{"id":"https://openalex.org/W2165801360","doi":"https://doi.org/10.1093/bioinformatics/btg477","title":"Bio-support vector machines for computational proteomics","display_name":"Bio-support vector machines for computational proteomics","publication_year":2004,"publication_date":"2004-01-29","ids":{"openalex":"https://openalex.org/W2165801360","doi":"https://doi.org/10.1093/bioinformatics/btg477","mag":"2165801360","pmid":"https://pubmed.ncbi.nlm.nih.gov/14751989"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg477","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg477","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/5/735/48905540/bioinformatics_20_5_735.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/20/5/735/48905540/bioinformatics_20_5_735.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101837304","display_name":"Zheng Rong Yang","orcid":"https://orcid.org/0000-0002-6733-7893"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zheng Rong Yang","raw_affiliation_strings":["Department of Computer Science, Exeter University, Exeter EX4 4PT, UK. Z.R.Yang@exeter.ac.uk","Department of Computer Science, Exeter University, Exeter EX4 4PT, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Exeter University, Exeter EX4 4PT, UK. Z.R.Yang@exeter.ac.uk","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Department of Computer Science, Exeter University, Exeter EX4 4PT, UK,","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113500576","display_name":"Kuo\u2010Chen Chou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098239","display_name":"The Gordon Life Science Institute","ror":"https://ror.org/0135ffj82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098239"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuo-Chen Chou","raw_affiliation_strings":["Gordon Life Science Institute, 13784 Torrey Del Mar Drive, San Diego, CA 92130, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Life Science Institute, 13784 Torrey Del Mar Drive, San Diego, CA 92130, USA#TAB#","institution_ids":["https://openalex.org/I4210098239"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101837304"],"corresponding_institution_ids":["https://openalex.org/I23923803"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.9796,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.94513673,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"5","first_page":"735","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9132000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9132000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.821661651134491},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6482847929000854},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5783842206001282},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5780602097511292},{"id":"https://openalex.org/keywords/computational-complexity-theory","display_name":"Computational complexity theory","score":0.502422571182251},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.48729050159454346},{"id":"https://openalex.org/keywords/relevance-vector-machine","display_name":"Relevance vector machine","score":0.4639527201652527},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.45702242851257324},{"id":"https://openalex.org/keywords/feature-vector","display_name":"Feature vector","score":0.44207894802093506},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.43041059374809265},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.41232842206954956},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.30048373341560364},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14662432670593262}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.821661651134491},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6482847929000854},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5783842206001282},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5780602097511292},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.502422571182251},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48729050159454346},{"id":"https://openalex.org/C14948415","wikidata":"https://www.wikidata.org/wiki/Q7310972","display_name":"Relevance vector machine","level":3,"score":0.4639527201652527},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.45702242851257324},{"id":"https://openalex.org/C83665646","wikidata":"https://www.wikidata.org/wiki/Q42139305","display_name":"Feature vector","level":2,"score":0.44207894802093506},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.43041059374809265},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.41232842206954956},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.30048373341560364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14662432670593262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btg477","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg477","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/5/735/48905540/bioinformatics_20_5_735.