{"id":"https://openalex.org/W2149184178","doi":"https://doi.org/10.1093/bioinformatics/bth914","title":"Mining MEDLINE for implicit links between dietary substances and diseases","display_name":"Mining MEDLINE for implicit links between dietary substances and diseases","publication_year":2004,"publication_date":"2004-07-19","ids":{"openalex":"https://openalex.org/W2149184178","doi":"https://doi.org/10.1093/bioinformatics/bth914","mag":"2149184178","pmid":"https://pubmed.ncbi.nlm.nih.gov/15262811"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bth914","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth914","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016839456","display_name":"Padmini Srinivasan","orcid":"https://orcid.org/0000-0001-8791-403X"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Padmini Srinivasan","raw_affiliation_strings":["School of Library and Information Science, University of Iowa, Iowa City, IA 52242, USA. padmini-srinivasan@uiowa.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Library and Information Science, University of Iowa, Iowa City, IA 52242, USA. padmini-srinivasan@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011309581","display_name":"Bisharah Libbus","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bisharah Libbus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016839456"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.4306,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.95382016,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"suppl_1","first_page":"i290","last_page":"i296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.5770000219345093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.5770000219345093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"Curcumin","score":0.6619279980659485},{"id":"https://openalex.org/keywords/curcuma","display_name":"Curcuma","score":0.6129782199859619},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.59370356798172},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5335716605186462},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.45624297857284546},{"id":"https://openalex.org/keywords/knowledge-extraction","display_name":"Knowledge extraction","score":0.4557918310165405},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.45089367032051086},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4233967959880829},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33366668224334717},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2899172008037567},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2878587245941162},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1868436336517334},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.16454428434371948},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.1360449492931366},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.12105083465576172}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.6619279980659485},{"id":"https://openalex.org/C2777230291","wikidata":"https://www.wikidata.org/wiki/Q33551","display_name":"Curcuma","level":2,"score":0.6129782199859619},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.59370356798172},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5335716605186462},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.45624297857284546},{"id":"https://openalex.org/C120567893","wikidata":"https://www.wikidata.org/wiki/Q1582085","display_name":"Knowledge extraction","level":2,"score":0.4557918310165405},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.45089367032051086},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4233967959880829},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33366668224334717},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2899172008037567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2878587245941162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1868436336517334},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16454428434371948},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.1360449492931366},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12105083465576172}],"mesh":[{"descriptor_ui":"D000043","descriptor_name":"Abstracting and Indexing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000043","descriptor_name":"Abstracting and Indexing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000043","descriptor_name":"Abstracting and Indexing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004035","descriptor_name":"Diet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004035","descriptor_name":"Diet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004035","descriptor_name":"Diet Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D013118","descriptor_name":"Spinal Cord Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D013118","descriptor_name":"Spinal Cord Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D013118","descriptor_name":"Spinal Cord Diseases","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bth914","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth914","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15262811","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15262811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.10.3525","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.10.3525","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mingo.info-science.uiowa.edu/padmini/TurmericBio.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1553011358","https://openalex.org/W1562176487","https://openalex.org/W2011726136","https://openalex.org/W2015954361","https://openalex.org/W2038316408","https://openalex.org/W2067096102","https://openalex.org/W2087035995","https://openalex.org/W2089177530","https://openalex.org/W2097352796","https://openalex.org/W2105562985","https://openalex.org/W2115159360","https://openalex.org/W2141243410","https://openalex.org/W2142063400"],"related_works":["https://openalex.org/W3043313011","https://openalex.org/W2079207441","https://openalex.org/W2555437012","https://openalex.org/W3014268340","https://openalex.org/W2188985411","https://openalex.org/W2789343877","https://openalex.org/W4304688893","https://openalex.org/W4360990708","https://openalex.org/W4200122190","https://openalex.org/W2417212756"],"abstract_inverted_index":{"MOTIVATION:":[0],"Text":[1],"mining":[2,16,148],"systems":[3],"aim":[4],"at":[5],"knowledge":[6],"discovery":[7,130],"from":[8],"text":[9,15,147],"collections.":[10],"This":[11,125],"work":[12],"presents":[13],"our":[14,129,146],"algorithm":[17,131,149],"and":[18,80,123,141],"demonstrates":[19],"its":[20,53],"use":[21,36],"to":[22,38,83,135,153],"uncover":[23,154],"information":[24,155],"that":[25,63,90,128,156],"could":[26],"form":[27],"the":[28,84],"basis":[29],"of":[30,97,165],"new":[31,159],"hypotheses.":[32],"In":[33],"particular,":[34],"we":[35],"it":[37],"discover":[39],"novel":[40,65,137],"uses":[41,138],"for":[42,52,68,101,139],"Curcuma":[43],"longa,":[44],"a":[45,98,162],"dietary":[46,140],"substance,":[47],"which":[48],"is":[49,92,108],"highly":[50],"regarded":[51],"therapeutic":[54],"properties":[55],"in":[56,95,103],"Asia.":[57],"RESULTS:":[58],"Several":[59],"disease":[60,79],"were":[61],"identified":[62],"offer":[64],"research":[66,126],"contexts":[67],"curcumin.":[69],"We":[70],"analyze":[71],"select":[72],"suggestions,":[73],"such":[74,116],"as":[75,117],"retinal":[76],"diseases,":[77],"Crohn's":[78],"disorders":[81],"related":[82],"spinal":[85],"cord.":[86],"Our":[87],"analysis":[88],"suggests":[89,127],"there":[91],"strong":[93],"evidence":[94,107],"favor":[96],"beneficial":[99],"role":[100],"curcumin":[102],"these":[104],"diseases.":[105],"The":[106],"based":[109],"on":[110,113,161],"curcumin's":[111],"influence":[112],"several":[114],"genes,":[115],"COX-2,":[118],"TNF-alpha,":[119],"JNK,":[120],"p38":[121],"MAPK":[122],"TGF-beta.":[124],"may":[132,150],"be":[133,151],"used":[134,152],"suggest":[136],"pharmacological":[142],"substances.":[143],"More":[144],"generally,":[145],"potentially":[157],"sheds":[158],"light":[160],"given":[163],"topic":[164],"interest.":[166],"AVAILABILITY:":[167],"Contact":[168],"authors.":[169]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}