978672439","https://openalex.org/W1983609323","https://openalex.org/W2000752368","https://openalex.org/W2022433764","https://openalex.org/W2024131694","https://openalex.org/W2034195376","https://openalex.org/W2038260399","https://openalex.org/W2039143648","https://openalex.org/W2052983166","https://openalex.org/W2054624670","https://openalex.org/W2061060103","https://openalex.org/W2065283382","https://openalex.org/W2068176376","https://openalex.org/W2071486470","https://openalex.org/W2082667898","https://openalex.org/W2085875005","https://openalex.org/W2106154817","https://openalex.org/W2119817377","https://openalex.org/W2133895526","https://openalex.org/W2145268834","https://openalex.org/W2148047088","https://openalex.org/W2149806742","https://openalex.org/W2152456839","https://openalex.org/W2153983456","https://openalex.org/W2157642353","https://openalex.org/W2158714788","https://openalex.org/W2163352757","https://openalex.org/W2163784018","https://openalex.org/W2171268876","https://openalex.org/W4255170300","https://openalex.org/W6836817746"],"related_works":["https://openalex.org/W2046283209","https://openalex.org/W3041651963","https://openalex.org/W2165762767","https://openalex.org/W2600987503","https://openalex.org/W1618806168","https://openalex.org/W1988268466","https://openalex.org/W1997571629","https://openalex.org/W2155809563","https://openalex.org/W2037519090","https://openalex.org/W2112005097"],"abstract_inverted_index":{"MOTIVATION:":[0],"Human":[1],"Nbs1":[2,62,97,112],"and":[3,50,63,84,98],"its":[4,114],"homolog":[5],"Xrs2":[6,64,99],"in":[7,18,25,35,95,111,127,148],"Saccharomyces":[8],"cerevisiae":[9],"are":[10],"part":[11],"of":[12,53,68,72,91,107,129,144],"the":[13,32,36,48,51,54,57,66,73,89,101,108,122,133,136,141,149],"conserved":[14],"MRN":[15,55],"complex":[16],"(MRX":[17],"yeast)":[19],"which":[20],"plays":[21],"a":[22,43,92,117],"crucial":[23],"role":[24],"maintaining":[26],"genomic":[27],"stability.":[28],"NBS1":[29],"corresponds":[30],"to":[31],"gene":[33,152],"mutated":[34],"Nijmegen":[37],"breakage":[38],"syndrome":[39],"(NBS)":[40],"known":[41],"as":[42,116],"radiation":[44],"hyper-sensitive":[45],"disease.":[46],"Despite":[47],"conservation":[49,105],"importance":[52],"complex,":[56],"high":[58],"sequence":[59],"divergence":[60],"between":[61],"precluded":[65],"identification":[67],"common":[69],"domains":[70],"downstream":[71],"N-terminal":[74],"Fork-Head":[75],"Associated":[76],"(FHA)":[77],"domain.":[78,120],"RESULTS:":[79],"Using":[80],"HMM-HMM":[81],"profile":[82],"comparisons":[83],"structure":[85],"modelling,":[86],"we":[87],"assessed":[88],"existence":[90],"tandem":[93,109,134],"BRCT":[94,110,146],"both":[96],"after":[100],"FHA.":[102],"The":[103],"structure-based":[104],"analysis":[106],"supports":[113],"function":[115],"phosphoserine":[118],"binding":[119],"Remarkably,":[121],"5":[123],"bp":[124],"deletion":[125],"observed":[126],"95%":[128],"NBS":[130],"patients":[131],"cleaves":[132],"at":[135],"linker":[137],"region":[138],"while":[139],"preserving":[140],"structural":[142],"integrity":[143],"each":[145],"domain":[147],"resulting":[150],"truncated":[151],"products.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
