{"id":"https://openalex.org/W2171512516","doi":"https://doi.org/10.1093/bioinformatics/btg1013","title":"Annotation of bacterial genomes using improved phylogenomic profiles","display_name":"Annotation of bacterial genomes using improved phylogenomic profiles","publication_year":2003,"publication_date":"2003-07-03","ids":{"openalex":"https://openalex.org/W2171512516","doi":"https://doi.org/10.1093/bioinformatics/btg1013","mag":"2171512516","pmid":"https://pubmed.ncbi.nlm.nih.gov/12855445"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg1013","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg1013","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040348570","display_name":"Fran\u00e7ois Enault","orcid":"https://orcid.org/0000-0002-4968-3995"},"institutions":[{"id":"https://openalex.org/I4210128689","display_name":"Laboratoire de M\u00e9canique et d\u2019Acoustique","ror":"https://ror.org/03787ar02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210128689","https://openalex.org/I4210142724"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210136988","display_name":"D\u00e9l\u00e9gation Provence et Corse","ror":"https://ror.org/049qgqg40","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210136988","https://openalex.org/I4210139971"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"F. Enault","raw_affiliation_strings":["Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance"],"affiliations":[{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","institution_ids":["https://openalex.org/I4210128689","https://openalex.org/I4210136988","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034424670","display_name":"Karsten Suhre","orcid":"https://orcid.org/0000-0001-9638-3912"},"institutions":[{"id":"https://openalex.org/I4210128689","display_name":"Laboratoire de M\u00e9canique et d\u2019Acoustique","ror":"https://ror.org/03787ar02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210128689","https://openalex.org/I4210142724"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210136988","display_name":"D\u00e9l\u00e9gation Provence et Corse","ror":"https://ror.org/049qgqg40","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210136988","https://openalex.org/I4210139971"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K. Suhre","raw_affiliation_strings":["Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance"],"affiliations":[{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","institution_ids":["https://openalex.org/I4210128689","https://openalex.org/I4210136988","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057768395","display_name":"Chantal Abergel","orcid":"https://orcid.org/0000-0003-1875-4049"},"institutions":[{"id":"https://openalex.org/I4210136988","display_name":"D\u00e9l\u00e9gation Provence et Corse","ror":"https://ror.org/049qgqg40","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210136988","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I4210128689","display_name":"Laboratoire de M\u00e9canique et d\u2019Acoustique","ror":"https://ror.org/03787ar02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210128689","https://openalex.org/I4210142724"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Abergel","raw_affiliation_strings":["Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance"],"affiliations":[{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","institution_ids":["https://openalex.org/I4210128689","https://openalex.org/I4210136988","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076211143","display_name":"Olivier Poirot","orcid":"https://orcid.org/0000-0003-3570-7893"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210136988","display_name":"D\u00e9l\u00e9gation Provence et Corse","ror":"https://ror.org/049qgqg40","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210136988","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I4210128689","display_name":"Laboratoire de M\u00e9canique et d\u2019Acoustique","ror":"https://ror.org/03787ar02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210128689","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. Poirot","raw_affiliation_strings":["Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance"],"affiliations":[{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","institution_ids":["https://openalex.org/I4210128689","https://openalex.org/I4210136988","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066530892","display_name":"Jean\u2010Michel Claverie","orcid":"https://orcid.org/0000-0003-1424-0315"},"institutions":[{"id":"https://openalex.org/I4210136988","display_name":"D\u00e9l\u00e9gation Provence et Corse","ror":"https://ror.org/049qgqg40","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210136988","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I4210128689","display_name":"Laboratoire de M\u00e9canique et d\u2019Acoustique","ror":"https://ror.org/03787ar02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210095849","https://openalex.org/I4210128689","https://openalex.org/I4210142724"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-M. Claverie","raw_affiliation_strings":["Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance"],"affiliations":[{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589, 31 chemin Joseph Aiguier, 13009 Marseille, France","institution_ids":["https://openalex.org/I4210128689","https://openalex.org/I4210136988","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Structural and Genomic Information, CNRS - UPR 2589,\n31 chemin Joseph Aiguier, 13009 