{"id":"https://openalex.org/W2136479434","doi":"https://doi.org/10.1093/bioinformatics/bti688","title":"Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues","display_name":"Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues","publication_year":2005,"publication_date":"2005-09-27","ids":{"openalex":"https://openalex.org/W2136479434","doi":"https://doi.org/10.1093/bioinformatics/bti688","mag":"2136479434","pmid":"https://pubmed.ncbi.nlm.nih.gov/16188928"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/23/4205/6137352/bti688.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/23/4205/6137352/bti688.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112147691","display_name":"Shinichiro Wachi","orcid":null},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shinichiro Wachi","raw_affiliation_strings":["Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA. swachi@ucdavis.edu","Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA. swachi@ucdavis.edu","institution_ids":["https://openalex.org/I2803209242"]},{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089304233","display_name":"Ken Y. Yoneda","orcid":"https://orcid.org/0000-0002-9550-445X"},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Yoneda","raw_affiliation_strings":["Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of CaliforniaDavis, CA 95616, USA","Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of CaliforniaDavis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112084233","display_name":"Reen Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reen Wu","raw_affiliation_strings":["Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of CaliforniaDavis, CA 95616, USA","Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of CaliforniaDavis, CA 95616, USA","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Center for Comparative Respiratory Biology and Medicine and Division of Pulmonary/Critical Care Medicine, University of California Davis, CA 95616, USA#TAB#","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112147691"],"corresponding_institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I84218800"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.6837,"has_fulltext":true,"cited_by_count":408,"citation_normalized_percentile":{"value":0.95657198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"21","issue":"23","first_page":"4205","last_page":"4208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.9554264545440674},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7193809151649475},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6773389577865601},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6419715881347656},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6286625862121582},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.518828272819519},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5119410753250122},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4722435176372528},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4618939161300659},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.42043226957321167},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37884950637817383},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20363962650299072}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9554264545440674},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7193809151649475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6773389577865601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6419715881347656},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6286625862121582},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.518828272819519},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5119410753250122},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4722435176372528},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4618939161300659},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.42043226957321167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37884950637817383},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20363962650299072},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bti688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/23/4205/6137352/bti688.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16188928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16188928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:3606897","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4631381","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/23/4205/6137352/bti688.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G5899017060","display_name":null,"funder_award_id":"HL07731","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7213648130","display_name":null,"funder_award_id":"HL077902","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7942816269","display_name":null,"funder_award_id":"HL077315","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136479434.pdf","grobid_xml":"https://content.openalex.org/works/W2136479434.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W238668910","https://openalex.org/W343233802","https://openalex.org/W1486854136","https://openalex.org/W1969761972","https://openalex.org/W1978486653","https://openalex.org/W2015292449","https://openalex.org/W2022128518","https://openalex.org/W2044702943","https://openalex.org/W2065304353","https://openalex.org/W2086595847","https://openalex.org/W2097255042","https://openalex.org/W2104315543","https://openalex.org/W2108238425","https://openalex.org/W2108723074","https://openalex.org/W2109972881","https://openalex.org/W2113019448","https://openalex.org/W2118268969","https://openalex.org/W2124463526","https://openalex.org/W2126760155","https://openalex.org/W2130494035","https://openalex.org/W2130790725","https://openalex.org/W2131994307","https://openalex.org/W2134812217","https://openalex.org/W2136316164","https://openalex.org/W2144014661","https://openalex.org/W2151029688","https://openalex.org/W2163480486","https://openalex.org/W2259802687","https://openalex.org/W4247420482","https://openalex.org/W4294216491"],"related_works":["https://openalex.org/W2769306272","https://openalex.org/W2101998831","https://openalex.org/W1922372990","https://openalex.org/W2032694615","https://openalex.org/W2153577994","https://openalex.org/W2086904135","https://openalex.org/W2162117109","https://openalex.org/W3016389020","https://openalex.org/W2157795344","https://openalex.org/W1970306486"],"abstract_inverted_index":{"This":[0],"analysis":[1,42,78],"reveals":[2],"that":[3,6,39],"the":[4,13,24,37,52,55,61,65,70,81],"genes":[5,26,45],"are":[7,20,31],"differentially":[8],"elevated,":[9],"as":[10],"obtained":[11],"from":[12],"microarray":[14],"gene":[15],"profiling":[16],"data,":[17],"in":[18,86],"cancer":[19,44,87],"well":[21],"connected,":[22],"whereas":[23],"suppressed":[25],"and":[27],"randomly":[28],"selected":[29],"ones":[30],"less":[32],"so.":[33],"These":[34],"results":[35],"support":[36],"notion":[38],"a":[40],"topological":[41],"of":[43,54,57,60,69,74,77],"using":[46],"protein":[47],"interaction":[48],"data":[49],"will":[50],"allow":[51],"placement":[53],"list":[56],"genes,":[58],"often":[59],"disparate":[62],"nature,":[63],"into":[64],"global,":[66],"systematic":[67],"context":[68],"cell.":[71],"The":[72],"result":[73],"this":[75],"type":[76],"may":[79],"provide":[80],"rationale":[82],"for":[83],"therapeutic":[84],"targets":[85],"treatment.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":38}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}