{"id":"https://openalex.org/W2161634498","doi":"https://doi.org/10.1093/bioinformatics/bti1100","title":"Augmented cell-graphs for automated cancer diagnosis","display_name":"Augmented cell-graphs for automated cancer diagnosis","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2161634498","doi":"https://doi.org/10.1093/bioinformatics/bti1100","mag":"2161634498","pmid":"https://pubmed.ncbi.nlm.nih.gov/16204128"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti1100","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/suppl_2/ii7/52089752/bioinformatics_21_suppl2_ii7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/suppl_2/ii7/52089752/bioinformatics_21_suppl2_ii7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002335701","display_name":"Cigdem Demir","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cigdem Demir","raw_affiliation_strings":["Department of Computer Science, Rensselaer Polytechnic Institute Troy, NY 12180, USA. demir@cs.rpi.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Rensselaer Polytechnic Institute Troy, NY 12180, USA. demir@cs.rpi.edu","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057806366","display_name":"Sakir H. Gultekin","orcid":"https://orcid.org/0000-0002-4717-0408"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Humayun Gultekin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073676361","display_name":"B\u00fclent Yener","orcid":"https://orcid.org/0000-0003-3989-6097"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00fclent Yener","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002335701"],"corresponding_institution_ids":["https://openalex.org/I165799507"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.2141,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91349216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"21","issue":"suppl_2","first_page":"ii7","last_page":"ii12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnification","display_name":"Magnification","score":0.6668040752410889},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5437530279159546},{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.5019750595092773},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.48149120807647705},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4305069148540497},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.393806129693985},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36088883876800537},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3568333387374878},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2989896535873413},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.27000099420547485},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.1018659770488739},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08076578378677368}],"concepts":[{"id":"https://openalex.org/C4144372","wikidata":"https://www.wikidata.org/wiki/Q675287","display_name":"Magnification","level":2,"score":0.6668040752410889},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5437530279159546},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5019750595092773},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.48149120807647705},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4305069148540497},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.393806129693985},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36088883876800537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3568333387374878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2989896535873413},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.27000099420547485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1018659770488739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08076578378677368}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bti1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti1100","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/suppl_2/ii7/52089752/bioinformatics_21_suppl2_ii7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16204128","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16204128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.332.6771","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.6771","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.rpi.edu/~yener/PAPERS/BIO/eccb.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti1100","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/suppl_2/ii7/52089752/bioinformatics_21_suppl2_ii7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161634498.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1554663460","https://openalex.org/W1976969221","https://openalex.org/W1990478471","https://openalex.org/W2007147765","https://openalex.org/W2027123781","https://openalex.org/W2057343036","https://openalex.org/W2059432853","https://openalex.org/W2065281378","https://openalex.org/W2067622074","https://openalex.org/W2084705412","https://openalex.org/W2094786692","https://openalex.org/W2111324774","https://openalex.org/W2112737775","https://openalex.org/W2126409447","https://openalex.org/W2126563020","https://openalex.org/W2132048066","https://openalex.org/W2134772683","https://openalex.org/W2144012133","https://openalex.org/W2144349513","https://openalex.org/W2150430828","https://openalex.org/W2153547712","https://openalex.org/W2406134447","https://openalex.org/W2996555727"],"related_works":["https://openalex.org/W4256609757","https://openalex.org/W2152595177","https://openalex.org/W2041117173","https://openalex.org/W2022127494","https://openalex.org/W1810141276","https://openalex.org/W1977757029","https://openalex.org/W2005715326","https://openalex.org/W2418534670","https://openalex.org/W2047186806","https://openalex.org/W2171082272"],"abstract_inverted_index":{"This":[0],"work":[1],"reports":[2],"a":[3,31,40,43,50,55,90],"novel":[4],"computational":[5],"method":[6],"based":[7],"on":[8,89],"augmented":[9],"cell-graphs":[10],"(ACG),":[11],"which":[12,39],"are":[13,69,87],"constructed":[14],"from":[15,101],"low-magnification":[16],"tissue":[17,130],"images":[18],"for":[19],"the":[20,61,64,77,80,85,109,123,129],"mathematical":[21],"diagnosis":[22],"of":[23,52,66,79,95,114,118],"brain":[24,98],"cancer":[25],"(malignant":[26],"glioma).":[27],"An":[28],"ACG":[29,68,110],"is":[30,93,106],"simple,":[32],"undirected,":[33],"weighted":[34],"and":[35,46,63,116,120,125],"complete":[36],"graph":[37],"in":[38,132],"node":[41],"represents":[42],"cell":[44],"cluster":[45],"an":[47,67],"edge":[48],"between":[49,58],"pair":[51],"nodes":[53,62],"defines":[54],"binary":[56],"relationship":[57],"them.":[59],"Both":[60],"edges":[65],"assigned":[70],"weights":[71],"to":[72],"capture":[73],"more":[74],"information":[75],"about":[76],"topology":[78],"tissue.":[81],"In":[82],"this":[83],"work,":[84],"experiments":[86],"conducted":[88],"dataset":[91],"that":[92,108],"comprised":[94],"646":[96],"human":[97],"biopsy":[99],"samples":[100],"60":[102],"different":[103],"patients.":[104],"It":[105],"shown":[107],"approach":[111],"yields":[112],"sensitivity":[113],"97.53%":[115],"specificities":[117],"93.33":[119],"98.15%":[121],"(for":[122],"inflamed":[124],"healthy,":[126],"respectively)":[127],"at":[128],"level":[131],"glioma":[133],"diagnosis.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}