{"id":"https://openalex.org/W2161616234","doi":"https://doi.org/10.1093/bioinformatics/btg084","title":"A survey of the Predictive Toxicology Challenge 2000\u20132001","display_name":"A survey of the Predictive Toxicology Challenge 2000\u20132001","publication_year":2003,"publication_date":"2003-06-30","ids":{"openalex":"https://openalex.org/W2161616234","doi":"https://doi.org/10.1093/bioinformatics/btg084","mag":"2161616234","pmid":"https://pubmed.ncbi.nlm.nih.gov/12835259"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg084","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg084","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/10/1179/48903772/bioinformatics_19_10_1179.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/19/10/1179/48903772/bioinformatics_19_10_1179.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066862195","display_name":"Christoph Helma","orcid":"https://orcid.org/0000-0002-2640-798X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4210122148","display_name":"University of Education Freiburg","ror":"https://ror.org/02rtsfd15","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210122148"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Helma","raw_affiliation_strings":["Machine Learning Lab, University Freiburg, D-79110 Freiburg, Germany","Machine Learning Lab, University Freiburg, D-79110 Freiburg,\n Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Learning Lab, University Freiburg, D-79110 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I4210122148"]},{"raw_affiliation_string":"Machine Learning Lab, University Freiburg, D-79110 Freiburg,\n Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006247481","display_name":"Stefan Kr\u00e4mer","orcid":"https://orcid.org/0000-0002-0071-9344"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4210122148","display_name":"University of Education Freiburg","ror":"https://ror.org/02rtsfd15","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210122148"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Kramer","raw_affiliation_strings":["Machine Learning Lab, University Freiburg, D-79110 Freiburg, Germany","Machine Learning Lab, University Freiburg, D-79110 Freiburg,\n Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Learning Lab, University Freiburg, D-79110 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I4210122148"]},{"raw_affiliation_string":"Machine Learning Lab, University Freiburg, D-79110 Freiburg,\n Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.8153,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.96597675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"10","first_page":"1179","last_page":"1182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.522271454334259},{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.4863665699958801},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.48129788041114807},{"id":"https://openalex.org/keywords/toxicology","display_name":"Toxicology","score":0.400409996509552},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1838354766368866},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16103646159172058}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.522271454334259},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4863665699958801},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.48129788041114807},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.400409996509552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1838354766368866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16103646159172058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006078","descriptor_name":"Government Programs","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D006078","descriptor_name":"Government Programs","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D006078","descriptor_name":"Government Programs","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg084","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg084","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/10/1179/48903772/bioinformatics_19_10_1179.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12835259","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12835259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btg084","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg084","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/19/10/1179/48903772/bioinformatics_19_10_1179.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161616234.pdf","grobid_xml":"https://content.openalex.org/works/W2161616234.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W22405845","https://openalex.org/W1577590266","https://openalex.org/W1975147762","https://openalex.org/W1981390668","https://openalex.org/W1984182528","https://openalex.org/W1994204218","https://openalex.org/W1996103084","https://openalex.org/W2025167103","https://openalex.org/W2033800905","https://openalex.org/W2090382722","https://openalex.org/W2092202938","https://openalex.org/W2096942889","https://openalex.org/W2116214081","https://openalex.org/W2121406124","https://openalex.org/W2121831625","https://openalex.org/W2127057179","https://openalex.org/W2166741044","https://openalex.org/W2949703874","https://openalex.org/W4238105511","https://openalex.org/W4245970435","https://openalex.org/W4256548683"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"The":[2,20,77],"Predictive":[3],"Toxicology":[4,45],"Challenge":[5],"(PTC)":[6],"was":[7,25,83],"initiated":[8],"to":[9,26,64,108,114],"stimulate":[10],"the":[11,31,38,42,66,73,80,92,110],"development":[12],"of":[13,22,33,41,51,79,91],"advanced":[14],"techniques":[15],"for":[16,30,53,105,145],"predictive":[17,68],"toxicology":[18],"models.":[19],"goal":[21],"this":[23],"challenge":[24],"compare":[27],"different":[28],"approaches":[29],"prediction":[32],"rodent":[34],"carcinogenicity,":[35],"based":[36],"on":[37,59],"experimental":[39],"results":[40],"US":[43],"National":[44],"Program":[46],"(NTP).":[47],"Results:":[48],"111":[49],"sets":[50],"predictions":[52,82],"185":[54],"compounds":[55],"have":[56],"been":[57],"evaluated":[58],"quantitative":[60],"and":[61,70,86,113,125],"qualitative":[62],"scales":[63],"select":[65],"most":[67,93],"models":[69,95,112],"those":[71],"with":[72,119],"highest":[74],"toxicological":[75,97,120],"relevance.":[76],"accuracy":[78],"submitted":[81,111],"between":[84],"25":[85],"79":[87],"%.":[88],"An":[89],"evaluation":[90],"accurate":[94],"by":[96],"experts":[98,107],"showed,":[99],"that":[100],"it":[101],"is":[102],"still":[103],"hard":[104],"domain":[106],"interpret":[109],"put":[115],"them":[116],"into":[117],"relation":[118],"knowledge.":[121],"Availability:":[122],"PTC":[123],"details":[124],"data":[126],"can":[127],"be":[128,139],"found":[129],"at:":[130],"http://www.predictive-toxicology.org/ptc/":[131],"Contact:":[132],"helma@informatik.uni-freiburg.de":[133],"*":[134],"To":[135],"whom":[136],"correspondence":[137],"should":[138],"addressed.":[140],"\u2020":[141],"Present":[142],"address:":[143],"Institute":[144],"Computer":[146],"Science,":[147],"Technical":[148],"University":[149],"Munich,":[150],"D-85748,":[151],"Garching,":[152],"Germany.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}
