{"id":"https://openalex.org/W2106884530","doi":"https://doi.org/10.1093/bioinformatics/btg396","title":"An empirical bayes adjustment to increase the sensitivity of detecting differentially expressed genes in microarray experiments","display_name":"An empirical bayes adjustment to increase the sensitivity of detecting differentially expressed genes in microarray experiments","publication_year":2004,"publication_date":"2004-01-20","ids":{"openalex":"https://openalex.org/W2106884530","doi":"https://doi.org/10.1093/bioinformatics/btg396","mag":"2106884530","pmid":"https://pubmed.ncbi.nlm.nih.gov/14734315"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg396","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg396","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/2/235/48905255/bioinformatics_20_2_235.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/20/2/235/48905255/bioinformatics_20_2_235.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013633090","display_name":"Susmita Datta","orcid":"https://orcid.org/0000-0002-7408-699X"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susmita Datta","raw_affiliation_strings":["Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","Department of Mathematics and Statistics , Georgia State University , Atlanta , GA 30303 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"Department of Mathematics and Statistics , Georgia State University , Atlanta , GA 30303 , USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susmita Datta","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susmita Datta","raw_affiliation_strings":["Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","Centers for Disease Control & Prevention, Atlanta, GA 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"Centers for Disease Control & Prevention, Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080945172","display_name":"Glen A. Satten","orcid":"https://orcid.org/0000-0001-7275-5371"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glen A. Satten","raw_affiliation_strings":["Department of Physiology and Biophysics,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008621245","display_name":"Dale Benos","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dale J. Benos","raw_affiliation_strings":["Department of Physiology and Biophysics,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics,#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047804035","display_name":"Jiazeng Xia","orcid":"https://orcid.org/0000-0003-0401-4824"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiazeng Xia","raw_affiliation_strings":["Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071825465","display_name":"Martin J. Heslin","orcid":"https://orcid.org/0000-0002-9932-2362"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. Heslin","raw_affiliation_strings":["Department of Statistics University of Georgia Athens, GA 30602 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics University of Georgia Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003292914","display_name":"Somnath Datta","orcid":"https://orcid.org/0000-0003-4381-1842"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somnath Datta","raw_affiliation_strings":["Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003292914","display_name":"Somnath Datta","orcid":"https://orcid.org/0000-0003-4381-1842"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Somnath Datta","raw_affiliation_strings":["Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. datta@stat.uga.edu","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003292914","https://openalex.org/A5013633090"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.9082,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.71558632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"2","first_page":"235","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.7272405624389648},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.6239026784896851},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.5607103109359741},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5598362684249878},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.4929041862487793},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.4875583052635193},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.48341524600982666},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.480502724647522},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47038140892982483},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.46263545751571655},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33538293838500977},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.321871817111969},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.30582284927368164},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.28195130825042725},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2666357755661011}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.7272405624389648},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.6239026784896851},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.5607103109359741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5598362684249878},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.4929041862487793},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.4875583052635193},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