{"id":"https://openalex.org/W2131315497","doi":"https://doi.org/10.1093/bioinformatics/bti429","title":"A protocol for building and evaluating predictors of disease state based on microarray data","display_name":"A protocol for building and evaluating predictors of disease state based on microarray data","publication_year":2005,"publication_date":"2005-04-07","ids":{"openalex":"https://openalex.org/W2131315497","doi":"https://doi.org/10.1093/bioinformatics/bti429","mag":"2131315497","pmid":"https://pubmed.ncbi.nlm.nih.gov/15817694"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti429","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti429","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/19/3755/48980870/bioinformatics_21_19_3755.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/19/3755/48980870/bioinformatics_21_19_3755.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020129085","display_name":"Lodewyk F.A. Wessels","orcid":"https://orcid.org/0000-0002-1656-6995"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"L. F. A. Wessels","raw_affiliation_strings":["Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands. l.f.a.wessels@ewi.tudelft.nl","Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands. l.f.a.wessels@ewi.tudelft.nl","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052699801","display_name":"Marcel Reinders","orcid":"https://orcid.org/0000-0002-1148-1562"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. J. T. Reinders","raw_affiliation_strings":["Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109104866","display_name":"A.A.M. Hart","orcid":null},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. A. M. Hart","raw_affiliation_strings":["Department of Radiotherapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013179642","display_name":"Cor J. Veenman","orcid":"https://orcid.org/0000-0002-2645-1198"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. J. Veenman","raw_affiliation_strings":["Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mediamatics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology Mekelweg 4, 2628 CD Delft, The Netherlands#TAB#","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101790054","display_name":"H. Dai","orcid":"https://orcid.org/0000-0001-6840-8027"},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Dai","raw_affiliation_strings":["Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc.) 401 Terry Avenue N. Seattle, Washington 98109, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc.) 401 Terry Avenue N. Seattle, Washington 98109, USA#TAB#","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440725","display_name":"Yudong D. He","orcid":"https://orcid.org/0000-0003-0818-605X"},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. D. He","raw_affiliation_strings":["Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc.) 401 Terry Avenue N. Seattle, Washington 98109, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc.) 401 Terry Avenue N. Seattle, Washington 98109, USA#TAB#","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014135109","display_name":"Laura van \u2018t Veer","orcid":"https://orcid.org/0000-0002-9838-8298"},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. J. v. Veer","raw_affiliation_strings":["Department of Pathology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5020129085"],"corresponding_institution_ids":["https://openalex.org/I98358874"],"apc_list":null,"apc_paid":null,"fwci":4.5508,"has_fulltext":true,"cited_by_count":148,"citation_normalized_percentile":{"value":0.95425381,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"21","issue":"19","first_page":"3755","last_page":"3762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.7533723711967468},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6123397350311279},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.5933828353881836},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.43371981382369995},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.430032342672348},{"id":"https://openalex.org/keywords/microarray-databases","display_name":"Microarray databases","score":0.4231623709201813},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.2106373906135559},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18410277366638184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16119524836540222},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10581091046333313},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0921449363231659},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.06958422064781189}],"concepts":[{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.7533723711967468},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6123397350311279},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.5933828353881836},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.43371981382369995},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.430032342672348},{"id":"https://openalex.org/C548314002","wikidata":"https://www.wikidata.org/wiki/Q6839218","display_name":"Microarray databases","level":5,"score":0.4231623709201813},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.2106373906135559},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18410277366638184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16119524836540222},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10581091046333313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0921449363231659},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06958422064781189},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012986","descriptor_name":"Software Validation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012986","descriptor_name":"Software Validation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012986","descriptor_name":"Software Validation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/bti429","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti429","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/19/3755/48980870/bioinformatics_21_19_3755.