{"id":"https://openalex.org/W2153153865","doi":"https://doi.org/10.1093/bioinformatics/btg224","title":"PISCES: a protein sequence culling server","display_name":"PISCES: a protein sequence culling server","publication_year":2003,"publication_date":"2003-08-11","ids":{"openalex":"https://openalex.org/W2153153865","doi":"https://doi.org/10.1093/bioinformatics/btg224","mag":"2153153865","pmid":"https://pubmed.ncbi.nlm.nih.gov/12912846"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg224","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/12/1589/718266/btg224.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/19/12/1589/718266/btg224.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100696240","display_name":"Guoli Wang","orcid":"https://orcid.org/0000-0001-7390-3188"},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guoli Wang","raw_affiliation_strings":["Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA","Institute for Cancer Research,\nFox Chase Cancer Center, 7701 Burholme Avenue,\nPhiladelphia, PA 19111, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Institute for Cancer Research,\nFox Chase Cancer Center, 7701 Burholme Avenue,\nPhiladelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053977807","display_name":"Roland L. Dunbrack","orcid":"https://orcid.org/0000-0001-7674-6667"},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland L. Dunbrack","raw_affiliation_strings":["Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA","Institute for Cancer Research,\nFox Chase Cancer Center, 7701 Burholme Avenue,\nPhiladelphia, PA 19111, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Institute for Cancer Research,\nFox Chase Cancer Center, 7701 Burholme Avenue,\nPhiladelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100696240"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":20.7038,"has_fulltext":true,"cited_by_count":1748,"citation_normalized_percentile":{"value":0.99757296,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"12","first_page":"1589","last_page":"1591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genbank","display_name":"GenBank","score":0.810405969619751},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank (RCSB PDB)","score":0.769222617149353},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6579911708831787},{"id":"https://openalex.org/keywords/identifier","display_name":"Identifier","score":0.6232752203941345},{"id":"https://openalex.org/keywords/sequence-database","display_name":"Sequence database","score":0.5942360162734985},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.5538057684898376},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5108708739280701},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.504773736000061},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3700137436389923},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19022035598754883},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.13946357369422913},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1308993697166443}],"concepts":[{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.810405969619751},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.769222617149353},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6579911708831787},{"id":"https://openalex.org/C154504017","wikidata":"https://www.wikidata.org/wiki/Q853614","display_name":"Identifier","level":2,"score":0.6232752203941345},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.5942360162734985},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.5538057684898376},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5108708739280701},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.504773736000061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3700137436389923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19022035598754883},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.13946357369422913},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1308993697166443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003205","descriptor_name":"Computing Methodologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg224","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/12/1589/718266/btg224.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12912846","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12912846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btg224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg224","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/12/1589/718266/btg224.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153153865.pdf","grobid_xml":"https://content.openalex.org/works/W2153153865.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2074231493","https://openalex.org/W2088933990","https://openalex.org/W2096525273","https://openalex.org/W2106882534","https://openalex.org/W2116449290","https://openalex.org/W2130479394","https://openalex.org/W2137995988","https://openalex.org/W2145358391","https://openalex.org/W2147809382","https://openalex.org/W2149758239","https://openalex.org/W2150556577","https://openalex.org/W2168211076","https://openalex.org/W4242739003"],"related_works":["https://openalex.org/W3132544722","https://openalex.org/W3181892255","https://openalex.org/W2116496810","https://openalex.org/W151959011","https://openalex.org/W4205671017","https://openalex.org/W2022209941","https://openalex.org/W2114930488","https://openalex.org/W2103435205","https://openalex.org/W2153153865","https://openalex.org/W2915827701"],"abstract_inverted_index":{"PISCES":[0,24,64,100],"is":[1,75],"a":[2,111,116],"public":[3],"server":[4],"for":[5],"culling":[6],"sets":[7],"of":[8,36,113],"protein":[9,61],"sequences":[10,96,105],"from":[11,29,34,50,58],"the":[12,30,43,59,108],"Protein":[13],"Data":[14],"Bank":[15],"(PDB)":[16],"by":[17,42,90,107],"sequence":[18,46,62,83,88],"identity":[19,84,89],"and":[20,85],"structural":[21],"quality":[22],"criteria.":[23],"can":[25,101],"provide":[26],"lists":[27,35,68],"culled":[28],"entire":[31],"PDB":[32,37,95],"or":[33,39,120],"entries":[38],"chains":[40],"provided":[41,106],"user.":[44],"The":[45],"identities":[47],"are":[48,97],"obtained":[49],"PSI-BLAST":[51],"alignments":[52],"with":[53],"position-specific":[54],"substitution":[55],"matrices":[56],"derived":[57],"non-redundant":[60],"database.":[63],"therefore":[65],"provides":[66],"better":[67],"than":[69],"servers":[70],"that":[71],"use":[72],"BLAST,":[73],"which":[74],"unable":[76],"to":[77],"identify":[78],"many":[79],"relationships":[80],"below":[81],"40%":[82],"often":[86],"overestimates":[87],"aligning":[91],"only":[92],"well-conserved":[93],"fragments.":[94],"updated":[98],"weekly.":[99],"also":[102],"cull":[103],"non-PDB":[104],"user":[109],"as":[110],"list":[112],"GenBank":[114],"identifiers,":[115],"FASTA":[117],"format":[118],"file,":[119],"BLAST/PSI-BLAST":[121],"output.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":50},{"year":2024,"cited_by_count":58},{"year":2023,"cited_by_count":74},{"year":2022,"cited_by_count":92},{"year":2021,"cited_by_count":98},{"year":2020,"cited_by_count":85},{"year":2019,"cited_by_count":92},{"year":2018,"cited_by_count":81},{"year":2017,"cited_by_count":78},{"year":2016,"cited_by_count":82},{"year":2015,"cited_by_count":82},{"year":2014,"cited_by_count":78},{"year":2013,"cited_by_count":105},{"year":2012,"cited_by_count":77}],"updated_date":"2026-04-12T07:58:50.170612","created_date":"2025-10-10T00:00:00"}