{"id":"https://openalex.org/W2101772322","doi":"https://doi.org/10.1093/bioinformatics/btg247","title":"Examining the independent binding assumption for binding of peptide epitopes to MHC-I molecules","display_name":"Examining the independent binding assumption for binding of peptide epitopes to MHC-I molecules","publication_year":2003,"publication_date":"2003-09-22","ids":{"openalex":"https://openalex.org/W2101772322","doi":"https://doi.org/10.1093/bioinformatics/btg247","mag":"2101772322","pmid":"https://pubmed.ncbi.nlm.nih.gov/14512347"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg247","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg247","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005860852","display_name":"Bj\u00f6rn Peters","orcid":"https://orcid.org/0000-0002-2941-1335"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bj\u00f6rn Peters","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Charite, Humboldt Universit\u00e4t Berlin, Monbijoustr. 2, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Charite, Humboldt Universit\u00e4t Berlin, Monbijoustr. 2, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103552624","display_name":"Weiwei Tong","orcid":"https://orcid.org/0009-0001-2318-3191"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiwei Tong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037285448","display_name":"John Sidney","orcid":"https://orcid.org/0000-0002-0987-405X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Sidney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010966529","display_name":"Alessandro Sette","orcid":"https://orcid.org/0000-0001-7013-2250"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Sette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084369008","display_name":"Zhiping Weng","orcid":"https://orcid.org/0000-0002-3032-7966"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiping Weng","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005860852"],"corresponding_institution_ids":["https://openalex.org/I39343248"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.4207,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.93119647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"14","first_page":"1765","last_page":"1772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9478999972343445,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9478999972343445,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"Major histocompatibility complex","score":0.568902850151062},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5670653581619263},{"id":"https://openalex.org/keywords/binding-affinities","display_name":"Binding affinities","score":0.5635926127433777},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5286039710044861},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.5266956090927124},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.502842366695404},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.4839385151863098},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.46470561623573303},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34142017364501953},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3388251066207886},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3275105655193329},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.32650312781333923},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29635152220726013},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2012043297290802},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.1272926926612854},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10067141056060791},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08915987610816956}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.568902850151062},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5670653581619263},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.5635926127433777},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5286039710044861},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5266956090927124},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.502842366695404},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4839385151863098},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.46470561623573303},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34142017364501953},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3388251066207886},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3275105655193329},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32650312781333923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29635152220726013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2012043297290802},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1272926926612854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10067141056060791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08915987610816956},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg247","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg247","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:14512347","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14512347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3433608124","display_name":null,"funder_award_id":"N01-AI-95362","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5342270381","display_name":null,"funder_award_id":"RG-000426","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W38809484","https://openalex.org/W1490155859","https://openalex.org/W1560103427","https://openalex.org/W1969057879","https://openalex.org/W1988012305","https://openalex.org/W1994048581","https://openalex.org/W2012757823","https://openalex.org/W2021002908","https://openalex.org/W2024543747","https://openalex.org/W2035194338","https://openalex.org/W2041553413","https://openalex.org/W2059212728","https://openalex.org/W2066081681","https://openalex.org/W2082296437","https://openalex.org/W2116929165","https://openalex.org/W2128623999","https://openalex.org/W2152195464","https://openalex.org/W2155653793","https://openalex.org/W2166831581","https://openalex.org/W2170120409","https://openalex.org/W3085162807"],"related_works":["https://openalex.org/W2021824670","https://openalex.org/W2009867644","https://openalex.org/W2363997565","https://openalex.org/W1981120125","https://openalex.org/W3036615648","https://openalex.org/W2408448169","https://openalex.org/W2182598264","https://openalex.org/W2075879923","https://openalex.org/W1978626146","https://openalex.org/W2077117908"],"abstract_inverted_index":{"MOTIVATION:":[0],"Various":[1],"methods":[2,35,56,98,105],"have":[3],"been":[4],"proposed":[5],"to":[6,13,44,47,72,118,188],"predict":[7],"the":[8,45,74,82,102,119,127,173],"binding":[9,24,46,148],"affinities":[10],"of":[11,40,77,84,121],"peptides":[12],"Major":[14],"Histocompatibility":[15],"Complex":[16],"class":[17],"I":[18],"(MHC-I)":[19],"molecules":[20],"based":[21],"on":[22],"experimental":[23],"data.":[25],"They":[26],"can":[27,58],"be":[28],"classified":[29],"into":[30,60],"two":[31],"groups:":[32],"(1)":[33],"AIB":[34,104,184],"that":[36,101],"assume":[37],"independent":[38,147],"contributions":[39],"all":[41],"peptide":[42,87,156],"positions":[43,65],"MHC-I":[48],"molecule":[49],"(e.g.":[50,66],"scoring":[51],"matrices)":[52],"and":[53,80,95,99,168,203],"(2)":[54],"general":[55,114,128,140],"which":[57,142],"take":[59],"account":[61],"interactions":[62,85,154],"between":[63,86,155],"different":[64],"artificial":[67],"neural":[68],"networks).":[69],"We":[70,90],"aim":[71],"compare":[73],"prediction":[75,166,194],"accuracies":[76],"these":[78],"methods,":[79,115],"quantify":[81],"impact":[83],"positions.":[88,157],"RESULTS:":[89],"compared":[91],"several":[92],"previously":[93,112],"published":[94,113],"widely":[96],"used":[97],"discovered":[100],"best":[103,131],"gave":[106],"significantly":[107],"better":[108],"predictions":[109],"than":[110,172],"three":[111],"possibly":[116],"due":[117],"lack":[120],"a":[122,144],"sufficient":[123],"training":[124],"data":[125],"for":[126],"methods.":[129],"The":[130,158,192,200],"results,":[132],"however,":[133],"were":[134,169],"achieved":[135],"with":[136,149],"our":[137],"newly":[138],"developed":[139],"method,":[141],"combined":[143],"matrix":[145,174,202],"describing":[146,152],"pair":[150,159,204],"coefficients":[151,160,205],"pair-wise":[153],"consistently":[161],"but":[162],"only":[163],"slightly":[164],"improved":[165],"accuracy,":[167],"much":[170],"smaller":[171],"entries.":[175],"This":[176],"explains":[177],"why":[178],"neglecting":[179],"them-as":[180],"is":[181,196],"done":[182],"in":[183],"methods-can":[185],"still":[186],"lead":[187],"good":[189],"predictions.":[190],"AVAILABILITY:":[191],"new":[193],"model":[195],"implemented":[197],"at":[198],"http://zlab.bu.edu/SMM.":[199],"underlying":[201],"are":[206],"also":[207],"available":[208],"as":[209],"supplementary":[210],"materials.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}