{"id":"https://openalex.org/W7141850589","doi":"https://doi.org/10.1093/bioinformatics/btag158","title":"ONEST: a web-based platform for the rapid and robust analysis of protein excited states through CEST spectroscopy","display_name":"ONEST: a web-based platform for the rapid and robust analysis of protein excited states through CEST spectroscopy","publication_year":2026,"publication_date":"2026-03-26","ids":{"openalex":"https://openalex.org/W7141850589","doi":"https://doi.org/10.1093/bioinformatics/btag158","pmid":"https://pubmed.ncbi.nlm.nih.gov/41902832"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btag158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag158","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btag158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Joonhyeok Choi","orcid":"https://orcid.org/0000-0002-3800-0394"},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joonhyeok Choi","raw_affiliation_strings":["Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","Department of Applied Pharmacy, College of Pharmacy, Chungbuk National University , Cheongju, 28160,"],"raw_orcid":"https://orcid.org/0000-0002-3800-0394","affiliations":[{"raw_affiliation_string":"Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"Department of Applied Pharmacy, College of Pharmacy, Chungbuk National University , Cheongju, 28160,","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100600363","display_name":"Sang-Yeop Lee","orcid":"https://orcid.org/0000-0002-8257-6112"},"institutions":[{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sang-Yeop Lee","raw_affiliation_strings":["Center for Target-to-Therapeutics Research, Korea Basic Science Institute , Cheongju, 28119,","Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Target-to-Therapeutics Research, Korea Basic Science Institute , Cheongju, 28119,","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,","institution_ids":["https://openalex.org/I4210119461"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kyungdoe Han","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyungdoe Han","raw_affiliation_strings":["Department of Civil and Environmental Engineering, University of Wisconsin\u2014Madison , Madison, WI 53706,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, University of Wisconsin\u2014Madison , Madison, WI 53706,","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046041387","display_name":"Marta G. Carneiro","orcid":"https://orcid.org/0000-0001-7827-1685"},"institutions":[{"id":"https://openalex.org/I2801076334","display_name":"Chester Zoo","ror":"https://ror.org/01ysrp540","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2801076334"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta G Carneiro","raw_affiliation_strings":["ZoBio B.V , Leiden, 2333 CH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZoBio B.V , Leiden, 2333 CH,","institution_ids":["https://openalex.org/I2801076334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078652028","display_name":"Kyoung\u2010Seok Ryu","orcid":"https://orcid.org/0000-0002-8422-6669"},"institutions":[{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Kyoung-Seok Ryu","raw_affiliation_strings":["Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,","institution_ids":["https://openalex.org/I4210119461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007020226","display_name":"Donghan Lee","orcid":"https://orcid.org/0000-0002-3971-986X"},"institutions":[{"id":"https://openalex.org/I4210119461","display_name":"Convergent Science (United States)","ror":"https://ror.org/02f4p4v04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119461"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Donghan Lee","raw_affiliation_strings":["Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,"],"raw_orcid":"https://orcid.org/0000-0002-3971-986X","affiliations":[{"raw_affiliation_string":"Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute , Cheongju, 28119,","institution_ids":["https://openalex.org/I4210139925"]},{"raw_affiliation_string":"Department of Convergent Analytical Science, University of Science and Technology , Daejeon, 34113,","institution_ids":["https://openalex.org/I4210119461"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007020226"],"corresponding_institution_ids":["https://openalex.org/I4210119461","https://openalex.org/I4210139925"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29723915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.5623000264167786,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.5623000264167786,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/degeneracy","display_name":"Degeneracy (biology)","score":0.5849999785423279},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.505299985408783},{"id":"https://openalex.org/keywords/excited-state","display_name":"Excited state","score":0.5},{"id":"https://openalex.org/keywords/spectroscopy","display_name":"Spectroscopy","score":0.4821000099182129},{"id":"https://openalex.org/keywords/saturation","display_name":"Saturation (graph theory)","score":0.4645000100135803},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.44929999113082886},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance-spectroscopy","display_name":"Nuclear magnetic resonance spectroscopy","score":0.376800000667572},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.37070000171661377}],"concepts":[{"id":"https://openalex.org/C2777727622","wikidata":"https://www.wikidata.org/wiki/Q5251772","display_name":"Degeneracy (biology)","level":2,"score":0.5849999785423279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5440999865531921},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.505299985408783},{"id":"https://openalex.org/C181500209","wikidata":"https://www.wikidata.org/wiki/Q215328","display_name":"Excited state","level":2,"score":0.5},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4984000027179718},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.46799999475479126},{"id":"https://openalex.org/C9930424","wikidata":"https://www.wikidata.org/wiki/Q7426587","display_name":"Saturation (graph