{"id":"https://openalex.org/W2136714708","doi":"https://doi.org/10.1093/bioinformatics/bti638","title":"DNA microarray data imputation and significance analysis of differential expression","display_name":"DNA microarray data imputation and significance analysis of differential expression","publication_year":2005,"publication_date":"2005-08-23","ids":{"openalex":"https://openalex.org/W2136714708","doi":"https://doi.org/10.1093/bioinformatics/bti638","mag":"2136714708","pmid":"https://pubmed.ncbi.nlm.nih.gov/16118262"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti638","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti638","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/22/4155/16840926/bti638.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/22/4155/16840926/bti638.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050648584","display_name":"Rebecka J\u00f6rnsten","orcid":"https://orcid.org/0000-0002-2550-3494"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecka J\u00f6rnsten","raw_affiliation_strings":["Department of Statistics, Rutgers, the State University of New Jersey 1 \u00a0 1 \u00a0 \u00a0 New Brunswick, NJ 08903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rutgers, the State University of New Jersey 1 \u00a0 1 \u00a0 \u00a0 New Brunswick, NJ 08903, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053871316","display_name":"Hui-Yu Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Yu Wang","raw_affiliation_strings":["2 \u00a02 \u00a09 Stoecker Road, Holmdel, NJ 07733, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 \u00a02 \u00a09 Stoecker Road, Holmdel, NJ 07733, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069238430","display_name":"William J. Welsh","orcid":"https://orcid.org/0000-0002-5618-2072"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J. Welsh","raw_affiliation_strings":["Department of Pharmacology, Robert Wood Johnson Medical School, and Informatics Institute, University of Medicine and Dentistry of New Jersey 3 \u00a0 3 \u00a0 \u00a0 Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Robert Wood Johnson Medical School, and Informatics Institute, University of Medicine and Dentistry of New Jersey 3 \u00a0 3 \u00a0 \u00a0 Piscataway, NJ 08854, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101774982","display_name":"Ming Ouyang","orcid":"https://orcid.org/0009-0004-6549-2891"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ming Ouyang","raw_affiliation_strings":["Department of Pharmacology, Robert Wood Johnson Medical School, and Informatics Institute, University of Medicine and Dentistry of New Jersey 3 \u00a0 3 \u00a0 \u00a0 Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Robert Wood Johnson Medical School, and Informatics Institute, University of Medicine and Dentistry of New Jersey 3 \u00a0 3 \u00a0 \u00a0 Piscataway, NJ 08854, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050648584","https://openalex.org/A5101774982"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.2652,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.92472452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"22","first_page":"4155","last_page":"4161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9226999878883362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9226999878883362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.8807650208473206},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.8743488788604736},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5710780620574951},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5637581944465637},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4501792788505554},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.44899293780326843},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26740092039108276}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.8807650208473206},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.8743488788604736},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5710780620574951},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5637581944465637},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4501792788505554},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.44899293780326843},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26740092039108276}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti638","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti638","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/22/4155/16840926/bti638.