{"id":"https://openalex.org/W2104580096","doi":"https://doi.org/10.1093/bioinformatics/bti211","title":"TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA","display_name":"TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA","publication_year":2004,"publication_date":"2004-12-14","ids":{"openalex":"https://openalex.org/W2104580096","doi":"https://doi.org/10.1093/bioinformatics/bti211","mag":"2104580096","pmid":"https://pubmed.ncbi.nlm.nih.gov/15598838"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti211","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/8/1401/48972924/bioinformatics_21_8_1401.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/8/1401/48972924/bioinformatics_21_8_1401.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045958734","display_name":"Xiaochen Bo","orcid":"https://orcid.org/0000-0003-1911-7922"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"X. Bo","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850, China","Beijing Institute of Radiation Medicine 27 Taiping Road, Haidian District, Beijing 100850, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Radiation Medicine 27 Taiping Road, Haidian District, Beijing 100850, China#TAB#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032338349","display_name":"Shengjun Wang","orcid":"https://orcid.org/0000-0001-6584-1183"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Wang","raw_affiliation_strings":["Beijing Institute of Radiation Medicine  27 Taiping Road, Haidian District, Beijing 100850, China","Beijing Institute of Radiation Medicine 27 Taiping Road, Haidian District, Beijing 100850, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine  27 Taiping Road, Haidian District, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Radiation Medicine 27 Taiping Road, Haidian District, Beijing 100850, China#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045958734"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3508,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.57796554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"21","issue":"8","first_page":"1401","last_page":"1402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.7031646370887756},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.6272914409637451},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.6099548935890198},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5136070251464844},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4564611315727234},{"id":"https://openalex.org/keywords/mast","display_name":"Mast (botany)","score":0.45376837253570557},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44966262578964233},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3447411060333252},{"id":"https://openalex.org/keywords/mast-cell","display_name":"Mast cell","score":0.2602269649505615},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1763439178466797},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1458035111427307},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.09035339951515198},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.0828520655632019},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.07764893770217896}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7031646370887756},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6272914409637451},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6099548935890198},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5136070251464844},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4564611315727234},{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.45376837253570557},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44966262578964233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3447411060333252},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.2602269649505615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1763439178466797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1458035111427307},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.09035339951515198},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0828520655632019},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07764893770217896}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti211","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/8/1401/48972924/bioinformatics_21_8_1401.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15598838","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15598838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti211","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti211","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/8/1401/48972924/bioinformatics_21_8_1401.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104580096.pdf","grobid_xml":"https://content.openalex.org/works/W2104580096.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1584948423","https://openalex.org/W1964997792","https://openalex.org/W2046220821","https://openalex.org/W2052973382","https://openalex.org/W2087257928","https://openalex.org/W2116009187","https://openalex.org/W2132072016","https://openalex.org/W2141157874","https://openalex.org/W2153838953"],"related_works":["https://openalex.org/W3167662755","https://openalex.org/W2066593496","https://openalex.org/W3113234623","https://openalex.org/W2388471936","https://openalex.org/W2746654039","https://openalex.org/W2057944625","https://openalex.org/W3037594056","https://openalex.org/W2159038264","https://openalex.org/W3194739067","https://openalex.org/W2840367830"],"abstract_inverted_index":{"sqwang@nic.bmi.ac.cn.":[0]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}