{"id":"https://openalex.org/W2107811186","doi":"https://doi.org/10.1093/bioinformatics/btg118","title":"Integrative approach for computationally inferringprotein domain interactions","display_name":"Integrative approach for computationally inferringprotein domain interactions","publication_year":2003,"publication_date":"2003-05-21","ids":{"openalex":"https://openalex.org/W2107811186","doi":"https://doi.org/10.1093/bioinformatics/btg118","mag":"2107811186","pmid":"https://pubmed.ncbi.nlm.nih.gov/12761053"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg118","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg118","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090171111","display_name":"See-Kiong Ng","orcid":"https://orcid.org/0000-0001-6565-7511"},"institutions":[{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"See-Kiong Ng","raw_affiliation_strings":["Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429698","display_name":"Zhuo Zhang","orcid":"https://orcid.org/0000-0001-9063-117X"},"institutions":[{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhuo Zhang","raw_affiliation_strings":["Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Soon-Heng Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Soon-Heng Tan","raw_affiliation_strings":["Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Information Technology, 21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Laboratories for Information Technology, #N#21 Heng Mui Keng Terrace, Singapore 119613","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3005327000"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.3591,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.9665715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"8","first_page":"923","last_page":"929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9016000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9016000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.7806813716888428},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.7743035554885864},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6666116714477539},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6019272208213806},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5535781383514404},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4861142635345459},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41276776790618896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2308754026889801},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11519205570220947},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08482751250267029},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07286337018013}],"concepts":[{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.7806813716888428},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.7743035554885864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6666116714477539},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6019272208213806},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5535781383514404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4861142635345459},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41276776790618896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2308754026889801},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11519205570220947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08482751250267029},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07286337018013},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg118","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg118","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12761053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12761053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1533936090","https://openalex.org/W1759990168","https://openalex.org/W1884509322","https://openalex.org/W1966421023","https://openalex.org/W1983913286","https://openalex.org/W1994025789","https://openalex.org/W2003144438","https://openalex.org/W2040022066","https://openalex.org/W2040941311","https://openalex.org/W2045131140","https://openalex.org/W2065304353","https://openalex.org/W2080922074","https://openalex.org/W2107340752","https://openalex.org/W2109715166","https://openalex.org/W2113654464","https://openalex.org/W2131581981","https://openalex.org/W2132582966","https://openalex.org/W2141885858","https://openalex.org/W2146312020","https://openalex.org/W2147809382","https://openalex.org/W2149630164","https://openalex.org/W2166558964","https://openalex.org/W2167869241"],"related_works":["https://openalex.org/W2169315304","https://openalex.org/W2499073244","https://openalex.org/W2189023396","https://openalex.org/W2045131140","https://openalex.org/W3197405877","https://openalex.org/W2010825547","https://openalex.org/W2118652015","https://openalex.org/W4213112444","https://openalex.org/W2107811186","https://openalex.org/W2145427519"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1],"current":[2],"need":[3],"for":[4,41,81],"high-throughput":[5],"protein":[6,25,62,73,87,116,118,151],"interaction":[7,12,76,94],"detection":[8],"has":[9],"resulted":[10],"in":[11,52,159],"data":[13,28,95,113],"being":[14],"generated":[15],"en":[16],"masse":[17],"through":[18],"such":[19,130],"experimental":[20],"methods":[21],"as":[22],"yeast-two-hybrids":[23],"and":[24,32,58,84,120,142],"chips.":[26],"Such":[27],"can":[29,78],"be":[30,79],"erroneous":[31],"they":[33],"often":[34],"do":[35,96],"not":[36,97],"provide":[37],"adequate":[38],"functional":[39],"information":[40,77],"the":[42,60,127,136,156],"detected":[43,61],"interactions.":[44,63,88,145],"Therefore,":[45],"it":[46],"is":[47,162],"useful":[48,80],"to":[49,55,105,140],"develop":[50],"an":[51,102,131],"silico":[53],"approach":[54,104,133],"further":[56,125],"validate":[57,143],"annotate":[59],"RESULTS:":[64],"Given":[65],"that":[66],"protein-protein":[67,144],"interactions":[68,71,110,139,153],"involve":[69],"physical":[70],"between":[72],"domains,":[74],"domain-domain":[75,93],"validating,":[82],"annotating,":[83],"even":[85],"predicting":[86],"However,":[89],"large-scale,":[90],"experimentally":[91],"determined":[92],"exist.":[98],"Here,":[99],"we":[100],"describe":[101],"integrative":[103,132],"computationally":[106],"derive":[107],"putative":[108,150],"domain":[109,138,152],"from":[111],"multiple":[112],"sources,":[114],"including":[115],"interactions,":[117],"complexes,":[119],"Rosetta":[121],"Stone":[122],"sequences.":[123],"We":[124],"prove":[126],"usefulness":[128],"of":[129,149],"by":[134],"applying":[135],"derived":[137,154],"predict":[141],"AVAILABILITY:":[146],"A":[147],"database":[148],"using":[155],"method":[157],"described":[158],"this":[160],"paper":[161],"available":[163],"at":[164],"http://interdom.lit.org.sg.":[165]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