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16118262","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16118262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti638","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti638","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/22/4155/16840926/bti638.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G613231914","display_name":null,"funder_award_id":"G08 LM06230-03A1","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1967053372","https://openalex.org/W1969289662","https://openalex.org/W2029441111","https://openalex.org/W2049633694","https://openalex.org/W2082503527","https://openalex.org/W2096863518","https://openalex.org/W2105912300","https://openalex.org/W2109205571","https://openalex.org/W2110065044","https://openalex.org/W2111104102","https://openalex.org/W2114933215","https://openalex.org/W2117190895","https://openalex.org/W2119253710","https://openalex.org/W2123987664","https://openalex.org/W2133111499","https://openalex.org/W2133210805","https://openalex.org/W2144227498","https://openalex.org/W2150926065","https://openalex.org/W2160091849","https://openalex.org/W2171118759","https://openalex.org/W2171802582"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W3028371478","https://openalex.org/W2081476516","https://openalex.org/W2581984549","https://openalex.org/W3123177881"],"abstract_inverted_index":{"MOTIVATION:":[0],"Significance":[1],"analysis":[2,107],"of":[3,15,39,43,48,53,108,129,141,144,155,208,225,253,262],"differential":[4,109],"expression":[5],"in":[6,127,242],"DNA":[7,80],"microarray":[8,81,263],"data":[9,41,160,180,264],"is":[10,19,30,57,120,200,295,308],"an":[11,259],"important":[12],"task.":[13],"Much":[14],"the":[16,36,40,49,70,123,138,142,153,156,159,179,206,231,235,243,251,302,313],"current":[17],"research":[18],"focused":[20],"on":[21,86,174,194,310],"developing":[22],"improved":[23],"tests":[24],"and":[25,102,234,238,256,273,283,289],"software":[26],"tools.":[27],"The":[28,266,292],"task":[29],"difficult":[31],"not":[32,90],"only":[33],"owing":[34],"to":[35,62,69,122,152,204],"high":[37,287],"dimensionality":[38],"(number":[42],"genes),":[44],"but":[45,83],"also":[46,213],"because":[47],"often":[50],"non-negligible":[51],"presence":[52],"missing":[54,66,100,168,188,216,226,254,299],"values.":[55],"There":[56],"thus":[58],"a":[59,114,201],"great":[60],"need":[61],"reliably":[63],"impute":[64],"these":[65],"values":[67,101,217,255,300],"prior":[68],"statistical":[71,87],"analyses.":[72],"Many":[73],"imputation":[74,104,116,176,196,210,229,249,276],"methods":[75,126,269],"have":[76],"been":[77,91],"developed":[78],"for":[79],"data,":[82],"their":[84,103],"impact":[85,252],"analyses":[88],"has":[89],"well":[92],"studied.":[93],"In":[94],"this":[95],"work":[96],"we":[97],"examine":[98],"how":[99],"affect":[105,218],"significance":[106,219],"expression.":[110],"RESULTS:":[111],"We":[112,147,212,245],"develop":[113],"new":[115],"method":[117],"(LinCmb)":[118],"that":[119,149,215,247],"superior":[121],"widely":[124],"used":[125],"terms":[128],"normalized":[130],"root":[131],"mean":[132],"squared":[133],"error.":[134],"Its":[135],"estimates":[136,143],"are":[137,161,166,181,186,240,270],"convex":[139],"combinations":[140],"existing":[145],"methods.":[146,197,211],"find":[148],"LinCmb":[150,170,190,199],"adapts":[151],"structure":[154],"data:":[157],"If":[158],"heterogeneous":[162],"or":[163,183],"if":[164,178,184],"there":[165,185],"few":[167],"values,":[169,189,227],"puts":[171,191],"more":[172,192],"weight":[173,193],"local":[175],"methods;":[177],"homogeneous":[182],"many":[187],"global":[195],"Thus,":[198],"useful":[202],"tool":[203],"understand":[205],"merits":[207],"different":[209,223,228],"demonstrate":[214],"analysis.":[220,265],"Two":[221],"datasets,":[222],"amounts":[224],"methods,":[230],"standard":[232,303],"t-test":[233,237,294],"regularized":[236,293],"ANOVA":[239],"employed":[241],"simulations.":[244],"conclude":[246],"good":[248],"alleviates":[250],"should":[257],"be":[258],"integral":[260],"part":[261],"most":[267],"competitive":[268],"LinCmb,":[271],"GMC":[272],"BPCA.":[274],"Popular":[275],"schemes":[277],"such":[278],"as":[279],"SVD,":[280],"row":[281],"mean,":[282],"KNN":[284],"all":[285],"exhibit":[286],"variance":[288],"poor":[290],"performance.":[291],"less":[296],"affected":[297],"by":[298],"than":[301],"t-test.":[304],"AVAILABILITY:":[305],"Matlab":[306],"code":[307],"available":[309],"request":[311],"from":[312],"authors.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}