{"id":"https://openalex.org/W2041608431","doi":"https://doi.org/10.1093/bioinformatics/btg069","title":"Computer simulation of the cellular arrangement using physical model in early cleavage of the nematode Caenorhabditis elegans","display_name":"Computer simulation of the cellular arrangement using physical model in early cleavage of the nematode Caenorhabditis elegans","publication_year":2003,"publication_date":"2003-04-11","ids":{"openalex":"https://openalex.org/W2041608431","doi":"https://doi.org/10.1093/bioinformatics/btg069","mag":"2041608431","pmid":"https://pubmed.ncbi.nlm.nih.gov/12691982"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg069","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg069","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065424880","display_name":"Atsushi Kajita","orcid":null},"institutions":[{"id":"https://openalex.org/I113198587","display_name":"National Institute of Genetics","ror":"https://ror.org/02xg1m795","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113198587","https://openalex.org/I1319490839","https://openalex.org/I4210158934"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kajita","raw_affiliation_strings":["Genome Biology Laboratory, National Institute of Genetics, 1111 Yata, Mishima, 411-8540, Japan. akajita@lab.nig.ac.jp","Genome Biology Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Biology Laboratory, National Institute of Genetics, 1111 Yata, Mishima, 411-8540, Japan. akajita@lab.nig.ac.jp","institution_ids":["https://openalex.org/I113198587"]},{"raw_affiliation_string":"Genome Biology Laboratory, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan","institution_ids":["https://openalex.org/I113198587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144139","display_name":"Masayuki Yamamura","orcid":"https://orcid.org/0000-0001-6113-3796"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Yamamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020422862","display_name":"Yuji Kohara","orcid":"https://orcid.org/0000-0002-5980-5255"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Kohara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0639,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.35410177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"19","issue":"6","first_page":"704","last_page":"716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9093491435050964},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.5377936363220215},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5120454430580139},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5001523494720459},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.4970298111438751},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48030227422714233},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4791221618652344},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.45786550641059875},{"id":"https://openalex.org/keywords/cleavage","display_name":"Cleavage (geology)","score":0.4573184847831726},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.4321572482585907},{"id":"https://openalex.org/keywords/cellular-automaton","display_name":"Cellular automaton","score":0.42027124762535095},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4026586413383484},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29065969586372375},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1785670518875122},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15526941418647766},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.134699285030365}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.9093491435050964},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5377936363220215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5120454430580139},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5001523494720459},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4970298111438751},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48030227422714233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4791221618652344},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.45786550641059875},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4573184847831726},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4321572482585907},{"id":"https://openalex.org/C35527583","wikidata":"https://www.wikidata.org/wiki/Q189156","display_name":"Cellular automaton","level":2,"score":0.42027124762535095},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4026586413383484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29065969586372375},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1785670518875122},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15526941418647766},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.134699285030365},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btg069","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg069","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:12691982","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12691982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5299999713897705,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1564690864","https://openalex.org/W1956309974","https://openalex.org/W1978555647","https://openalex.org/W1980259704","https://openalex.org/W1989952069","https://openalex.org/W1997383129","https://openalex.org/W2000690667","https://openalex.org/W2010985163","https://openalex.org/W2059130928","https://openalex.org/W2062118692","https://openalex.org/W2091153798","https://openalex.org/W2097664711","https://openalex.org/W2099269203","https://openalex.org/W2137528681","https://openalex.org/W2139020009","https://openalex.org/W2140000393"],"related_works":["https://openalex.org/W2971505853","https://openalex.org/W2465065470","https://openalex.org/W4297906920","https://openalex.org/W3041017960","https://openalex.org/W1971840302","https://openalex.org/W2013960851","https://openalex.org/W4206310443","https://openalex.org/W1556437567","https://openalex.org/W2518550345","https://openalex.org/W2086868805"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,121,159],"ultimate":[2],"goal":[3],"of":[4,33,40,79,104,135,142,161],"bioinformatics":[5],"is":[6,21,68,85,123],"to":[7,23,36,94,110,149],"reconstruct":[8],"biological":[9,15],"systems":[10,16],"in":[11,51,60,146,156],"the":[12,37,41,48,77,105,111,132,140,151,162,165],"computer.":[13,97],"Since":[14],"have":[17],"many":[18],"levels,":[19],"it":[20],"important":[22,58],"focus":[24,46],"on":[25,47,126],"an":[26],"appropriate":[27],"level.":[28],"In":[29],"our":[30],"first":[31],"application":[32],"computer":[34,102,147],"modeling":[35],"early":[38,52],"development":[39],"nematode":[42],"Caenorhabditis":[43],"elegans,":[44],"we":[45],"cellular":[49,153],"arrangement":[50],"embryos.":[53,158],"This":[54],"plays":[55],"a":[56,71,101,115],"very":[57],"role":[59],"cell":[61],"fate":[62],"determination":[63],"by":[64,88,96],"cell-cell":[65],"interaction,":[66],"and":[67,117,164],"regarded":[69],"as":[70,155],"system,":[72],"one":[73],"level":[74],"higher":[75],"than":[76],"system":[78],"gene":[80],"regulation":[81],"within":[82],"cells.":[83],"It":[84],"largely":[86],"restricted":[87],"physical":[89],"conditions":[90],"that":[91,131,138],"seemed":[92],"feasible":[93],"model":[95,103,122,163],"RESULTS:":[98],"We":[99,129],"constructed":[100],"C.elegans":[106],"embryo,":[107],"currently":[108],"up":[109],"4-cell":[112],"stage,":[113],"using":[114],"deformable":[116],"dividable":[118],"triangulated":[119],"network.":[120],"based":[124],"solely":[125],"cellular-level":[127],"dynamics.":[128],"found":[130],"optimal":[133],"ranges":[134],"three":[136],"parameters":[137],"affect":[139],"elongation":[141],"dividing":[143],"cells":[144],"led,":[145],"simulations,":[148],"almost":[150],"same":[152],"arrangements":[154],"real":[157,168],"nature":[160],"relationship":[166],"with":[167],"embryos":[169],"are":[170],"discussed.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
