{"id":"https://openalex.org/W2147736120","doi":"https://doi.org/10.1093/bioinformatics/bti522","title":"Prediction of protein-protein interactions using distant conservation of sequence patterns and structure relationships","display_name":"Prediction of protein-protein interactions using distant conservation of sequence patterns and structure relationships","publication_year":2005,"publication_date":"2005-06-16","ids":{"openalex":"https://openalex.org/W2147736120","doi":"https://doi.org/10.1093/bioinformatics/bti522","mag":"2147736120","pmid":"https://pubmed.ncbi.nlm.nih.gov/15961445"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti522","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti522","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/16/3360/570108/bti522.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/16/3360/570108/bti522.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044431149","display_name":"Jordi Espadaler","orcid":"https://orcid.org/0000-0002-0128-8363"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Espadaler","raw_affiliation_strings":["Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grup de Bioinform\u00e0tica Estructural (GRIB-IMIM), Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046700502","display_name":"Oriol Romero\u2010Isart","orcid":"https://orcid.org/0000-0003-4006-3391"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Romero-Isart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015550435","display_name":"Richard M. Jackson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. M. Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111840557","display_name":"Baldo Oliva","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Oliva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044431149"],"corresponding_institution_ids":["https://openalex.org/I170486558"],"apc_list":null,"apc_paid":null,"fwci":4.551,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.95442438,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"21","issue":"16","first_page":"3360","last_page":"3368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.970300018787384,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.970300018787384,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5995927453041077},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5813639163970947},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5445312857627869},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.533155083656311},{"id":"https://openalex.org/keywords/intersection","display_name":"Intersection (aeronautics)","score":0.49347245693206787},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4673379361629486},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.45418205857276917},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4522746205329895},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.4504094421863556},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.44681763648986816},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.4257577061653137},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41140252351760864},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.32336342334747314},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3156663775444031},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.263116717338562},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13113853335380554}],"concepts":[{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5995927453041077},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5813639163970947},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5445312857627869},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.533155083656311},{"id":"https://openalex.org/C64543145","wikidata":"https://www.wikidata.org/wiki/Q162942","display_name":"Intersection (aeronautics)","level":2,"score":0.49347245693206787},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4673379361629486},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.45418205857276917},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4522746205329895},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.4504094421863556},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.44681763648986816},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4257577061653137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41140252351760864},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.32336342334747314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3156663775444031},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.263116717338562},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13113853335380554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti522","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti522","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/16/3360/570108/bti522.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15961445","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15961445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti522","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti522","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/16/3360/570108/bti522.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1974156712","https://openalex.org/W1991071802","https://openalex.org/W2004981595","https://openalex.org/W2039063819","https://openalex.org/W2057885377","https://openalex.org/W2060584527","https://openalex.org/W2065304353","https://openalex.org/W2080182143","https://openalex.org/W2084367350","https://openalex.org/W2084619201","https://openalex.org/W2094090446","https://openalex.org/W2106391842","https://openalex.org/W2107424557","https://openalex.org/W2109715166","https://openalex.org/W2109899437","https://openalex.org/W2113654464","https://openalex.org/W2124354935","https://openalex.org/W2124463526","https://openalex.org/W2125725297","https://openalex.org/W2128888818","https://openalex.org/W2129558039","https://openalex.org/W2130687290","https://openalex.org/W2131094547","https://openalex.org/W2144563318","https://openalex.org/W2151831732","https://openalex.org/W2154139219","https://openalex.org/W2156070536","https://openalex.org/W2158714788","https://openalex.org/W2160223331","https://openalex.org/W2160690759","https://openalex.org/W2164391585","https://openalex.org/W2168770860","https://openalex.org/W2169356867","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W2889660853","https://openalex.org/W2411047100","https://openalex.org/W2181394498","https://openalex.org/W2287132924","https://openalex.org/W2131407941","https://openalex.org/W2125650596","https://openalex.org/W2586268529","https://openalex.org/W2108768153","https://openalex.org/W1977065177","https://openalex.org/W1797688090"],"abstract_inverted_index":{"MOTIVATION:":[0],"Given":[1],"that":[2,31,181],"association":[3],"and":[4,84,123,234],"dissociation":[5],"of":[6,35,47,54,66,72,80,86,88,108,129,152,173,192,214,229,231,239],"protein":[7,98,155,175,186,194],"molecules":[8],"is":[9,116],"crucial":[10],"in":[11,16,41,77,92,143,205,220],"most":[12],"biological":[13],"processes":[14],"several":[15],"silico":[17],"methods":[18,233],"have":[19,103],"been":[20],"recently":[21],"developed":[22],"to":[23,95,135,200],"predict":[24,96],"protein-protein":[25,93,110],"interactions.":[26,242],"Structural":[27],"evidence":[28],"has":[29],"shown":[30],"usually":[32],"interacting":[33,58,74,140,193],"pairs":[34,87,156,176,195],"close":[36],"homologs":[37],"(interologs)":[38],"physically":[39],"interact":[40],"the":[42,52,55,78,127,153,165,206,215,221,227],"same":[43],"way.":[44],"Moreover,":[45],"conservation":[46,53,85],"an":[48],"interaction":[49,99,111],"depends":[50],"on":[51],"interface":[56],"between":[57,226],"partners.":[59],"In":[60],"this":[61],"article":[62],"we":[63],"make":[64],"use":[65],"both,":[67],"structural":[68],"similarities":[69],"among":[70],"domains":[71],"known":[73,139],"proteins":[75,141],"found":[76,142],"Database":[79,169],"Interacting":[81],"Proteins":[82],"(DIP)":[83],"sequence":[89],"patches":[90],"involved":[91],"interfaces":[94],"putative":[97,109],"pairs.":[100,187],"RESULTS:":[101],"We":[102,125],"obtained":[104],"a":[105,149,189,237],"large":[106],"amount":[107],"(approximately":[112],"130,000).":[113],"The":[114,171,224],"list":[115,128],"independent":[117],"from":[118],"other":[119,232],"techniques":[120],"both":[121],"experimental":[122],"theoretical.":[124],"separated":[126],"predictions":[130],"into":[131],"three":[132],"sets":[133],"according":[134],"their":[136],"relationship":[137],"with":[138,164,198,218],"DIP.":[144],"For":[145],"each":[146],"set,":[147],"only":[148],"small":[150],"fraction":[151,172],"predicted":[154,216],"could":[157],"be":[158],"independently":[159],"validated":[160,174],"by":[161,183],"cross":[162],"checking":[163],"Human":[166],"Protein":[167],"Reference":[168],"(HPRD).":[170],"was":[177,196],"always":[178],"larger":[179],"than":[180],"expected":[182],"using":[184],"random":[185],"Furthermore,":[188],"correlation":[190],"map":[191],"calculated":[197],"respect":[199],"molecular":[201],"function,":[202],"as":[203],"defined":[204],"Gene":[207],"Ontology":[208],"database.":[209,223],"It":[210],"shows":[211],"good":[212],"consistency":[213],"interactions":[217,230],"data":[219],"HPRD":[222],"intersection":[225],"lists":[228],"ours":[235],"produces":[236],"network":[238],"potentially":[240],"high-confidence":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}
