{"id":"https://openalex.org/W2146180248","doi":"https://doi.org/10.1093/bioinformatics/bti772","title":"Accurate anchoring alignment of divergent sequences","display_name":"Accurate anchoring alignment of divergent sequences","publication_year":2005,"publication_date":"2005-11-13","ids":{"openalex":"https://openalex.org/W2146180248","doi":"https://doi.org/10.1093/bioinformatics/bti772","mag":"2146180248","pmid":"https://pubmed.ncbi.nlm.nih.gov/16301203"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti772","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti772","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003273569","display_name":"Weichun Huang","orcid":"https://orcid.org/0000-0002-9149-0599"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weichun Huang","raw_affiliation_strings":["Bioinformatics Research Center, North Carolina State University 2 \u00a0 2 \u00a0 \u00a0 Raleigh, NC 27606 USA","Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA","Institute for Genome Sciences & Policy, Duke University Medical Center 3 \u00a0 3 \u00a0 \u00a0 Durham, NC 27708 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, North Carolina State University 2 \u00a0 2 \u00a0 \u00a0 Raleigh, NC 27606 USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Institute for Genome Sciences & Policy, Duke University Medical Center 3 \u00a0 3 \u00a0 \u00a0 Durham, NC 27708 USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036278452","display_name":"David M. Umbach","orcid":"https://orcid.org/0000-0002-7142-2812"},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Umbach","raw_affiliation_strings":["Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100408451","display_name":"Leping Li","orcid":"https://orcid.org/0000-0003-4208-0259"},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leping Li","raw_affiliation_strings":["Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, The National Institute of Environmental Health Sciences 1 \u00a0 1 \u00a0 \u00a0 RTP, NC 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.4237,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.80218734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"29","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.19030000269412994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.7988049983978271},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.7747528553009033},{"id":"https://openalex.org/keywords/smith\u2013waterman-algorithm","display_name":"Smith\u2013Waterman algorithm","score":0.7326002717018127},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.7177037596702576},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6351600885391235},{"id":"https://openalex.org/keywords/alignment-free-sequence-analysis","display_name":"Alignment-free sequence analysis","score":0.5625240802764893},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5604356527328491},{"id":"https://openalex.org/keywords/dynamic-programming","display_name":"Dynamic programming","score":0.4928576946258545},{"id":"https://openalex.org/keywords/heuristic","display_name":"Heuristic","score":0.48607781529426575},{"id":"https://openalex.org/keywords/structural-alignment","display_name":"Structural alignment","score":0.47866711020469666},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4682546555995941},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43952909111976624},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39313995838165283},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3535262942314148},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.29501450061798096},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2645028531551361},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.15090686082839966},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14886614680290222}],"concepts":[{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.7988049983978271},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.7747528553009033},{"id":"https://openalex.org/C72802188","wikidata":"https://www.wikidata.org/wiki/Q1683352","display_name":"Smith\u2013Waterman algorithm","level":5,"score":0.7326002717018127},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.7177037596702576},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6351600885391235},{"id":"https://openalex.org/C180384323","wikidata":"https://www.wikidata.org/wiki/Q16335137","display_name":"Alignment-free sequence analysis","level":5,"score":0.5625240802764893},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5604356527328491},{"id":"https://openalex.org/C37404715","wikidata":"https://www.wikidata.org/wiki/Q380679","display_name":"Dynamic programming","level":2,"score":0.4928576946258545},{"id":"https://openalex.org/C173801870","wikidata":"https://www.wikidata.org/wiki/Q201413","display_name":"Heuristic","level":2,"score":0.48607781529426575},{"id":"https://openalex.org/C4668613","wikidata":"https://www.wikidata.org/wiki/Q4116110","display_name":"Structural