{"id":"https://openalex.org/W2156276695","doi":"https://doi.org/10.1093/bioinformatics/bti752","title":"Systematic intervention of transcription for identifying network response to disease and cellular phenotypes","display_name":"Systematic intervention of transcription for identifying network response to disease and cellular phenotypes","publication_year":2005,"publication_date":"2005-11-08","ids":{"openalex":"https://openalex.org/W2156276695","doi":"https://doi.org/10.1093/bioinformatics/bti752","mag":"2156276695","pmid":"https://pubmed.ncbi.nlm.nih.gov/16278241"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti752","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti752","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/1/96/16851780/bti752.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/1/96/16851780/bti752.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074947237","display_name":"Huai Li","orcid":"https://orcid.org/0000-0001-7129-6660"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huai Li","raw_affiliation_strings":["Bioinformatics Unit, Branch of Research Resources, National Institute on Aging \u00a0 NIH, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Branch of Research Resources, National Institute on Aging \u00a0 NIH, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028221595","display_name":"Ming Zhan","orcid":"https://orcid.org/0000-0002-4668-727X"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming Zhan","raw_affiliation_strings":["Bioinformatics Unit, Branch of Research Resources, National Institute on Aging \u00a0 NIH, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Branch of Research Resources, National Institute on Aging \u00a0 NIH, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028221595"],"corresponding_institution_ids":["https://openalex.org/I4210136897"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":1.5535,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8181105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"96","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3580999970436096,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3580999970436096,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.556451141834259},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5396478176116943},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5328270792961121},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5222954750061035},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5184800028800964},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4874613285064697},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4854174554347992},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.44465920329093933},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3564597964286804},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34354475140571594},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2550099790096283},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20593798160552979},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1428442895412445}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.556451141834259},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5396478176116943},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5328270792961121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5222954750061035},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5184800028800964},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4874613285064697},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4854174554347992},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44465920329093933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3564597964286804},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34354475140571594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2550099790096283},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20593798160552979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1428442895412445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bti752","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti752","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/1/96/16851780/bti752.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16278241","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16278241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.919.4705","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.919.4705","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2005/11/08/bioinformatics.bti752.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti752","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti752","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/1/96/16851780/bti752.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156276695.pdf","grobid_xml":"https://content.openalex.org/works/W2156276695.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1481919380","https://openalex.org/W1486595217","https://openalex.org/W1566724097","https://openalex.org/W1970930330","https://openalex.org/W2004117621","https://openalex.org/W2007114975","https://openalex.org/W2008269187","https://openalex.org/W2011031041","https://openalex.org/W2023523181","https://openalex.org/W2030387392","https://openalex.org/W2038012561","https://openalex.org/W2040396943","https://openalex.org/W2042478940","https://openalex.org/W2046989794","https://openalex.org/W2049706987","https://openalex.org/W2058221907","https://openalex.org/W2069898971","https://openalex.org/W2095701698","https://openalex.org/W2098669780","https://openalex.org/W2107638414","https://openalex.org/W2109972881","https://openalex.org/W2110699703","https://openalex.org/W2112656672","https://openalex.org/W2113305236","https://openalex.org/W2132866491","https://openalex.org/W2142631293","https://openalex.org/W2145224695","https://openalex.org/W2156498386","https://openalex.org/W2160533336","https://openalex.org/W2166146113","https://openalex.org/W2167190345","https://openalex.org/W2168399023","https://openalex.org/W2169765391","https://openalex.org/W2171704428","https://openalex.org/W2312804644","https://openalex.org/W2315882600","https://openalex.org/W2611370172","https://openalex.org/W3026026050","https://openalex.org/W6628887588","https://openalex.org/W6642983863","https://openalex.org/W6683085313"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W2509687359","https://openalex.org/W4206945140","https://openalex.org/W2130939068","https://openalex.org/W2135896045","https://openalex.org/W3163717165","https://openalex.org/W2114466827"],"abstract_inverted_index":{"MOTIVATION:":[0],"A":[1],"major":[2],"challenge":[3],"in":[4,39,111,139],"post-genomic":[5],"research":[6],"has":[7],"been":[8],"to":[9,32,42,47,76,86,101,109,152,187],"understand":[10],"how":[11],"physiological":[12],"and":[13,41,49,57,129,147,162,167],"pathological":[14],"phenotypes":[15],"arise":[16],"from":[17,123],"the":[18,34,44,63,102,124,140,143,148,158,188],"networks":[19,38],"of":[20,36,68,72,80,104,142,175],"expressed":[21],"genes.":[22],"Here,":[23],"we":[24],"addressed":[25],"this":[26],"issue":[27],"by":[28],"developing":[29],"an":[30],"algorithm":[31,64,97,125,155],"mimic":[33],"behavior":[35],"regulatory":[37,55],"silico":[40],"identify":[43],"dynamic":[45],"response":[46],"disease":[48],"changing":[50],"cellular":[51],"conditions.":[52],"RESULTS:":[53],"With":[54],"pathway":[56,146,150],"gene":[58],"expression":[59],"data":[60],"as":[61,90,136],"input,":[62],"provides":[65],"quantitative":[66],"assessments":[67],"a":[69,81],"wide":[70],"range":[71],"responses,":[73],"including":[74],"susceptibility":[75],"disease,":[77],"potential":[78],"usefulness":[79],"given":[82],"drug,":[83],"or":[84,93],"consequences":[85],"such":[87],"external":[88],"stimuli":[89],"pharmacological":[91],"interventions":[92],"caloric":[94],"restriction.":[95],"The":[96,120,154,180],"is":[98,183],"particularly":[99],"amenable":[100],"analysis":[103,141],"systems":[105],"that":[106],"are":[107],"difficult":[108],"recapitulate":[110],"vitro,":[112],"yet":[113],"they":[114],"may":[115],"have":[116],"important":[117,164],"clinical":[118],"value.":[119],"hypotheses":[121],"derived":[122],"were":[126,130],"biologically":[127],"relevant":[128],"successfully":[131],"validated":[132],"via":[133],"independent":[134],"experiments,":[135],"illustrated":[137],"here":[138],"leukemia-associated":[144],"BCR-ABL":[145],"insulin/IGF":[149],"related":[151],"longevity.":[153],"correctly":[156],"identified":[157],"leukemia":[159],"drug":[160],"target":[161],"genes":[163],"for":[165],"longevity,":[166],"also":[168],"provided":[169],"new":[170],"insights":[171],"into":[172],"our":[173],"understanding":[174],"these":[176],"two":[177],"processes.":[178],"AVAILABILITY:":[179],"software":[181],"package":[182],"available":[184],"upon":[185],"request":[186],"authors.":[189]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}