{"id":"https://openalex.org/W2123497007","doi":"https://doi.org/10.1093/bioinformatics/bti1102","title":"Predicting post-synaptic activity in proteins with data mining","display_name":"Predicting post-synaptic activity in proteins with data mining","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2123497007","doi":"https://doi.org/10.1093/bioinformatics/bti1102","mag":"2123497007","pmid":"https://pubmed.ncbi.nlm.nih.gov/16204101"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti1102","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti1102","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009911024","display_name":"Gisele L. Pappa","orcid":"https://orcid.org/0000-0002-0349-4494"},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gisele L. Pappa","raw_affiliation_strings":["Computing Laboratory, University of Kent, Canterbury, UK","Computing Laboratory University of Kent Canterbury, CT2 7NF, UK"],"affiliations":[{"raw_affiliation_string":"Computing Laboratory, University of Kent, Canterbury, UK","institution_ids":["https://openalex.org/I20581793"]},{"raw_affiliation_string":"Computing Laboratory University of Kent Canterbury, CT2 7NF, UK","institution_ids":["https://openalex.org/I20581793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022558805","display_name":"Anthony J. Baines","orcid":"https://orcid.org/0000-0003-3068-7811"},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony J. Baines","raw_affiliation_strings":["Department of Biosciences, University of Kent  Canterbury CT2 7NJ, UK"],"affiliations":[{"raw_affiliation_string":"Department of Biosciences, University of Kent  Canterbury CT2 7NJ, UK","institution_ids":["https://openalex.org/I20581793"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087201377","display_name":"Alex A. Freitas","orcid":"https://orcid.org/0000-0001-9825-4700"},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex A. Freitas","raw_affiliation_strings":["Computing Laboratory University of Kent Canterbury, CT2 7NF, UK"],"affiliations":[{"raw_affiliation_string":"Computing Laboratory University of Kent Canterbury, CT2 7NF, UK","institution_ids":["https://openalex.org/I20581793"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009911024"],"corresponding_institution_ids":["https://openalex.org/I20581793"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6302,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67040905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"suppl_2","first_page":"ii19","last_page":"ii25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9747999906539917,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6828321218490601},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.5215725302696228},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4649682343006134},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4416029453277588},{"id":"https://openalex.org/keywords/synaptic-cleft","display_name":"Synaptic cleft","score":0.41335272789001465},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38588598370552063},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36564868688583374},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.12464156746864319},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.09452620148658752}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6828321218490601},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.5215725302696228},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4649682343006134},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4416029453277588},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.41335272789001465},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38588598370552063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36564868688583374},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12464156746864319},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.09452620148658752},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bti1102","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti1102","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16204101","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16204101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:kar.kent.ac.uk:14254","is_oa":false,"landing_page_url":"https://kar.kent.ac.uk/14254/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1500368251","https://openalex.org/W1505791519","https://openalex.org/W1523293200","https://openalex.org/W1570448133","https://openalex.org/W1590746293","https://openalex.org/W2086301041","https://openalex.org/W2100069291","https://openalex.org/W2106791925","https://openalex.org/W2118892942","https://openalex.org/W2123858481","https://openalex.org/W2126975650","https://openalex.org/W2140190241","https://openalex.org/W2141262207","https://openalex.org/W2156630822","https://openalex.org/W2160521949","https://openalex.org/W2797114046","https://openalex.org/W3084324055"],"related_works":["https://openalex.org/W1630076647","https://openalex.org/W2371138613","https://openalex.org/W2080152487","https://openalex.org/W2048963458","https://openalex.org/W43109613","https://openalex.org/W2359952343","https://openalex.org/W2922249299","https://openalex.org/W2239445980","https://openalex.org/W2120455979","https://openalex.org/W1992324151"],"abstract_inverted_index":{"The":[0,85,140],"bioinformatics":[1],"problem":[2,20],"being":[3],"addressed":[4],"in":[5,64,82,101,111],"this":[6,119],"paper":[7],"is":[8,21,87],"to":[9,88,125,147,156,159],"predict":[10,131],"whether":[11,132],"or":[12,133],"not":[13,134],"a":[14,57,83,135],"protein":[15,136],"has":[16,137],"post-synaptic":[17,29,43,104,114,138],"activity.":[18,139],"This":[19],"of":[22,35,60,92,96,164],"great":[23],"intrinsic":[24],"interest":[25],"because":[26],"proteins":[27,41,61,78,97,102,112],"with":[28,33,62,103,145,154],"activities":[30],"are":[31],"connected":[32],"functioning":[34],"the":[36,93,162],"nervous":[37],"system.":[38],"Indeed,":[39],"many":[40],"having":[42],"activity":[44,105],"have":[45],"been":[46],"functionally":[47],"characterized":[48],"by":[49],"biochemical,":[50],"immunological":[51],"and":[52,68,76,116,153],"proteomic":[53],"exercises.":[54],"They":[55],"represent":[56],"wide":[58],"variety":[59],"functions":[63],"extracellular":[65],"signal":[66],"reception":[67],"propagation":[69],"through":[70],"intracellular":[71],"apparatuses,":[72],"cell":[73],"adhesion":[74],"molecules":[75],"scaffolding":[77],"that":[79,98,130],"link":[80],"them":[81],"web.":[84],"challenge":[86],"automatically":[89,126],"discover":[90,127],"features":[91],"primary":[94],"sequences":[95],"typically":[99],"occur":[100,110],"but":[106],"rarely":[107],"(or":[108],"never)":[109],"without":[113],"activity,":[115],"vice-versa.":[117],"In":[118],"context,":[120],"we":[121],"used":[122],"data":[123],"mining":[124],"classification":[128],"rules":[129,142],"discovered":[141],"were":[143],"analysed":[144],"respect":[146,155],"their":[148,157],"predictive":[149],"accuracy":[150],"(generalization":[151],"ability)":[152],"interestingness":[158],"biologists":[160],"(in":[161],"sense":[163],"representing":[165],"novel,":[166],"unexpected":[167],"knowledge).":[168]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
