{"id":"https://openalex.org/W2157053750","doi":"https://doi.org/10.1093/bioinformatics/bti654","title":"Computational methods for the design of effective therapies against drug resistant HIV strains","display_name":"Computational methods for the design of effective therapies against drug resistant HIV strains","publication_year":2005,"publication_date":"2005-09-06","ids":{"openalex":"https://openalex.org/W2157053750","doi":"https://doi.org/10.1093/bioinformatics/bti654","mag":"2157053750","pmid":"https://pubmed.ncbi.nlm.nih.gov/16144807"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti654","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/21/3943/50555063/bioinformatics_21_21_3943.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/21/3943/50555063/bioinformatics_21_21_3943.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035497488","display_name":"Niko Beerenwinkel","orcid":"https://orcid.org/0000-0002-0573-6119"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. Beerenwinkel","raw_affiliation_strings":["Department of Mathematics, University of California, Berkeley, CA, USA. niko@math.berkeley.edu","DEPARTMENT OF MATHEMATICS,UNIVERSITY OF CALIFORNIA,BERKELEY,CA,USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Berkeley, CA, USA. niko@math.berkeley.edu","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"DEPARTMENT OF MATHEMATICS,UNIVERSITY OF CALIFORNIA,BERKELEY,CA,USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463966","display_name":"Tobias Sing","orcid":"https://orcid.org/0000-0001-7870-7012"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Sing","raw_affiliation_strings":["Max Planck Institute for Informatics, Saarbru cken, Germany,","Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Saarbru cken, Germany,","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556977","display_name":"Thomas Lengauer","orcid":"https://orcid.org/0000-0003-3801-2640"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Lengauer","raw_affiliation_strings":["Max Planck Institute for Informatics, Saarbru cken, Germany,","Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Saarbru cken, Germany,","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075610512","display_name":"J\u00f6rg Rahnenf\u00fchrer","orcid":"https://orcid.org/0000-0002-8947-440X"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Rahnenfuhrer","raw_affiliation_strings":["Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075842572","display_name":"Kirsten Roomp","orcid":"https://orcid.org/0000-0002-4394-7494"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Roomp","raw_affiliation_strings":["Max Planck Institute for Informatics, Saarbru cken, Germany,","Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Saarbru cken, Germany,","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079168521","display_name":"I. Savenkov","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Savenkov","raw_affiliation_strings":["Max Planck Institute for Informatics, Saarbru cken, Germany,","Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Saarbru cken, Germany,","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Max-Planck-Institute for Informatics, , Saarbr\u00fccken, Germany#TAB#","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110006834","display_name":"R. Fischer","orcid":null},"institutions":[{"id":"https://openalex.org/I2800451603","display_name":"Center of Advanced European Studies and Research","ror":"https://ror.org/05350h943","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2800451603"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Fischer","raw_affiliation_strings":["Center of Advanced European Studies and Research, Bonn, Germany,","\u00a7Center of Advanced European Studies and Research, Bonn, Germany;"],"affiliations":[{"raw_affiliation_string":"Center of Advanced European Studies and Research, Bonn, Germany,","institution_ids":["https://openalex.org/I2800451603"]},{"raw_affiliation_string":"\u00a7Center of Advanced European Studies and Research, Bonn, Germany;","institution_ids":["https://openalex.org/I2800451603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074555350","display_name":"Daniel Hoffmann","orcid":"https://orcid.org/0000-0003-2973-7869"},"institutions":[{"id":"https://openalex.org/I2800451603","display_name":"Center of Advanced European Studies and Research","ror":"https://ror.org/05350h943","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2800451603"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Hoffmann","raw_affiliation_strings":["Center of Advanced European Studies and Research, Bonn, Germany,","\u00a7Center of Advanced European Studies and Research, Bonn, Germany;"],"affiliations":[{"raw_affiliation_string":"Center of Advanced European Studies and Research, Bonn, Germany,","institution_ids":["https://openalex.org/I2800451603"]},{"raw_affiliation_string":"\u00a7Center of Advanced European Studies and Research, Bonn, Germany;","institution_ids":["https://openalex.org/I2800451603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034181383","display_name":"Joachim Selbig","orcid":null},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Selbig","raw_affiliation_strings":["Max Planck Institute of Molecular Plant Physiology and University of Potsdam, Germany,","Max Planck Institute of Molecular Plant Physiology and University of Potsdam Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology and University of Potsdam, Germany,","institution_ids":["https://openalex.org/I4210105972","https://openalex.org/I176453806"]},{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology and University of Potsdam Germany#TAB#","institution_ids":["https://openalex.org/I4210105972","https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086466371","display_name":"Klaus Korn","orcid":"https://orcid.org/0000-0003-1891-2107"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Korn","raw_affiliation_strings":["Institute of Clinical and Molecular Virology, University of Erlangen-Nu rnberg, Erlangen, Germany,","Institute of Clinical and Molecular Virology, University of Erlangen-N\u00fcrnberg Erlangen, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Molecular Virology, University of Erlangen-Nu rnberg, Erlangen, Germany,","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Clinical and Molecular Virology, University of Erlangen-N\u00fcrnberg Erlangen, Germany#TAB#","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054161290","display_name":"Henrik