Marseille,\nFrance","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040348570"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128689","https://openalex.org/I4210136988"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.2208,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.78071453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"suppl_1","first_page":"i105","last_page":"i107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.7129577398300171},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6857739686965942},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6215987801551819},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.5677428245544434},{"id":"https://openalex.org/keywords/phylogenomics","display_name":"Phylogenomics","score":0.5642918944358826},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5363816618919373},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.48420193791389465},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46088480949401855},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.44607168436050415},{"id":"https://openalex.org/keywords/bacterial-genome-size","display_name":"Bacterial genome size","score":0.4426957964897156},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4358954429626465},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3064571022987366},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27205270528793335},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.25780999660491943},{"id":"https://openalex.org/keywords/clade","display_name":"Clade","score":0.24362239241600037}],"concepts":[{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.7129577398300171},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6857739686965942},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6215987801551819},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5677428245544434},{"id":"https://openalex.org/C70343354","wikidata":"https://www.wikidata.org/wiki/Q3381973","display_name":"Phylogenomics","level":5,"score":0.5642918944358826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5363816618919373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48420193791389465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46088480949401855},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44607168436050415},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.4426957964897156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4358954429626465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3064571022987366},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27205270528793335},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.25780999660491943},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.24362239241600037}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004282","descriptor_name":"Documentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004282","descriptor_name":"Documentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004282","descriptor_name":"Documentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg1013","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg1013","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12855445","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12855445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2057885377","https://openalex.org/W2079131652","https://openalex.org/W2158714788","https://openalex.org/W2160453515","https://openalex.org/W2161012147"],"related_works":["https://openalex.org/W2380915035","https://openalex.org/W2298047311","https://openalex.org/W4242909373","https://openalex.org/W2361861616","https://openalex.org/W1997697005","https://openalex.org/W2308248996","https://openalex.org/W1989895641","https://openalex.org/W4382652642","https://openalex.org/W2467039083","https://openalex.org/W2022339818"],"abstract_inverted_index":{"The":[0,27,73,118],"method":[1,77,119],"presented":[2],"here":[3],"increases":[4],"the":[5,21,91,114,136,142,154],"number":[6],"of":[7,29,45,75,85,87,98,110,144,153,159],"Ecocyc":[8],"enzymes":[9],"identified":[10],"as":[11],"being":[12],"evolutionarily":[13],"related":[14,52],"by":[15,71],"about":[16],"25%":[17],"with":[18,62],"respect":[19],"to":[20,34,53,68,113,124,132],"original":[22],"binary":[23],"form":[24,158],"(absent/present)":[25],"method.":[26],"fraction":[28],"'false'":[30],"positives":[31],"is":[32,60],"shown":[33],"be":[35,50,69,104,121],"smaller":[36],"than":[37],"20%.":[38],"Based":[39],"on":[40,81,135],"their":[41],"phylogenomic":[42],"relationships,":[43],"genes":[44,86],"unknown":[46],"function":[47,89,100],"can":[48,103,120],"then":[49],"automatically":[51],"annotated":[54],"genes.":[55],"Each":[56],"gene":[57,116],"annotation":[58],"predicted":[59],"associated":[61],"a":[63,82,107,150],"p-value,":[64],"i.e.":[65],"its":[66],"probability":[67],"obtained":[70],"chance.":[72],"validity":[74],"this":[76],"was":[78],"extensively":[79],"tested":[80],"large":[83],"set":[84],"known":[88],"using":[90],"MultiFun":[92],"database.":[93],"We":[94],"find":[95],"that":[96,102],"50%":[97],"3122":[99],"attributions":[101],"made":[105],"at":[106],"p-value":[108],"level":[109],"10(-11)":[111],"correspond":[112],"actual":[115],"annotation.":[117],"readily":[122],"applied":[123],"any":[125],"newly":[126],"sequenced":[127],"microbial":[128],"genome.":[129],"In":[130],"contrast":[131],"earlier":[133],"work":[134],"same":[137],"topic,":[138],"our":[139],"approach":[140],"avoids":[141],"use":[143],"arbitrary":[145],"cut-off":[146],"values,":[147],"and":[148],"provides":[149],"reliability":[151],"estimate":[152],"functional":[155],"predictions":[156],"in":[157],"p-values.":[160]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}