{"id":"https://openalex.org/W2123589347","doi":"https://doi.org/10.1093/bioinformatics/btk047","title":"Combining signals from spotted cDNA microarrays obtained at different scanning intensities","display_name":"Combining signals from spotted cDNA microarrays obtained at different scanning intensities","publication_year":2006,"publication_date":"2006-01-17","ids":{"openalex":"https://openalex.org/W2123589347","doi":"https://doi.org/10.1093/bioinformatics/btk047","mag":"2123589347","pmid":"https://pubmed.ncbi.nlm.nih.gov/16418237"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btk047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/7/802/48841499/bioinformatics_22_7_802.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/7/802/48841499/bioinformatics_22_7_802.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041604104","display_name":"Hans\u2010Peter Piepho","orcid":"https://orcid.org/0000-0001-7813-2992"},"institutions":[{"id":"https://openalex.org/I110079840","display_name":"University of Hohenheim","ror":"https://ror.org/00b1c9541","country_code":"DE","type":"education","lineage":["https://openalex.org/I110079840"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"H. P. Piepho","raw_affiliation_strings":["Bioinformatics Unit, Institute for Crop Production and Grassland Research, University of Hohenheim 1 \u00a0 1 \u00a0 \u00a0 Fruwirthstrasse 23, 70599 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Institute for Crop Production and Grassland Research, University of Hohenheim 1 \u00a0 1 \u00a0 \u00a0 Fruwirthstrasse 23, 70599 Stuttgart, Germany","institution_ids":["https://openalex.org/I110079840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002913960","display_name":"Barbara Keller","orcid":"https://orcid.org/0000-0002-7903-8938"},"institutions":[{"id":"https://openalex.org/I110079840","display_name":"University of Hohenheim","ror":"https://ror.org/00b1c9541","country_code":"DE","type":"education","lineage":["https://openalex.org/I110079840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Keller","raw_affiliation_strings":["Bioinformatics Unit, Institute for Crop Production and Grassland Research, University of Hohenheim 1 \u00a0 1 \u00a0 \u00a0 Fruwirthstrasse 23, 70599 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Institute for Crop Production and Grassland Research, University of Hohenheim 1 \u00a0 1 \u00a0 \u00a0 Fruwirthstrasse 23, 70599 Stuttgart, Germany","institution_ids":["https://openalex.org/I110079840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006223320","display_name":"Nadine Hoecker","orcid":null},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Hoecker","raw_affiliation_strings":["Center for Plant Molecular Biology, Department of General Genetics, University of Tuebingen 2 \u00a0 2 \u00a0 \u00a0 Auf der Morgenstelle 28, 72076 Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Plant Molecular Biology, Department of General Genetics, University of Tuebingen 2 \u00a0 2 \u00a0 \u00a0 Auf der Morgenstelle 28, 72076 Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012793034","display_name":"Frank Hochholdinger","orcid":"https://orcid.org/0000-0002-5155-0884"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Hochholdinger","raw_affiliation_strings":["Center for Plant Molecular Biology, Department of General Genetics, University of Tuebingen 2 \u00a0 2 \u00a0 \u00a0 Auf der Morgenstelle 28, 72076 Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Plant Molecular Biology, Department of General Genetics, University of Tuebingen 2 \u00a0 2 \u00a0 \u00a0 Auf der Morgenstelle 28, 72076 Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041604104"],"corresponding_institution_ids":["https://openalex.org/I110079840"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0805,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75479053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"7","first_page":"802","last_page":"807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5969727039337158},{"id":"https://openalex.org/keywords/complementary-dna","display_name":"Complementary DNA","score":0.5963732004165649},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5814154148101807},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.47578752040863037},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.45642468333244324},{"id":"https://openalex.org/keywords/saturation","display_name":"Saturation (graph theory)","score":0.4129420816898346},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4092143476009369},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3764382302761078},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37014490365982056},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.364709734916687},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28080835938453674},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1977654993534088},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15136852860450745},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10031083226203918},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07602602243423462}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5969727039337158},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5963732004165649},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5814154148101807},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.47578752040863037},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.45642468333244324},{"id":"https://openalex.org/C9930424","wikidata":"https://www.wikidata.org/wiki/Q7426587","display_name":"Saturation (graph theory)","level":2,"score":0.4129420816898346},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4092143476009369},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3764382302761078},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37014490365982056},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.364709734916687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28080835938453674},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1977654993534088},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15136852860450745},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10031083226203918},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07602602243423462},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btk047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/7/802/48841499/bioinformatics_22_7_802.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16418237","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16418237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btk047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk047","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/7/802/48841499/bioinformatics_22_7_802.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2123589347.pdf"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1668720348","https://openalex.org/W1969853681","https://openalex.org/W1991042426","https://openalex.org/W2015682520","https://openalex.org/W2024081693","https://openalex.org/W2061914907","https://openalex.org/W2077843346","https://openalex.org/W2099388441","https://openalex.org/W2101950184","https://openalex.org/W2102000606","https://openalex.org/W2132261436","https://openalex.org/W2153006842","https://openalex.org/W2153399204","https://openalex.org/W2160456513","https://openalex.org/W2489605225","https://openalex.org/W2798142305","https://openalex.org/W2801840425","https://openalex.org/W3212092593","https://openalex.org/W4246673598","https://openalex.org/W4299798163","https://openalex.org/W4300029251","https://openalex.org/W4300066526"],"related_works":["https://openalex.org/W2138721420","https://openalex.org/W3028970346","https://openalex.org/W2266553821","https://openalex.org/W2058443900","https://openalex.org/W2528918625","https://openalex.org/W2387325343","https://openalex.org/W2059471335","https://openalex.org/W2039626633","https://openalex.org/W2089254602","https://openalex.org/W2384648744"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,52,131,172],"analysis":[2],"of":[3,9,45,70,121,154],"spotted":[4,30],"cDNA":[5,126,136],"microarrays":[6],"involves":[7],"scanning":[8,22,62,65],"color":[10],"signals":[11,46,75],"from":[12,47,76,112,139,162],"fluorescent":[13],"dyes.":[14],"A":[15],"common":[16],"problem":[17,53],"is":[18,24,84,133],"that":[19],"a":[20,91],"given":[21],"intensity":[23],"not":[25,85],"usually":[26],"optimal":[27],"for":[28,96,101,125],"all":[29],"cDNAs.":[31],"Specifically,":[32],"some":[33],"spots":[34,127],"may":[35,54],"be":[36,55],"at":[37,177],"the":[38,68,77,105,151,155,163],"saturation":[39,106],"limit,":[40],"resulting":[41],"in":[42,150],"poor":[43],"separation":[44],"different":[48,74],"tissues":[49],"or":[50],"conditions.":[51],"addressed":[56],"by":[57,104],"multiple":[58,113,116],"scans":[59,117],"with":[60,128],"varying":[61],"intensities.":[63],"Multiple":[64],"intensities":[66],"raise":[67],"question":[69],"how":[71],"to":[72],"combine":[73],"same":[78],"spot,":[79],"particularly":[80,124],"when":[81],"measurement":[82],"error":[83,123],"negligible.":[86],"RESULTS:":[87],"This":[88],"paper":[89],"suggests":[90],"non-linear":[92],"latent":[93],"regression":[94],"model":[95],"this":[97],"purpose.":[98],"It":[99],"corrects":[100],"biases":[102],"caused":[103],"limit":[107],"and":[108],"efficiently":[109],"combines":[110],"data":[111,138,174],"scans.":[114],"Combining":[115],"also":[118],"allows":[119],"reduction":[120],"technical":[122],"low":[129],"signal.":[130],"procedure":[132],"exemplified":[134],"using":[135,146],"expression":[137],"maize.":[140],"AVAILABILITY:":[141],"All":[142],"methods":[143],"were":[144],"implemented":[145],"standard":[147],"procedures":[148],"available":[149,161,176],"SAS/STAT":[152],"module":[153],"SAS":[156],"System.":[157],"Programming":[158],"statements":[159],"are":[160,175],"first":[164],"author":[165],"upon":[166],"request.":[167],"CONTACT:":[168],"piepho@uni-hohenheim.de":[169],"SUPPLEMENTARY":[170],"INFORMATION:":[171],"supplementary":[173],"Bioinformatics":[178],"online.":[179]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