Walter","orcid":"https://orcid.org/0000-0002-9403-6121"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Walter","raw_affiliation_strings":["Institute of Clinical and Molecular Virology, University of Erlangen-Nu rnberg, Erlangen, Germany,","Institute of Clinical and Molecular Virology, University of Erlangen-N\u00fcrnberg Erlangen, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Molecular Virology, University of Erlangen-Nu rnberg, Erlangen, Germany,","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Clinical and Molecular Virology, University of Erlangen-N\u00fcrnberg Erlangen, Germany#TAB#","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082309779","display_name":"Thomas Berg","orcid":"https://orcid.org/0000-0003-0003-6241"},"institutions":[{"id":"https://openalex.org/I4210091434","display_name":"MSB Medical School Berlin","ror":"https://ror.org/001vjqx13","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210091434"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Berg","raw_affiliation_strings":["Medical Laboratory, Berlin, Germany,","Medical Laboratory Berlin, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Medical Laboratory, Berlin, Germany,","institution_ids":["https://openalex.org/I4210091434"]},{"raw_affiliation_string":"Medical Laboratory Berlin, Germany#TAB#","institution_ids":["https://openalex.org/I4210091434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088359089","display_name":"Patrick Braun","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Braun","raw_affiliation_strings":["PZB, Aachen, Germany,","PZB Aachen, Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"PZB, Aachen, Germany,","institution_ids":[]},{"raw_affiliation_string":"PZB Aachen, Germany#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108088143","display_name":"Gerd F\u00e4tkenheuer","orcid":null},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Fatkenheuer","raw_affiliation_strings":["Department of Internal Medicine, University of Cologne, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025348858","display_name":"Mark Oette","orcid":null},"institutions":[{"id":"https://openalex.org/I75356249","display_name":"Hochschule D\u00fcsseldorf University of Applied Sciences","ror":"https://ror.org/00ftx0026","country_code":"DE","type":"education","lineage":["https://openalex.org/I75356249"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Oette","raw_affiliation_strings":["Department of Gastroenterology, University of Du sseldorf, Germany and","Department of Gastroenterology, University of Dusseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University of Du sseldorf, Germany and","institution_ids":["https://openalex.org/I75356249","https://openalex.org/I4210089242"]},{"raw_affiliation_string":"Department of Gastroenterology, University of Dusseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054617732","display_name":"J\u00fcrgen K. Rockstroh","orcid":"https://orcid.org/0000-0003-2858-3888"},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Rockstroh","raw_affiliation_strings":["Department of Internal Medicine and","Department of Internal Medicine, University of Bonn Germany#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, University of Bonn Germany#TAB#","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046595058","display_name":"Bernd Kupfer","orcid":null},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Kupfer","raw_affiliation_strings":["Institute of Medical Microbiology and Immunology, University of Bonn, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Immunology, University of Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420045","display_name":"Rolf Kaiser","orcid":"https://orcid.org/0000-0002-2640-2548"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Kaiser","raw_affiliation_strings":["Institute of Virology, University of Cologne, Germany and","Institute of Virology, University of Cologne Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, Germany and","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Virology, University of Cologne Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000627402","display_name":"Martin D\u00e4umer","orcid":null},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Daumer","raw_affiliation_strings":["Institute of Virology, University of Cologne, Germany and","Institute of Virology, University of Cologne Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, Germany and","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Virology, University of Cologne Germany","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5035497488"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":2.9862,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.92100098,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"21","first_page":"3943","last_page":"3950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.7163903117179871},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.6491521596908569},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.596015989780426},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.595906674861908},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5547352433204651},{"id":"https://openalex.org/keywords/antiretroviral-drug","display_name":"Antiretroviral drug","score":0.506674587726593},{"id":"https://openalex.org/keywords/obstacle","display_name":"Obstacle","score":0.4983031749725342},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.4759387969970703},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.45646798610687256},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44777366518974304},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.3872019052505493},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3734002113342285},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3710990250110626},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36243003606796265},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2933422327041626},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.17041346430778503},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.16566190123558044},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10686030983924866}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.7163903117179871},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6491521596908569},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.596015989780426},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.595906674861908},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5547352433204651},{"id":"https://openalex.org/C3018457394","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral drug","level":5,"score":0.506674587726593},{"id":"https://openalex.org/C2776650193","wikidata":"https://www.wikidata.org/wiki/Q264661","display_name":"Obstacle","level":2,"score":0.4983031749725342},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4759387969970703},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.45646798610687256},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44777366518974304},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3872019052505493},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3734002113342285},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3710990250110626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36243003606796265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2933422327041626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17041346430778503},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.16566190123558044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10686030983924866},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004346","descriptor_name":"Drug Information Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004346","descriptor_name":"Drug Information Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004346","descriptor_name":"Drug Information Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/bioinformatics/bti654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti654","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/21/3943/50555063/bioinformatics_21_21_3943.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16144807","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16144807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:edoc.mpg.de:251075","is_oa":false,"landing_page_url":"http://edoc.mpg.de/251075","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, v.21, 3943-3950 (2005)","raw_type":"Article"},{"id":"pmh:oai:edoc.mpg.de:279064","is_oa":false,"landing_page_url":"http://edoc.mpg.de/279064","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, v.21, 3943-3950 (2005)","raw_type":"Article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:13495","is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/13495","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:orbilu.uni.lu:10993/26994","is_oa":false,"landing_page_url":"https://orbilu.uni.lu/handle/10993/26994","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 21(21), 3943-50. Oxford, United Kingdom: Oxford University Press - Journals Department (2005).","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1328858","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-261A-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1816575","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0014-2C1E-B","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti654","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti654","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/21/3943/50555063/bioinformatics_21_21_3943.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G5106512922","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6024419964","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6052429835","display_name":null,"funder_award_id":"(DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8935293790","display_name":"Verbundprojekt: Nationales Genomforschungsnetz, 2. Phase, SMP-Bioinformatik, Anteil MPI f\u00fcr Informatik, Saarbr\u00fccken","funder_award_id":"01GR0453","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157053750.pdf","grobid_xml":"https://content.openalex.org/works/W2157053750.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W15969640","https://openalex.org/W192016177","https://openalex.org/W856957529","https://openalex.org/W1491468287","https://openalex.org/W1492020089","https://openalex.org/W1510295176","https://openalex.org/W1988215875","https://openalex.org/W2012356776","https://openalex.org/W2021733025","https://openalex.org/W2042536531","https://openalex.org/W2050621055","https://openalex.org/W2054331494","https://openalex.org/W2054688372","https://openalex.org/W2067419109","https://openalex.org/W2069572775","https://openalex.org/W2080237955","https://openalex.org/W2081102456","https://openalex.org/W2087730348","https://openalex.org/W2097971319","https://openalex.org/W2102106021","https://openalex.org/W2104275641","https://openalex.org/W2116844530","https://openalex.org/W2122799540","https://openalex.org/W2123576600","https://openalex.org/W2125887450","https://openalex.org/W2127020454","https://openalex.org/W2138925491","https://openalex.org/W2142378830","https://openalex.org/W2145126338","https://openalex.org/W2146003485","https://openalex.org/W2150215096","https://openalex.org/W2159628402","https://openalex.org/W2170987946","https://openalex.org/W2171365066","https://openalex.org/W2396474699","https://openalex.org/W2485374538","https://openalex.org/W2610167300","https://openalex.org/W2939004619","https://openalex.org/W4236265204","https://openalex.org/W4236479494","https://openalex.org/W4297914773"],"related_works":["https://openalex.org/W2612417279","https://openalex.org/W3047978686","https://openalex.org/W2781793960","https://openalex.org/W4291127565","https://openalex.org/W2030780286","https://openalex.org/W2615822851","https://openalex.org/W2325752796","https://openalex.org/W2136637937","https://openalex.org/W4380150288","https://openalex.org/W223382145"],"abstract_inverted_index":{"The":[0,15],"development":[1],"of":[2,12,19,51],"drug":[3,36],"resistance":[4],"is":[5],"a":[6],"major":[7],"obstacle":[8],"to":[9],"successful":[10],"treatment":[11],"HIV":[13,20],"infection.":[14],"extraordinary":[16],"replication":[17],"dynamics":[18],"facilitates":[21],"its":[22],"escape":[23],"from":[24],"selective":[25],"pressure":[26],"exerted":[27],"by":[28,34],"the":[29,49],"human":[30],"immune":[31],"system":[32],"and":[33],"combination":[35],"therapy.":[37],"We":[38],"have":[39],"developed":[40],"several":[41],"computational":[42],"methods":[43],"whose":[44],"combined":[45],"use":[46],"can":[47],"support":[48],"design":[50],"optimal":[52],"antiretroviral":[53],"therapies":[54],"based":[55],"on":[56],"viral":[57],"genomic":[58],"data.":[59]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}