.48341524600982666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.480502724647522},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47038140892982483},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.46263545751571655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33538293838500977},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.321871817111969},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30582284927368164},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.28195130825042725},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2666357755661011},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg396","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg396","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/2/235/48905255/bioinformatics_20_2_235.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:14734315","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14734315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btg396","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg396","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/20/2/235/48905255/bioinformatics_20_2_235.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.550000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W162636959","https://openalex.org/W205781740","https://openalex.org/W1995017987","https://openalex.org/W2002415910","https://openalex.org/W2047204673","https://openalex.org/W2071650644","https://openalex.org/W2074089196","https://openalex.org/W2077788215","https://openalex.org/W2079819958","https://openalex.org/W2091841926","https://openalex.org/W2093017030","https://openalex.org/W2105793531","https://openalex.org/W2113745932","https://openalex.org/W2117135012","https://openalex.org/W2123172482","https://openalex.org/W2137784044","https://openalex.org/W2141407136","https://openalex.org/W2170989872","https://openalex.org/W2473516778","https://openalex.org/W2796856748"],"related_works":["https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W2093104131","https://openalex.org/W4300887971","https://openalex.org/W2178204436","https://openalex.org/W2143079975","https://openalex.org/W2333750400","https://openalex.org/W2113381189","https://openalex.org/W2058846847","https://openalex.org/W2906877126"],"abstract_inverted_index":{"MOTIVATION:":[0],"Detection":[1],"of":[2,8,12,38,68,101,139,152,168,188,191,199],"differentially":[3,141],"expressed":[4,142],"genes":[5,143,200,229],"is":[6,20],"one":[7],"the":[9,25,45,50,69,85,90,115,123,132,137,158,166,173,248,261],"major":[10],"goals":[11],"microarray":[13],"experiments.":[14],"Pairwise":[15],"comparison":[16],"for":[17,49,53,89,94,98,247],"each":[18,54,95,99],"gene":[19,70,96],"not":[21],"appropriate":[22],"without":[23],"controlling":[24],"overall":[26],"(experimentwise)":[27],"type":[28,103],"1":[29],"error":[30],"rate.":[31,176],"Dudoit":[32],"et":[33],"al.":[34],"have":[35],"advocated":[36],"use":[37],"permutation-based":[39],"step-down":[40,81,124,253],"P-value":[41,254],"adjustments":[42,82],"to":[43,74,83,114,145,162,214,223,232],"correct":[44,84],"observed":[46,86],"significance":[47,87],"levels":[48,72,88],"individual":[51,91],"(i.e.":[52],"gene)":[55],"two":[56],"sample":[57],"t-tests.":[58],"RESULTS:":[59],"In":[60],"this":[61],"paper,":[62],"we":[63,107,129],"consider":[64],"an":[65],"ANOVA":[66,92],"formulation":[67],"expression":[71,203],"corresponding":[73],"multiple":[75],"tissue":[76,102],"types.":[77],"We":[78,177],"provide":[79],"resampling-based":[80],"t-tests":[93],"and":[97,194,217,252],"pair":[100],"comparisons.":[104],"More":[105],"importantly,":[106],"introduce":[108],"a":[109,149,169,182],"novel":[110,242],"empirical":[111,133,249],"Bayes":[112,134,250],"adjustment":[113,135,155,251],"t-test":[116],"statistics":[117],"that":[118,131],"can":[119],"be":[120,233],"incorporated":[121],"into":[122],"procedure.":[125],"Using":[126],"simulated":[127],"data,":[128],"show":[130],"improved":[136],"sensitivity":[138],"detecting":[140],"up":[144],"16%,":[146],"while":[147],"maintaining":[148],"high":[150],"level":[151,204],"specificity.":[153],"This":[154,226],"also":[156],"reduces":[157],"false":[159,174],"non-discovery":[160],"rate":[161],"some":[163,241],"degree":[164],"at":[165],"cost":[167],"modest":[170],"increase":[171],"in":[172],"discovery":[175],"illustrate":[178],"our":[179],"approach":[180],"using":[181],"human":[183],"colon":[184,236],"cancer":[185,237],"dataset":[186],"consisting":[187],"oligonucleotide":[189],"arrays":[190],"normal,":[192],"adenoma":[193,215,222],"carcinoma":[195,224],"cells.":[196,225],"The":[197],"number":[198],"with":[201,235],"differential":[202],"declared":[205],"statistically":[206],"significant":[207],"was":[208],"about":[209,218],"50":[210],"when":[211,220],"comparing":[212,221],"normal":[213],"cells":[216],"five":[219],"list":[227],"includes":[228],"previously":[230],"known":[231],"associated":[234],"as":[238,240],"well":[239],"genes.":[243],"AVAILABILITY:":[244],"R":[245],"code":[246],"calculation":[255],"via":[256],"resampling":[257],"are":[258],"available":[259],"from":[260],"supplementary":[262],"web-site.":[263],"SUPPLEMENTARY":[264],"INFORMATION:":[265],"http://www.mathstat.gsu.edu/~matsnd/EB/supp.htm":[266]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-12T07:12:00.856984","created_date":"2025-10-10T00:00:00"}