{"id":"https://openalex.org/W1571452812","doi":"https://doi.org/10.1093/bioinformatics/btk017","title":"Bayesian sparse hidden components analysis for transcription regulation networks","display_name":"Bayesian sparse hidden components analysis for transcription regulation networks","publication_year":2005,"publication_date":"2005-12-20","ids":{"openalex":"https://openalex.org/W1571452812","doi":"https://doi.org/10.1093/bioinformatics/btk017","mag":"1571452812","pmid":"https://pubmed.ncbi.nlm.nih.gov/16368767"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btk017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk017","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/6/739/48838945/bioinformatics_22_6_739.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/6/739/48838945/bioinformatics_22_6_739.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037586820","display_name":"Chiara Sabatti","orcid":"https://orcid.org/0000-0001-5829-9058"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chiara Sabatti","raw_affiliation_strings":["Departments of Human Genetics and Statistics, UCLA 1 \u00a0 1 \u00a0 \u00a0 Los Angeles CA 90095-7088, USA","Departments of Human Genetics and Statistics, UCLA Los Angeles, CA 90095-7088, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Genetics and Statistics, UCLA 1 \u00a0 1 \u00a0 \u00a0 Los Angeles CA 90095-7088, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Departments of Human Genetics and Statistics, UCLA Los Angeles, CA 90095-7088, USA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028919793","display_name":"Gareth James","orcid":"https://orcid.org/0000-0002-3031-5906"},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth M. James","raw_affiliation_strings":["Information and Operations Management Department, USC 2 \u00a0 2 \u00a0 \u00a0 Los Angeles, CA 90089-0809, USA","Information and Operations Management Department, USC Los Angeles, CA 90089-0809, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information and Operations Management Department, USC 2 \u00a0 2 \u00a0 \u00a0 Los Angeles, CA 90089-0809, USA","institution_ids":["https://openalex.org/I1342924430"]},{"raw_affiliation_string":"Information and Operations Management Department, USC Los Angeles, CA 90089-0809, USA#TAB#","institution_ids":["https://openalex.org/I1342924430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037586820"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.04896656,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"6","first_page":"739","last_page":"746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7307000160217285,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7307000160217285,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.15530000627040863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6369650363922119},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.6054847240447998},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5626806020736694},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.5579168200492859},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5162737369537354},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.44214341044425964},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4384486973285675},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42807137966156006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4029844105243683},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3823889493942261},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3795333504676819},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33799242973327637},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3169454336166382},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3116588592529297},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.1760430932044983}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6369650363922119},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.6054847240447998},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5626806020736694},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.5579168200492859},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5162737369537354},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.44214341044425964},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4384486973285675},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42807137966156006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4029844105243683},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3823889493942261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3795333504676819},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33799242973327637},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3169454336166382},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3116588592529297},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1760430932044983},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/bioinformatics/btk017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk017","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/6/739/48838945/bioinformatics_22_6_739.