{"id":"https://openalex.org/W2146737987","doi":"https://doi.org/10.1093/bioinformatics/bti775","title":"Mean curvature as a major determinant of \u03b2-sheet propensity","display_name":"Mean curvature as a major determinant of \u03b2-sheet propensity","publication_year":2005,"publication_date":"2005-11-15","ids":{"openalex":"https://openalex.org/W2146737987","doi":"https://doi.org/10.1093/bioinformatics/bti775","mag":"2146737987","pmid":"https://pubmed.ncbi.nlm.nih.gov/16287940"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti775","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti775","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/3/297/48839675/bioinformatics_22_3_297.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/3/297/48839675/bioinformatics_22_3_297.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078732239","display_name":"Eunhee Koh","orcid":"https://orcid.org/0000-0002-0901-6303"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eunhee Koh","raw_affiliation_strings":["Department of Biology, Yonsei University 1 \u00a0 1 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yonsei University 1 \u00a0 1 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039784111","display_name":"Taehyo Kim","orcid":"https://orcid.org/0000-0001-6224-3890"},"institutions":[{"id":"https://openalex.org/I188068037","display_name":"Pohang Iron and Steel (South Korea)","ror":"https://ror.org/00btvqy64","country_code":"KR","type":"company","lineage":["https://openalex.org/I188068037"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taehyo Kim","raw_affiliation_strings":["POSCO, Technical Research Laboratories 3 \u00a0 3 \u00a0 \u00a0 699, Gumho-dong, Gwangyang-si, Jeonnam, 545-090, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSCO, Technical Research Laboratories 3 \u00a0 3 \u00a0 \u00a0 699, Gumho-dong, Gwangyang-si, Jeonnam, 545-090, Korea","institution_ids":["https://openalex.org/I188068037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103032803","display_name":"Hyun\u2010Soo Cho","orcid":"https://orcid.org/0000-0003-4067-4715"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-soo Cho","raw_affiliation_strings":["Department of Biology, Yonsei University 1 \u00a0 1 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea","Protein Network Research Center, Yonsei University 2 \u00a0 2 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yonsei University 1 \u00a0 1 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Protein Network Research Center, Yonsei University 2 \u00a0 2 \u00a0 \u00a0 134, Sinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078732239"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.457,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84223523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"3","first_page":"297","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curvature","display_name":"Curvature","score":0.8106257915496826},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"Beta sheet","score":0.5543866157531738},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.495234876871109},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.46417662501335144},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.38233059644699097},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32511723041534424},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.3055487871170044},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.2673758864402771},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16140976548194885},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07893809676170349}],"concepts":[{"id":"https://openalex.org/C195065555","wikidata":"https://www.wikidata.org/wiki/Q214881","display_name":"Curvature","level":2,"score":0.8106257915496826},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.5543866157531738},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.495234876871109},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.46417662501335144},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38233059644699097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32511723041534424},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3055487871170044},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.2673758864402771},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16140976548194885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07893809676170349},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti775","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti775","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/3/297/48839675/bioinformatics_22_3_297.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16287940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16287940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti775","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti775","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/3/297/48839675/bioinformatics_22_3_297.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.4699999988079071}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2146737987.pdf"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W59526888","https://openalex.org/W1481529529","https://openalex.org/W1496795942","https://openalex.org/W1541263375","https://openalex.org/W1565212980","https://openalex.org/W1572837413","https://openalex.org/W1600524405","https://openalex.org/W1963550288","https://openalex.org/W1965906560","https://openalex.org/W1966851556","https://openalex.org/W1974694634","https://openalex.org/W1975304761","https://openalex.org/W1986876479","https://openalex.org/W1991653374","https://openalex.org/W2005382196","https://openalex.org/W2008708467","https://openalex.org/W2038794420","https://openalex.org/W2043361746","https://openalex.org/W2054448211","https://openalex.org/W2059567258","https://openalex.org/W2061197399","https://openalex.org/W2061663059","https://openalex.org/W2069852256","https://openalex.org/W2077946227","https://openalex.org/W2085277871","https://openalex.org/W2089344418","https://openalex.org/W2090065141","https://openalex.org/W2090570211","https://openalex.org/W2090882101","https://openalex.org/W2095169134","https://openalex.org/W2112682798","https://openalex.org/W2133232778","https://openalex.org/W2140992384","https://openalex.org/W2177731497","https://openalex.org/W2984066441"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2013082111","https://openalex.org/W2183409606","https://openalex.org/W4248921569","https://openalex.org/W2069852256","https://openalex.org/W2114336786","https://openalex.org/W2102017765","https://openalex.org/W2090443083","https://openalex.org/W2146737987","https://openalex.org/W2020928707"],"abstract_inverted_index":{"MOTIVATION:":[0],"Despite":[1],"the":[2,16,27,57,62,86,97,103,135,142,166,173,181,198],"importance":[3],"of":[4,39,89,99,127,144,149,156,176,202],"beta-sheets":[5],"as":[6,197],"building":[7],"blocks":[8],"in":[9,15,102,139,164,180],"proteins":[10,106],"and":[11,55,178,184],"also":[12],"toxic":[13],"elements":[14],"pathological":[17],"disorders,":[18],"ranging":[19],"from":[20],"Alzheimer's":[21],"disease":[22],"to":[23,77],"mad":[24],"cow":[25],"disease,":[26],"principles":[28],"underlying":[29],"their":[30,47,161],"stability":[31,98,200],"are":[32,170],"not":[33],"well":[34],"understood.":[35],"Non-random":[36],"beta-sheet":[37,75,105,154,168,186,204],"propensities":[38,155],"amino":[40,157],"acids":[41,158],"have":[42],"been":[43],"revealed":[44],"both":[45],"by":[46,56,172],"distinct":[48,182],"statistical":[49,183],"preferences":[50],"within":[51],"known":[52],"protein":[53],"structures":[54],"relative":[58],"thermodynamic":[59,185],"scales":[60],"through":[61],"experimental":[63],"host-guest":[64],"systems.":[65],"However,":[66],"recent":[67],"fitting":[68],"analysis":[69],"has":[70],"proved":[71],"that":[72,96,160,191],"a":[73,78,100,130,203],"native":[74],"conforms":[76],"minimal":[79],"surface":[80],"with":[81,110,124,141,152],"zero":[82],"mean":[83,112,122,150,192],"curvature,":[84],"like":[85],"physical":[87],"model":[88],"soap":[90],"films.":[91],"RESULTS:":[92],"We":[93],"here":[94],"suggest":[95],"residue":[101],"all":[104],"can":[107],"be":[108,195],"measured":[109],"its":[111],"curvature":[113,123,193],"parameter,":[114],"using":[115],"discrete":[116],"differential":[117],"geometry.":[118],"The":[119],"sharply":[120],"decreasing":[121],"increasing":[125],"number":[126,143],"beta-strands":[128],"identifies":[129],"significant":[131,199],"cooperative":[132],"effect":[133],"whereby":[134],"interstrand":[136],"interaction":[137],"increases":[138],"strength":[140],"beta-strands.":[145],"Furthermore,":[146],"strong":[147],"correlations":[148],"curvatures":[151],"previous":[153],"show":[159],"intrinsic":[162],"differences":[163],"adopting":[165],"ideal":[167],"structure":[169],"affected":[171],"water-accessible":[174],"area":[175],"side-chains,":[177],"result":[179],"propensities.":[187],"Therefore,":[188],"we":[189],"conclude":[190],"should":[194],"considered":[196],"index":[201],"structure.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2016-06-24T00:00:00"}