{"id":"https://openalex.org/W2110785001","doi":"https://doi.org/10.1093/bioinformatics/btg075","title":"Automated generation and refinement of protein signatures: case study with G-protein coupled receptors","display_name":"Automated generation and refinement of protein signatures: case study with G-protein coupled receptors","publication_year":2003,"publication_date":"2003-04-11","ids":{"openalex":"https://openalex.org/W2110785001","doi":"https://doi.org/10.1093/bioinformatics/btg075","mag":"2110785001","pmid":"https://pubmed.ncbi.nlm.nih.gov/12691984"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg075","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg075","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027618601","display_name":"Michael I. Sadowski","orcid":"https://orcid.org/0000-0002-4546-2159"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael I. Sadowski","raw_affiliation_strings":["School of Biochemistry and Molecular Biology, The University of Leeds, Leeds LS2 9JT, UK","School of Biochemistry and Molecular Biology, The University#N#of Leeds, Leeds LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Molecular Biology, The University of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Biochemistry and Molecular Biology, The University#N#of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111826355","display_name":"J.H. Parish","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Howard Parish","raw_affiliation_strings":["School of Biochemistry and Molecular Biology, The University of Leeds, Leeds LS2 9JT, UK","School of Biochemistry and Molecular Biology, The University#N#of Leeds, Leeds LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Molecular Biology, The University of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Biochemistry and Molecular Biology, The University#N#of Leeds, Leeds LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6841,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67746345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"6","first_page":"727","last_page":"734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.750327467918396},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5888835787773132},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5850483775138855},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.5837556719779968},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.5789645910263062},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.538950502872467},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5371848344802856},{"id":"https://openalex.org/keywords/superfamily","display_name":"SUPERFAMILY","score":0.4891243577003479},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.4809245765209198},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4522444009780884},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.42648977041244507},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.42356327176094055},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36653369665145874},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3636058568954468},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3586884140968323},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2973073720932007},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24791008234024048},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.23326700925827026},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23108899593353271},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17698267102241516},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12350970506668091}],"concepts":[{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.750327467918396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5888835787773132},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5850483775138855},{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.5837556719779968},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5789645910263062},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.538950502872467},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5371848344802856},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.4891243577003479},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4809245765209198},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4522444009780884},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.42648977041244507},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.42356327176094055},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36653369665145874},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3636058568954468},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3586884140968323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2973073720932007},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24791008234024048},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.23326700925827026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23108899593353271},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17698267102241516},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12350970506668091},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg075","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg075","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12691984","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12691984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1566039206","https://openalex.org/W1964100022","https://openalex.org/W1982866036","https://openalex.org/W2002337678","https://openalex.org/W2003144438","https://openalex.org/W2005342628","https://openalex.org/W2016770664","https://openalex.org/W2022447134","https://openalex.org/W2027122912","https://openalex.org/W2028291036","https://openalex.org/W2033321514","https://openalex.org/W2037882691","https://openalex.org/W2039214844","https://openalex.org/W2045884212","https://openalex.org/W2073110681","https://openalex.org/W2086835754","https://openalex.org/W2106882534","https://openalex.org/W2115399262","https://openalex.org/W2116949924","https://openalex.org/W2118601726","https://openalex.org/W2124331814","https://openalex.org/W2133067333","https://openalex.org/W2137714679","https://openalex.org/W2143210482","https://openalex.org/W2144319229","https://openalex.org/W2149963584","https://openalex.org/W2150716330","https://openalex.org/W2151831732","https://openalex.org/W2163865126","https://openalex.org/W2213326431","https://openalex.org/W2418712780","https://openalex.org/W2916193864","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2051969447","https://openalex.org/W2111937814","https://openalex.org/W2162923930","https://openalex.org/W1482324242","https://openalex.org/W2133116680","https://openalex.org/W2187357871","https://openalex.org/W2091518964","https://openalex.org/W2804480386","https://openalex.org/W3186624150","https://openalex.org/W65850283"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Previous":[2],"work":[3],"had":[4],"established":[5,102],"that":[6],"it":[7],"was":[8,91,135],"possible":[9],"to":[10,113,137],"derive":[11],"sparse":[12],"signatures":[13,44,60],"(essentially":[14],"sequence-length":[15],"motifs)":[16],"by":[17],"examining":[18],"points":[19],"of":[20,26,88,96,118,143,148],"contact":[21],"between":[22],"residues":[23],"in":[24],"proteins":[25],"known":[27],"three-dimensional":[28],"(3D)":[29],"structure.":[30],"Many":[31],"interesting":[32],"protein":[33,59,62],"families":[34],"have":[35],"very":[36],"little":[37],"tertiary":[38],"structural":[39],"information.":[40],"Methods":[41],"for":[42,57,146,157],"deriving":[43,58],"using":[45,61],"only":[46],"primary":[47],"and":[48,65,98,127,160],"secondary-structural":[49],"information":[50,64,139],"were":[51],"therefore":[52],"developed.":[53],"Results:":[54],"Two":[55],"methods":[56],"sequence":[63,126],"predicted":[66],"secondary":[67],"structures":[68],"are":[69,163],"described.":[70],"One":[71],"method":[72,90,110],"is":[73,111],"based":[74],"on":[75,81,93,140],"a":[76],"scoring":[77],"approach,":[78],"the":[79,82,89,94,101,122],"other":[80],"Genetic":[83],"Algorithm":[84],"(GA).":[85],"The":[86,108,132],"effectiveness":[87],"tested":[92],"superfamily":[95,119],"GPCRs":[97],"compared":[99],"with":[100],"hidden":[103],"Markov":[104],"model":[105],"(HMM)":[106],"method.":[107],"signature":[109],"shown":[112],"perform":[114],"well,":[115],"detecting":[116,128],"68%":[117],"members":[120],"before":[121],"first":[123],"false":[124],"positive":[125],"several":[129],"distant":[130],"relationships.":[131],"GA":[133],"population":[134],"used":[136],"provide":[138],"alignment":[141],"regions":[142],"particular":[144],"importance":[145],"selection":[147],"key":[149],"residues.":[150],"Contact:":[151],"howard@bmb.leeds.ac.uk":[152],"Supplementary":[153],"information:":[154],"Software":[155],"developed":[156],"this":[158],"project":[159],"further":[161],"data":[162],"available":[164],"online":[165],"(http://bbsrc-bioinf.leeds.ac.uk/BIOINF/jhp/)":[166],"*":[167],"To":[168],"whom":[169],"correspondence":[170],"should":[171],"be":[172],"addressed.":[173]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2016-06-24T00:00:00"}