alignment","level":5,"score":0.47866711020469666},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4682546555995941},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43952909111976624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39313995838165283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3535262942314148},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.29501450061798096},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2645028531551361},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.15090686082839966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14886614680290222},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti772","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti772","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16301203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16301203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6600000262260437,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1482360569","https://openalex.org/W1659313070","https://openalex.org/W1966585515","https://openalex.org/W1980397590","https://openalex.org/W1986014242","https://openalex.org/W1991319607","https://openalex.org/W1999909705","https://openalex.org/W2036295979","https://openalex.org/W2039509794","https://openalex.org/W2052831012","https://openalex.org/W2054849588","https://openalex.org/W2055043387","https://openalex.org/W2057998009","https://openalex.org/W2068448872","https://openalex.org/W2071398217","https://openalex.org/W2072603644","https://openalex.org/W2074231493","https://openalex.org/W2082736011","https://openalex.org/W2085442947","https://openalex.org/W2087064593","https://openalex.org/W2095685450","https://openalex.org/W2096204704","https://openalex.org/W2106882534","https://openalex.org/W2110291136","https://openalex.org/W2116688916","https://openalex.org/W2128591967","https://openalex.org/W2132967231","https://openalex.org/W2136145671","https://openalex.org/W2143286856","https://openalex.org/W2144322830","https://openalex.org/W2148311769","https://openalex.org/W2155237411","https://openalex.org/W2158714788","https://openalex.org/W2161387979","https://openalex.org/W2163860567","https://openalex.org/W4293196852","https://openalex.org/W6674650089","https://openalex.org/W6842402754"],"related_works":["https://openalex.org/W2051969447","https://openalex.org/W2468116983","https://openalex.org/W2029514038","https://openalex.org/W2111937814","https://openalex.org/W1486249959","https://openalex.org/W2103737249","https://openalex.org/W2141411672","https://openalex.org/W2122131968","https://openalex.org/W2948014085","https://openalex.org/W1482324242"],"abstract_inverted_index":{"MOTIVATION:":[0],"Obtaining":[1],"high":[2],"quality":[3],"alignments":[4],"of":[5,136,146,169],"divergent":[6,90],"homologous":[7],"sequences":[8,32,80],"for":[9,29,66,89,118,129,187],"cross-species":[10,192],"sequence":[11,22,193,210],"comparison":[12],"remains":[13],"a":[14,19,54,67,73,95,184],"challenge.":[15],"RESULTS:":[16],"We":[17],"propose":[18],"novel":[20],"pairwise":[21],"alignment":[23,120],"algorithm,":[24],"ACANA":[25,44,52,83,102,141,174,182,206],"(ACcurate":[26],"ANchoring":[27],"Alignment),":[28],"aligning":[30],"biological":[31],"at":[33,215],"both":[34],"local":[35,119],"and":[36,77,86,116,121,127,162,208],"global":[37,68,130],"levels.":[38],"Like":[39],"many":[40],"fast":[41],"heuristic":[42],"methods,":[43],"uses":[45,53],"an":[46],"anchoring":[47],"strategy.":[48],"However,":[49],"unlike":[50],"others,":[51],"Smith-Waterman-like":[55],"dynamic":[56],"programming":[57],"algorithm":[58],"to":[59,99,107,113,123,133,158],"recursively":[60],"identify":[61],"near-optimal":[62],"regions":[63,148],"as":[64,150,196],"anchors":[65],"alignment.":[69,131],"Performance":[70],"evaluations":[71],"using":[72],"simulated":[74,96],"benchmark":[75,97],"dataset":[76,98],"real":[78],"promoter":[79,139],"suggest":[81,180],"that":[82,101,181],"is":[84,183],"accurate":[85],"consistent,":[87],"especially":[88],"sequences.":[91],"Specifically,":[92],"we":[93,179],"use":[94],"show":[100],"has":[103],"the":[104,143,166,176],"highest":[105],"sensitivity":[106],"align":[108],"constrained":[109],"functional":[110,189],"sites":[111,201],"compared":[112,122,157],"BLASTZ,":[114],"CHAOS":[115],"DIALIGN":[117,126,161],"AVID,":[124,159],"ClustalW,":[125,160],"LAGAN":[128],"Applied":[132],"6007":[134],"pairs":[135],"human-mouse":[137],"orthologous":[138],"sequences,":[140],"identified":[142,172],"largest":[144],"number":[145],"conserved":[147,170],"(defined":[149],"over":[151,154],"70%":[152],"identity":[153],"100":[155],"bp)":[156],"LAGAN.":[163],"In":[164],"addition,":[165],"average":[167],"length":[168],"region":[171],"by":[173],"was":[175],"longest.":[177],"Thus,":[178],"useful":[185],"tool":[186],"identifying":[188],"elements":[190],"in":[191,202],"analysis,":[194],"such":[195],"predicting":[197],"transcription":[198],"factor":[199],"binding":[200],"non-coding":[203],"DNA.":[204],"AVAILABILITY:":[205],"software":[207],"test":[209],"data":[211],"are":[212],"publicly":[213],"available":[214],"http://BioMedEmpire.org/":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}