{"id":"https://openalex.org/W2142415307","doi":"https://doi.org/10.1093/bioinformatics/bti270","title":"Use of within-array replicate spots for assessing differential expression in microarray experiments","display_name":"Use of within-array replicate spots for assessing differential expression in microarray experiments","publication_year":2005,"publication_date":"2005-01-18","ids":{"openalex":"https://openalex.org/W2142415307","doi":"https://doi.org/10.1093/bioinformatics/bti270","mag":"2142415307","pmid":"https://pubmed.ncbi.nlm.nih.gov/15657102"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti270","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti270","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/9/2067/48972601/bioinformatics_21_9_2067.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/9/2067/48972601/bioinformatics_21_9_2067.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054704071","display_name":"Gordon K. Smyth","orcid":"https://orcid.org/0000-0001-9221-2892"},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"G. K. Smyth","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia. smyth@wehi.edu.au","Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia"],"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia. smyth@wehi.edu.au","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005700148","display_name":"Jean Michaud","orcid":"https://orcid.org/0000-0003-3883-4484"},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Michaud","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research  Melbourne, Vic 3050, Australia","Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia"],"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research  Melbourne, Vic 3050, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038779121","display_name":"Hamish S. Scott","orcid":"https://orcid.org/0000-0002-5813-631X"},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"H. S. Scott","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research  Melbourne, Vic 3050, Australia","Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia"],"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research  Melbourne, Vic 3050, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic 3050, Australia","institution_ids":["https://openalex.org/I196021976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054704071"],"corresponding_institution_ids":["https://openalex.org/I196021976"],"apc_list":null,"apc_paid":null,"fwci":20.8874,"has_fulltext":false,"cited_by_count":1418,"citation_normalized_percentile":{"value":0.99759908,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"21","issue":"9","first_page":"2067","last_page":"2075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.9020018577575684},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.6822211146354675},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5099042654037476},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.49437975883483887},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.4502989649772644},{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.43021726608276367},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.4273957908153534},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4254770278930664},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4129945635795593},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.41216111183166504},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3712857961654663},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.28447914123535156},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27966153621673584},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.261616587638855},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23604971170425415},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1688632369041443},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16494843363761902},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.15987583994865417}],"concepts":[{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.9020018577575684},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.6822211146354675},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5099042654037476},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.49437975883483887},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.4502989649772644},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.43021726608276367},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.4273957908153534},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4254770278930664},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4129945635795593},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.41216111183166504},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3712857961654663},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28447914123535156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27966153621673584},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.261616587638855},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23604971170425415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1688632369041443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16494843363761902},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15987583994865417},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bti270","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti270","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/9/2067/48972601/bioinformatics_21_9_2067.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15657102","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15657102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.106.5339","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.106.5339","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.statsci.org/smyth/pubs/dupcor.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti270","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti270","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/9/2067/48972601/bioinformatics_21_9_2067.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"},{"score":0.5,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2142415307.pdf","grobid_xml":"https://content.openalex.org/works/W2142415307.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W195212144","https://openalex.org/W1495359568","https://openalex.org/W1506545167","https://openalex.org/W1587094587","https://openalex.org/W1884696523","https://openalex.org/W1976088315","https://openalex.org/W1976625175","https://openalex.org/W1995017987","https://openalex.org/W2002810210","https://openalex.org/W2013444425","https://openalex.org/W2037211381","https://openalex.org/W2067306349","https://openalex.org/W2071650644","https://openalex.org/W2072868135","https://openalex.org/W2074089196","https://openalex.org/W2081098333","https://openalex.org/W2091841926","https://openalex.org/W2094029329","https://openalex.org/W2098104648","https://openalex.org/W2099114361","https://openalex.org/W2102601764","https://openalex.org/W2104143846","https://openalex.org/W2105793531","https://openalex.org/W2110030053","https://openalex.org/W2110153755","https://openalex.org/W2113431091","https://openalex.org/W2113836695","https://openalex.org/W2117607208","https://openalex.org/W2120488121","https://openalex.org/W2126226510","https://openalex.org/W2128694650","https://openalex.org/W2137807839","https://openalex.org/W2143941462","https://openalex.org/W2144227498","https://openalex.org/W2156564301","https://openalex.org/W2157795344","https://openalex.org/W2160697532","https://openalex.org/W2170264612","https://openalex.org/W2497297917","https://openalex.org/W3125904670","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W1536722219","https://openalex.org/W1971329594","https://openalex.org/W2160130936","https://openalex.org/W2061675700","https://openalex.org/W2051808073","https://openalex.org/W2135361361","https://openalex.org/W2013459907","https://openalex.org/W2116343100","https://openalex.org/W2412120523","https://openalex.org/W3154327893"],"abstract_inverted_index":{"The":[0],"methodology":[1],"is":[2],"implemented":[3],"in":[4],"the":[5,13],"limma":[6],"software":[7],"package":[8],"for":[9],"R,":[10],"available":[11],"from":[12],"CRAN":[14],"repository":[15],"http://www.r-project.org":[16]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":50},{"year":2023,"cited_by_count":60},{"year":2022,"cited_by_count":65},{"year":2021,"cited_by_count":62},{"year":2020,"cited_by_count":74},{"year":2019,"cited_by_count":62},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":66},{"year":2016,"cited_by_count":84},{"year":2015,"cited_by_count":98},{"year":2014,"cited_by_count":104},{"year":2013,"cited_by_count":99},{"year":2012,"cited_by_count":85}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}