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:14751989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14751989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.331.5941","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.331.5941","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/20/5/735.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btg477","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg477","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/5/735/48905540/bioinformatics_20_5_735.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W149741886","https://openalex.org/W195150910","https://openalex.org/W1485790693","https://openalex.org/W1514209943","https://openalex.org/W1576520375","https://openalex.org/W1966952510","https://openalex.org/W1967501922","https://openalex.org/W1968114652","https://openalex.org/W1968873679","https://openalex.org/W1974224443","https://openalex.org/W1977282539","https://openalex.org/W1981555301","https://openalex.org/W1987713050","https://openalex.org/W1990376815","https://openalex.org/W1992577925","https://openalex.org/W1995396220","https://openalex.org/W2006327082","https://openalex.org/W2008767404","https://openalex.org/W2008895011","https://openalex.org/W2008928574","https://openalex.org/W2013704461","https://openalex.org/W2014875362","https://openalex.org/W2015692100","https://openalex.org/W2023779075","https://openalex.org/W2027844353","https://openalex.org/W2030636556","https://openalex.org/W2045722009","https://openalex.org/W2053702224","https://openalex.org/W2054342685","https://openalex.org/W2055522016","https://openalex.org/W2060740730","https://openalex.org/W2070411414","https://openalex.org/W2076747662","https://openalex.org/W2080786231","https://openalex.org/W2084387914","https://openalex.org/W2085318243","https://openalex.org/W2087876594","https://openalex.org/W2098556826","https://openalex.org/W2102354653","https://openalex.org/W2102794349","https://openalex.org/W2110413117","https://openalex.org/W2113398700","https://openalex.org/W2119283514","https://openalex.org/W2119423166","https://openalex.org/W2120026469","https://openalex.org/W2122642866","https://openalex.org/W2122945697","https://openalex.org/W2140926534","https://openalex.org/W2143244636","https://openalex.org/W2145084154","https://openalex.org/W2149528591","https://openalex.org/W2156798505","https://openalex.org/W2156909104","https://openalex.org/W2158338599","https://openalex.org/W2158461363","https://openalex.org/W2165732545","https://openalex.org/W3017143921","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2066952721","https://openalex.org/W2565312173","https://openalex.org/W2335152656","https://openalex.org/W3147035969","https://openalex.org/W2359936972","https://openalex.org/W2383027800","https://openalex.org/W2206547991","https://openalex.org/W2104936869","https://openalex.org/W2186666570","https://openalex.org/W4322737621"],"abstract_inverted_index":{"MOTIVATION:":[0],"One":[1],"of":[2,21,24,43,46,102,120,149],"the":[3,17,32,41,44,47,54,77,86,137,147,154,164,169],"most":[4,62,78],"important":[5],"issues":[6],"in":[7,73,162],"computational":[8,92],"proteomics":[9],"is":[10,51],"to":[11,30,40,69,90,136,146],"produce":[12],"a":[13,117,159],"prediction":[14,33,148],"model":[15,165,170],"for":[16,52,124,129],"classification":[18],"or":[19],"annotation":[20],"biological":[22],"function":[23],"novel":[25],"protein":[26,74,126],"sequences.":[27,75],"In":[28],"order":[29],"improve":[31],"accuracy,":[34],"much":[35],"attention":[36],"has":[37,85,157],"been":[38],"paid":[39],"improvement":[42],"performance":[45],"algorithms":[48,66],"used,":[49],"few":[50],"solving":[53],"fundamental":[55],"issue,":[56],"namely,":[57],"amino":[58,71,81,108],"acid":[59,82,109],"encoding":[60,83],"as":[61,140],"existing":[63],"pattern":[64,121],"recognition":[65,95,122],"are":[67],"unable":[68],"recognize":[70],"acids":[72],"Importantly,":[76],"commonly":[79],"used":[80],"method":[84,156],"flaw":[87],"that":[88],"leads":[89],"large":[91],"cost":[93],"and":[94,167],"bias.":[96],"RESULTS:":[97],"By":[98],"replacing":[99],"kernel":[100],"functions":[101],"support":[103],"vector":[104,142],"machines":[105],"(SVMs)":[106],"with":[107],"similarity":[110],"measurement":[111],"matrices,":[112],"we":[113],"have":[114],"modified":[115,138],"SVMs,":[116],"new":[118,155],"type":[119],"algorithm":[123],"analysing":[125],"sequences,":[127],"particularly":[128],"proteolytic":[130],"cleavage":[131,152],"site":[132],"prediction.":[133],"We":[134],"refer":[135],"SVMs":[139],"bio-support":[141],"machine.":[143],"When":[144],"applied":[145],"HIV":[150],"protease":[151],"sites,":[153],"shown":[158],"remarkable":[160],"advantage":[161],"reducing":[163],"complexity":[166],"enhancing":[168],"robustness.":[171]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}