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16368767","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16368767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Evaluation Study"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt13p179jr","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/13p179jr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt32m2s8hs","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/32m2s8hs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:qt13p179jr","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/13p179jr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sabatti, Chiara; & James, Gareth. (2005). Bayesian Sparse Hidden Components Analysis for Transcription Regulation Networks. Department of Statistics, UCLA. UCLA: Department of Statistics, UCLA. Retrieved from: http://www.escholarship.org/uc/item/13p179jr","raw_type":"article"},{"id":"pmh:qt32m2s8hs","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/32m2s8hs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chiara Sabatti; & Gareth James. (2011). Bayesian Sparse Hidden Components Analysis for Transcription Regulation Networks. Department of Statistics, UCLA. UCLA: Department of Statistics, UCLA. Retrieved from: http://www.escholarship.org/uc/item/32m2s8hs","raw_type":"article"},{"id":"mag:1571452812","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btk017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk017","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/6/739/48838945/bioinformatics_22_6_739.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1571452812.pdf","grobid_xml":"https://content.openalex.org/works/W1571452812.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1753000577","https://openalex.org/W2005923596","https://openalex.org/W2025086931","https://openalex.org/W2050648928","https://openalex.org/W2069645361","https://openalex.org/W2073727170","https://openalex.org/W2076372398","https://openalex.org/W2076375071","https://openalex.org/W2096139934","https://openalex.org/W2102862543","https://openalex.org/W2124669261","https://openalex.org/W2134092975","https://openalex.org/W2138284860","https://openalex.org/W2140551944","https://openalex.org/W2142182986","https://openalex.org/W2142446963","https://openalex.org/W2144710927","https://openalex.org/W2148541040","https://openalex.org/W2157523980","https://openalex.org/W2163988673","https://openalex.org/W2167190345","https://openalex.org/W6858214765"],"related_works":["https://openalex.org/W2766989661","https://openalex.org/W2096218546","https://openalex.org/W2057632640","https://openalex.org/W2039079365","https://openalex.org/W2008168031","https://openalex.org/W316154794","https://openalex.org/W2096453387","https://openalex.org/W2288964075","https://openalex.org/W2538590841","https://openalex.org/W1998580104","https://openalex.org/W2154706309","https://openalex.org/W2147440110","https://openalex.org/W1549994062","https://openalex.org/W2060338946","https://openalex.org/W2007174592","https://openalex.org/W2010532309","https://openalex.org/W1481287147","https://openalex.org/W2022051435","https://openalex.org/W2117521650","https://openalex.org/W1560863993"],"abstract_inverted_index":{"MOTIVATION:":[0],"In":[1],"systems":[2],"like":[3],"Escherichia":[4],"Coli,":[5],"the":[6,23,29,72,86,96,99,108,118,126,130,134],"abundance":[7],"of":[8,31,65,74,98,117,136,146],"sequence":[9],"information,":[10,57],"gene":[11,35],"expression":[12,61,109,154],"array":[13,110],"studies":[14,155],"and":[15,26,60,85,139],"small":[16],"scale":[17],"experiments":[18],"allows":[19,112],"one":[20],"to":[21,27,80,90,114,152],"reconstruct":[22],"regulatory":[24,100,127],"network":[25],"quantify":[28],"effects":[30],"transcription":[32,67],"factors":[33,68],"on":[34,71,95],"expression.":[36],"However,":[37],"this":[38],"goal":[39],"can":[40],"only":[41],"be":[42],"achieved":[43],"if":[44],"all":[45],"information":[46],"sources":[47],"are":[48,78,88,122,168],"used":[49,79,89,124],"in":[50,129,143,156],"concert.":[51],"RESULTS:":[52],"Our":[53],"method":[54],"integrates":[55],"literature":[56],"DNA":[58],"sequences":[59],"arrays.":[62],"A":[63,102],"set":[64],"relevant":[66],"is":[69],"defined":[70],"basis":[73],"literature.":[75],"Sequence":[76],"data":[77,111],"identify":[81,115],"potential":[82,119],"target":[83],"genes":[84],"results":[87],"define":[91],"a":[92,144],"prior":[93],"distribution":[94],"topology":[97],"network.":[101],"Bayesian":[103],"hidden":[104],"component":[105],"model":[106],"for":[107],"us":[113],"which":[116],"binding":[120],"sites":[121],"actually":[123],"by":[125],"proteins":[128],"studied":[131],"cell":[132],"conditions,":[133],"strength":[135],"their":[137,140],"control,":[138],"activation":[141],"profile":[142],"series":[145],"experiments.":[147],"We":[148],"apply":[149],"our":[150],"methodology":[151],"35":[153],"E.Coli":[157],"with":[158],"convincing":[159],"results.":[160],"AVAILABILITY:":[161],"www.genetics.ucla.edu/labs/sabatti/software.html":[162],"SUPPLEMENTARY":[163],"INFORMATION:":[164],"The":[165],"supplementary":[166],"material":[167],"available":[169],"at":[170],"Bioinformatics":[171],"online.":[172]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}