{"id":"https://openalex.org/W2111602998","doi":"https://doi.org/10.1093/bioinformatics/bth412","title":"An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites","display_name":"An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2111602998","doi":"https://doi.org/10.1093/bioinformatics/bth412","mag":"2111602998","pmid":"https://pubmed.ncbi.nlm.nih.gov/15256408"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bth412","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth412","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/18/3387/48906525/bioinformatics_20_18_3387.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/20/18/3387/48906525/bioinformatics_20_18_3387.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009596579","display_name":"Vitaly A. Selivanov","orcid":"https://orcid.org/0000-0002-7937-9249"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vitaly A. Selivanov","raw_affiliation_strings":["Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain","Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain","institution_ids":[]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057704800","display_name":"Joaquim Puigjaner","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joaquim Puigjaner","raw_affiliation_strings":["Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105937221","display_name":"Antonio Sillero","orcid":null},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Sillero","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Instituto de Investigaciones Biom\u00e9dicas, Alberto Sols UAM/CSIC, Facultad de Medicina, Arzobispo Morcillo 4, 28029 Madrid, Spain#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Instituto de Investigaciones Biom\u00e9dicas, Alberto Sols UAM/CSIC, Facultad de Medicina, Arzobispo Morcillo 4, 28029 Madrid, Spain#TAB#","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088356514","display_name":"Josep J. Centelles","orcid":"https://orcid.org/0000-0002-6289-9678"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josep J. Centelles","raw_affiliation_strings":["Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662322","display_name":"Antonio Ramos\u2010Montoya","orcid":"https://orcid.org/0000-0001-7573-4066"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Ramos-Montoya","raw_affiliation_strings":["Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062483693","display_name":"Paul W. N. Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]},{"id":"https://openalex.org/I2801403999","display_name":"UCLA Medical Center","ror":"https://ror.org/04vq5kb54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I2801403999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W.-N. Lee","raw_affiliation_strings":["Department of Pediatrics, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA 90502, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA 90502, USA#TAB#","institution_ids":["https://openalex.org/I2801403999","https://openalex.org/I4210165985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089973047","display_name":"Marta Cascante","orcid":"https://orcid.org/0000-0002-2062-4633"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Cascante","raw_affiliation_strings":["Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#"],"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica i Biologia Molecular, Facultat de Qu\u00edmica and CERQT at Parc Cient\u00edfic de Barcelona, Barcelona, Catalunya, Spain,#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009596579"],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.2864,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.78084232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"18","first_page":"3387","last_page":"3397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotopomers","display_name":"Isotopomers","score":0.7176364660263062},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.5898218154907227},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5491873025894165},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5425028204917908},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.4962642788887024},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4892578125},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2826370298862457},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25714683532714844},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07400396466255188}],"concepts":[{"id":"https://openalex.org/C127124265","wikidata":"https://www.wikidata.org/wiki/Q2100870","display_name":"Isotopomers","level":3,"score":0.7176364660263062},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5898218154907227},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5491873025894165},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5425028204917908},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4962642788887024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4892578125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2826370298862457},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25714683532714844},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07400396466255188},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bth412","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth412","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/18/3387/48906525/bioinformatics_20_18_3387.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15256408","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15256408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bth412","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth412","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/18/3387/48906525/bioinformatics_20_18_3387.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111602998.pdf","grobid_xml":"https://content.openalex.org/works/W2111602998.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W79437885","https://openalex.org/W125579703","https://openalex.org/W1479810458","https://openalex.org/W1480936801","https://openalex.org/W1484331337","https://openalex.org/W1485030470","https://openalex.org/W1493787054","https://openalex.org/W1504411129","https://openalex.org/W1526467696","https://openalex.org/W1549580994","https://openalex.org/W1567530835","https://openalex.org/W1573822398","https://openalex.org/W1889077695","https://openalex.org/W1985591464","https://openalex.org/W2003169371","https://openalex.org/W2012159845","https://openalex.org/W2019234198","https://openalex.org/W2053942984","https://openalex.org/W2064144364","https://openalex.org/W2075431945","https://openalex.org/W2096767559","https://openalex.org/W2136811206","https://openalex.org/W2138520475","https://openalex.org/W2321274769","https://openalex.org/W2417352139","https://openalex.org/W2460823957"],"related_works":["https://openalex.org/W1965853711","https://openalex.org/W2159251141","https://openalex.org/W2056963518","https://openalex.org/W1978212487","https://openalex.org/W2133525758","https://openalex.org/W2952703217","https://openalex.org/W2005759880","https://openalex.org/W1008874353","https://openalex.org/W2082562869","https://openalex.org/W2006196154"],"abstract_inverted_index":{"The":[0],"software":[1],"could":[2],"be":[3],"freely":[4],"downloaded":[5],"from":[6],"the":[7],"site:":[8],"http://bq.ub.es/bioqint/label_distribution/.":[9]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}