{"id":"https://openalex.org/W2145781320","doi":"https://doi.org/10.1093/bioinformatics/bth363","title":"BioSilico: an integrated metabolic database system","display_name":"BioSilico: an integrated metabolic database system","publication_year":2004,"publication_date":"2004-06-17","ids":{"openalex":"https://openalex.org/W2145781320","doi":"https://doi.org/10.1093/bioinformatics/bth363","mag":"2145781320","pmid":"https://pubmed.ncbi.nlm.nih.gov/15201189"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bth363","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth363","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/17/3270/48906515/bioinformatics_20_17_3270.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/20/17/3270/48906515/bioinformatics_20_17_3270.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019937419","display_name":"Bo Kyeng Hou","orcid":"https://orcid.org/0000-0002-9324-5263"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bo Kyeng Hou","raw_affiliation_strings":["Department of BioSystems and Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea","Department of BioSystems and Bioinformatics Research Center#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of BioSystems and Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of BioSystems and Bioinformatics Research Center#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044463050","display_name":"Jin Sik Kim","orcid":"https://orcid.org/0000-0002-4618-4410"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Sik Kim","raw_affiliation_strings":["Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Korea Advanced Institute of Scienc "],"affiliations":[{"raw_affiliation_string":"Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center, Korea Advanced Institute of Scienc ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085585372","display_name":"Ji Hoon Jun","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji Hoon Jun","raw_affiliation_strings":["IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011206845","display_name":"Dong\u2010Yup Lee","orcid":"https://orcid.org/0000-0003-0901-708X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong-Yup Lee","raw_affiliation_strings":["Department of BioSystems and Bioinformatics Research Center#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of BioSystems and Bioinformatics Research Center#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101968025","display_name":"Yong Wook Kim","orcid":"https://orcid.org/0000-0002-5234-2454"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Wook Kim","raw_affiliation_strings":["IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014830754","display_name":"Sujin Chae","orcid":"https://orcid.org/0000-0002-9327-4566"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sujin Chae","raw_affiliation_strings":["Department of Biological Chemistry, College of Pharmacy, Seoul National University, San 56-1 Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, College of Pharmacy, Seoul National University, San 56-1 Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061297233","display_name":"Mira Roh","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mira Roh","raw_affiliation_strings":["IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113749982","display_name":"Yong-Ho In","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Ho In","raw_affiliation_strings":["IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"IDRTech Inc., C-2711, Kolontripolis 1 210, Kumgok-dong, Bundang-gu, Sungnam 463-805, Republic of Korea#TAB#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100616675","display_name":"Sang Yup Lee","orcid":"https://orcid.org/0000-0003-0599-3091"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Yup Lee","raw_affiliation_strings":["Department of BioSystems and Bioinformatics Research Center#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of BioSystems and Bioinformatics Research Center#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5019937419"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.8186,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.70259946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"17","first_page":"3270","last_page":"3272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9815000295639038,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6169437170028687},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4844191372394562}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6169437170028687},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4844191372394562}],"mesh":[{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bth363","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth363","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/17/3270/48906515/bioinformatics_20_17_3270.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15201189","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15201189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bth363","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bth363","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/17/3270/48906515/bioinformatics_20_17_3270.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145781320.pdf","grobid_xml":"https://content.openalex.org/works/W2145781320.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2063007776","https://openalex.org/W2138027806","https://openalex.org/W2164649389","https://openalex.org/W2916406266"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"BioSilico":[0,57],"is":[1,58],"a":[2,27,65],"web-based":[3],"database":[4],"system":[5,63],"that":[6],"facilitates":[7],"the":[8,36],"search":[9],"and":[10,22,43],"analysis":[11],"of":[12],"metabolic":[13,16],"pathways.":[14],"Heterogeneous":[15],"databases":[17],"including":[18],"LIGAND,":[19],"ENZYME,":[20],"EcoCyc":[21],"MetaCyc":[23],"are":[24],"integrated":[25],"in":[26],"systematic":[28,67],"way,":[29],"thereby":[30],"allowing":[31],"users":[32],"to":[33],"efficiently":[34],"retrieve":[35],"relevant":[37],"information":[38],"on":[39],"enzymes,":[40],"biochemical":[41],"compounds":[42],"reactions.":[44],"In":[45],"addition,":[46],"it":[47],"provides":[48],"well-designed":[49],"view":[50],"pages":[51],"for":[52],"more":[53],"detailed":[54],"summary":[55],"information.":[56],"developed":[59],"as":[60],"an":[61],"extensible":[62],"with":[64],"robust":[66],"architecture.":[68]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}