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15817694","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15817694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/3085c3fe-f121-4f63-9c4a-bb2948d46ec4","is_oa":false,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/a-protocol-for-building-and-evaluating-predictors-of-disease-state-based-on-microarray-data(3085c3fe-f121-4f63-9c4a-bb2948d46ec4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wessels, L F A, Reinders, M J T, Hart, A A M, Veenman, C J, Dai, H, He, T & van 't Veer, L J 2005, 'A protocol for building and evaluating predictors of disease state based on microarray data', Bioinformatics, vol. 21, no. 19, pp. 3755-3762. https://doi.org/10.1093/bioinformatics/bti429","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:dare.uva.nl:publications/3085c3fe-f121-4f63-9c4a-bb2948d46ec4","is_oa":false,"landing_page_url":"http://dare.uva.nl/personal/pure/en/publications/a-protocol-for-building-and-evaluating-predictors-of-disease-state-based-on-microarray-data(3085c3fe-f121-4f63-9c4a-bb2948d46ec4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wessels, L F A, Reinders, M J T, Hart, A A M, Veenman, C J, Dai, H, He, T & van 't Veer, L J 2005, 'A protocol for building and evaluating predictors of disease state based on microarray data', Bioinformatics, vol. 21, no. 19, pp. 3755-3762. https://doi.org/10.1093/bioinformatics/bti429","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/3085c3fe-f121-4f63-9c4a-bb2948d46ec4","is_oa":false,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/a-protocol-for-building-and-evaluating-predictors-of-disease-state-based-on-microarray-data(3085c3fe-f121-4f63-9c4a-bb2948d46ec4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 21(19), 3755 - 3762. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti429","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti429","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/19/3755/48980870/bioinformatics_21_19_3755.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2131315497.pdf","grobid_xml":"https://content.openalex.org/works/W2131315497.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1506281249","https://openalex.org/W1727290854","https://openalex.org/W1966701961","https://openalex.org/W1974358221","https://openalex.org/W1980626566","https://openalex.org/W2001619934","https://openalex.org/W2008233728","https://openalex.org/W2017337590","https://openalex.org/W2043235003","https://openalex.org/W2087684630","https://openalex.org/W2088851040","https://openalex.org/W2096763239","https://openalex.org/W2107956883","https://openalex.org/W2108043112","https://openalex.org/W2109363337","https://openalex.org/W2116079122","https://openalex.org/W2127824649","https://openalex.org/W2128985829","https://openalex.org/W2133199783","https://openalex.org/W2135724221","https://openalex.org/W2138550913","https://openalex.org/W2140785063","https://openalex.org/W2143033696","https://openalex.org/W2143426320","https://openalex.org/W2147246240","https://openalex.org/W2148603752","https://openalex.org/W2159400887","https://openalex.org/W2160450758","https://openalex.org/W2165054897","https://openalex.org/W2611104316"],"related_works":["https://openalex.org/W2943416042","https://openalex.org/W1544923801","https://openalex.org/W3152114242","https://openalex.org/W77579337","https://openalex.org/W2024853484","https://openalex.org/W2086336666","https://openalex.org/W1558015528","https://openalex.org/W1496974872","https://openalex.org/W2408835720","https://openalex.org/W2074092657"],"abstract_inverted_index":{"MOTIVATION:":[0],"Microarray":[1],"gene":[2,130],"expression":[3,131],"data":[4],"are":[5],"increasingly":[6],"employed":[7],"to":[8,29,41,184,193],"identify":[9],"sets":[10],"of":[11,53,73,79,90,103,133,136,160,188],"marker":[12],"genes":[13],"that":[14,140],"accurately":[15],"predict":[16],"disease":[17],"development":[18],"and":[19,83,112,126,147,153,192],"outcome":[20,67,196],"in":[21,158],"cancer.":[22],"Many":[23],"computational":[24,60,104,190],"approaches":[25,191],"have":[26],"been":[27],"proposed":[28],"construct":[30],"such":[31,167],"predictors.":[32],"However,":[33],"there":[34],"is,":[35],"as":[36,168],"yet,":[37],"no":[38,58],"objective":[39,88],"way":[40],"evaluate":[42,185],"whether":[43],"a":[44,80,96,181],"new":[45,189],"approach":[46,61],"truly":[47],"improves":[48],"on":[49,109,128,198],"the":[50,54,77,91,100,161,169,186],"current":[51],"state":[52],"art.":[55],"In":[56],"addition":[57],"'standard'":[59],"has":[62],"emerged":[63],"which":[64,86],"enables":[65],"robust":[66,182],"prediction.":[68],"RESULTS:":[69],"An":[70],"important":[71],"contribution":[72],"this":[74,117],"work":[75,150],"is":[76],"description":[78],"principled":[81],"training":[82],"validation":[84],"protocol,":[85,119],"allows":[87],"evaluation":[89],"complete":[92],"methodology":[93,183],"for":[94],"constructing":[95],"predictor.":[97],"We":[98,138],"review":[99],"possible":[101],"choices":[102],"approaches,":[105],"with":[106],"specific":[107],"emphasis":[108],"predictor":[110],"choice":[111],"reporter":[113,123,142],"selection":[114,124,143],"strategies.":[115],"Employing":[116],"training-validation":[118,178],"we":[120],"evaluated":[121],"different":[122,199],"strategies":[125,144],"predictors":[127],"six":[129,162],"datasets":[132],"varying":[134],"degrees":[135],"difficulty.":[137],"demonstrate":[139],"simple":[141,165],"(forward":[145],"filtering":[146],"shrunken":[148],"centroids)":[149],"surprisingly":[151],"well":[152],"outperform":[154,173],"partial":[155],"least":[156],"squares":[157],"four":[159],"datasets.":[163,200],"Similarly,":[164],"predictors,":[166],"nearest":[170],"mean":[171],"classifier,":[172],"more":[174],"complex":[175],"classifiers.":[176],"Our":[177],"protocol":[179],"provides":[180],"performance":[187],"objectively":[194],"compare":[195],"predictions":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":7}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}