{"id":"https://openalex.org/W2152327613","doi":"https://doi.org/10.1093/bioinformatics/bth374","title":"Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences","display_name":"Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences","publication_year":2004,"publication_date":"2004-06-23","ids":{"openalex":"https://openalex.org/W2152327613","doi":"https://doi.org/10.1093/bioinformatics/bth374","mag":"2152327613","pmid":"https://pubmed.ncbi.nlm.nih.gov/15217813"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bth374","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth374","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031779274","display_name":"\u00c9ric Bonnet","orcid":"https://orcid.org/0000-0002-8468-2867"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Bonnet","raw_affiliation_strings":["Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium","Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046780819","display_name":"J. Wuyts","orcid":null},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Wuyts","raw_affiliation_strings":["Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114065180","display_name":"Pierre Rouz\u00e9","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Rouz\u00e9","raw_affiliation_strings":["Laboratoire associ\u00e9 de l'INRA, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire associ\u00e9 de l'INRA, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070738091","display_name":"Yves Van de Peer","orcid":"https://orcid.org/0000-0003-4327-3730"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Yves Van de Peer","raw_affiliation_strings":["Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium and","institution_ids":["https://openalex.org/I32597200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070738091"],"corresponding_institution_ids":["https://openalex.org/I32597200"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":8.9549,"has_fulltext":false,"cited_by_count":563,"citation_normalized_percentile":{"value":0.98774162,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":"17","first_page":"2911","last_page":"2917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.751800000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.751800000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-secondary-structure","display_name":"Nucleic acid secondary structure","score":0.6922510266304016},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6300409436225891},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.6128211617469788},{"id":"https://openalex.org/keywords/ribosomal-rna","display_name":"Ribosomal RNA","score":0.5768657922744751},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.566868007183075},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5246753096580505},{"id":"https://openalex.org/keywords/shuffling","display_name":"Shuffling","score":0.5098175406455994},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.5065776109695435},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.46998465061187744},{"id":"https://openalex.org/keywords/small-nucleolar-rna","display_name":"Small nucleolar RNA","score":0.4687614142894745},{"id":"https://openalex.org/keywords/nucleic-acid-structure","display_name":"Nucleic acid structure","score":0.46180006861686707},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36966902017593384},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34540989995002747},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.3210468292236328},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.133571058511734},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0800255537033081}],"concepts":[{"id":"https://openalex.org/C85468374","wikidata":"https://www.wikidata.org/wiki/Q6589957","display_name":"Nucleic acid secondary structure","level":4,"score":0.6922510266304016},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6300409436225891},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.6128211617469788},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5768657922744751},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.566868007183075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5246753096580505},{"id":"https://openalex.org/C167927819","wikidata":"https://www.wikidata.org/wiki/Q1930567","display_name":"Shuffling","level":2,"score":0.5098175406455994},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5065776109695435},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.46998465061187744},{"id":"https://openalex.org/C179255354","wikidata":"https://www.wikidata.org/wiki/Q284416","display_name":"Small nucleolar RNA","level":5,"score":0.4687614142894745},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.46180006861686707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36966902017593384},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34540989995002747},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.3210468292236328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.133571058511734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0800255537033081},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bth374","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth374","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15217813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15217813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:archive.ugent.be:298757","is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/298757","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1367-4803","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1542426682","https://openalex.org/W1543796220","https://openalex.org/W1920303762","https://openalex.org/W1967517087","https://openalex.org/W1967760135","https://openalex.org/W1967873557","https://openalex.org/W1977373364","https://openalex.org/W1977940795","https://openalex.org/W1978242636","https://openalex.org/W1980269624","https://openalex.org/W1992501118","https://openalex.org/W1992941735","https://openalex.org/W1998743995","https://openalex.org/W2018550609","https://openalex.org/W2025763720","https://openalex.org/W2044131517","https://openalex.org/W2050256969","https://openalex.org/W2061266715","https://openalex.org/W2061981209","https://openalex.org/W2077055994","https://openalex.org/W2088938573","https://openalex.org/W2100167293","https://openalex.org/W2104465908","https://openalex.org/W2105226315","https://openalex.org/W2116520841","https://openalex.org/W2122575917","https://openalex.org/W2123079914","https://openalex.org/W2125660797","https://openalex.org/W2129137649","https://openalex.org/W2131118100","https://openalex.org/W2131157469","https://openalex.org/W2131674459","https://openalex.org/W2134995632","https://openalex.org/W2135314242","https://openalex.org/W2137257434","https://openalex.org/W2138664009","https://openalex.org/W2140446903","https://openalex.org/W2146642335","https://openalex.org/W2149429041","https://openalex.org/W2150770935","https://openalex.org/W2151922790","https://openalex.org/W2158381555","https://openalex.org/W2167557255","https://openalex.org/W2612575796","https://openalex.org/W3146552763","https://openalex.org/W3214380909","https://openalex.org/W4245668478","https://openalex.org/W4250052351","https://openalex.org/W4292520068"],"related_works":["https://openalex.org/W3047450301","https://openalex.org/W2558432341","https://openalex.org/W1975806245","https://openalex.org/W2345156963","https://openalex.org/W1971402940","https://openalex.org/W2919479895","https://openalex.org/W4318218930","https://openalex.org/W2057388609","https://openalex.org/W2159621058","https://openalex.org/W2412575231"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Most":[2],"non-coding":[3,29],"RNAs":[4,37,40,81],"are":[5,47,145],"characterized":[6],"by":[7,49],"a":[8,50,93,107,114],"specific":[9],"secondary":[10,26,116],"and":[11,38,82,141],"tertiary":[12],"structure":[13,27],"that":[14,97,102],"determines":[15],"their":[16],"function.":[17],"Here,":[18],"we":[19],"investigate":[20],"the":[21,25,55,73,85,88,111,126,129],"folding":[22,61,94],"energy":[23,59,96],"of":[24,28,60,87,121,128,131],"RNA":[30],"sequences,":[31,105],"such":[32],"as":[33,148],"microRNA":[34,89],"precursors,":[35],"transfer":[36,80],"ribosomal":[39,83],"in":[41,53,110,125],"several":[42],"eukaryotic":[43],"taxa.":[44],"Statistical":[45],"biases":[46],"assessed":[48],"randomization":[51],"test,":[52],"which":[54],"predicted":[56],"minimum":[57],"free":[58,95],"is":[62,98,135],"compared":[63],"with":[64,79],"values":[65],"obtained":[66],"for":[67,103],"structures":[68],"inferred":[69],"from":[70],"randomly":[71],"shuffling":[72],"original":[74],"sequences.":[75],"Results:":[76],"In":[77],"contrast":[78],"RNAs,":[84],"majority":[86],"sequences":[90,134],"clearly":[91],"exhibit":[92],"considerably":[99],"lower":[100],"than":[101],"shuffled":[104],"indicating":[106],"high":[108],"tendency":[109],"sequence":[112],"towards":[113],"stable":[115],"structure.":[117],"A":[118],"possible":[119],"usage":[120],"this":[122],"statistical":[123],"test":[124],"framework":[127],"detection":[130],"genuine":[132],"miRNA":[133],"discussed.":[136],"Availability:":[137],"The":[138],"dataset,":[139],"software":[140],"additional":[142],"data":[143],"files":[144],"freely":[146],"available":[147],"supplementary":[149],"information":[150],"on":[151],"our":[152],"Website.":[153],"Supplementary":[154],"information:":[155],"http://www.psb.ugent.be/bioinformatics/":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":39},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":28}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}