theory)","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C30475298","wikidata":"https://www.wikidata.org/wiki/Q909554","display_name":"Computational physics","level":1,"score":0.43860000371932983},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.37389999628067017},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.37070000171661377},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35600000619888306},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C15845906","wikidata":"https://www.wikidata.org/wiki/Q1172338","display_name":"Data exchange","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C184389593","wikidata":"https://www.wikidata.org/wiki/Q603159","display_name":"Curve fitting","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2696000039577484},{"id":"https://openalex.org/C19549132","wikidata":"https://www.wikidata.org/wiki/Q11141463","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","level":2,"score":0.26429998874664307}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btag158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag158","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41902832","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41902832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13070701","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13070701/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btag158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag158","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6096856274","display_name":null,"funder_award_id":"C623200","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G6721392810","display_name":null,"funder_award_id":"C625130","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G7538056602","display_name":null,"funder_award_id":"C623300","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G762962293","display_name":null,"funder_award_id":"C612120","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"},{"id":"https://openalex.org/G8283393202","display_name":null,"funder_award_id":"C539110","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"}],"funders":[{"id":"https://openalex.org/F4320322111","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W771715831","https://openalex.org/W1432161153","https://openalex.org/W1983559907","https://openalex.org/W1996859443","https://openalex.org/W2001575435","https://openalex.org/W2007365965","https://openalex.org/W2008422351","https://openalex.org/W2009239521","https://openalex.org/W2052045126","https://openalex.org/W2054191418","https://openalex.org/W2055557864","https://openalex.org/W2060770036","https://openalex.org/W2086739475","https://openalex.org/W2120817777","https://openalex.org/W2149860949","https://openalex.org/W2315483642","https://openalex.org/W2329582709","https://openalex.org/W2426024991","https://openalex.org/W2597024964","https://openalex.org/W2925188014","https://openalex.org/W2951531210","https://openalex.org/W3003257820","https://openalex.org/W4211074093","https://openalex.org/W4235425095","https://openalex.org/W4288751345"],"related_works":[],"abstract_inverted_index":{"SUMMARY:":[0],"The":[1],"biological":[2],"function":[3],"of":[4,40,47,156,180,186,203],"proteins":[5],"is":[6,29,218],"often":[7],"driven":[8],"by":[9,18,116],"\"invisible\"":[10],"excited":[11],"states-transient,":[12],"low-population":[13],"conformations":[14],"that":[15,85,138],"remain":[16],"undetectable":[17],"conventional":[19],"structural":[20],"methods.":[21],"Chemical":[22],"Exchange":[23,64],"Saturation":[24,65],"Transfer":[25],"(CEST)":[26],"NMR":[27],"spectroscopy":[28],"a":[30,67,80,104,154,177,200],"powerful":[31],"technique":[32],"for":[33,90,107],"characterizing":[34],"these":[35,57],"states;":[36],"however,":[37],"the":[38,44,139,157,163,184,194,221],"complexity":[39],"data":[41],"analysis":[42],"and":[43,74,112,188],"computational":[45,158],"cost":[46],"numerical":[48,99],"fitting":[49,83,118],"have":[50],"hindered":[51],"its":[52],"widespread":[53],"adoption.":[54],"To":[55],"address":[56],"challenges,":[58],"we":[59],"present":[60],"ONEST":[61,78,191,217],"(Optimized":[62],"Novel":[63],"Transfer),":[66],"user-friendly":[68],"web":[69,222],"server":[70,223],"designed":[71],"to":[72,148,162,197,205],"automate":[73],"accelerate":[75],"CEST":[76],"analysis.":[77],"utilizes":[79],"simultaneous":[81],"multi-field":[82],"algorithm":[84],"leverages":[86],"exact":[87],"analytical":[88,140],"solutions":[89],"two-state":[91],"exchange":[92,171],"(Baldwin":[93],"model)":[94],"rather":[95],"than":[96],"computationally":[97],"intensive":[98],"integration.":[100],"This":[101],"approach":[102,141],"incorporates":[103],"rigorous":[105],"correction":[106],"radio-frequency":[108],"(RF)":[109],"field":[110,124],"inhomogeneity":[111],"resolves":[113],"parameter":[114],"degeneracy":[115],"jointly":[117],"datasets":[119,129],"acquired":[120],"at":[121,153,209,224],"distinct":[122],"RF":[123],"strengths.":[125],"Validation":[126],"against":[127],"synthetic":[128],"yielded":[130],"reduced":[131],"c2":[132],"values":[133],"near":[134],"unity":[135],"(\u223c1.05),":[136],"confirming":[137],"recovers":[142],"kinetic":[143,187],"parameters":[144],"with":[145],"accuracy":[146],"comparable":[147],"full":[149],"Bloch-McConnell":[150],"simulations":[151],"but":[152],"fraction":[155],"cost.":[159],"Furthermore,":[160],"application":[161],"anti-HIV":[164],"lectin":[165],"OAA":[166],"successfully":[167],"characterized":[168],"slow":[169],"conformational":[170],"(kex":[172],"=":[173],"279":[174],"s-1)":[175],"involving":[176],"minor":[178],"population":[179],"3%.":[181],"By":[182],"streamlining":[183],"extraction":[185],"thermodynamic":[189],"parameters,":[190],"significantly":[192],"lowers":[193],"technical":[195],"barrier":[196],"entry,":[198],"enabling":[199],"broader":[201],"range":[202],"researchers":[204],"investigate":[206],"protein":[207],"dynamics":[208],"atomic":[210],"resolution.":[211],"CONTACT:":[212],"dlee04@kbsi.re.kr.":[213],"AVAILABILITY":[214],"AND":[215],"IMPLEMENTATION:":[216],"available":[219],"through":[220],"http://onest.ai.kr.":[225]},"counts_by_year":[],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2026-03-29T00:00:00"}