{"id":"https://openalex.org/W7135186717","doi":"https://doi.org/10.1093/bioinformatics/btag065","title":"Topological model selection: a case-study in tumour-induced angiogenesis","display_name":"Topological model selection: a case-study in tumour-induced angiogenesis","publication_year":2026,"publication_date":"2026-02-28","ids":{"openalex":"https://openalex.org/W7135186717","doi":"https://doi.org/10.1093/bioinformatics/btag065","pmid":"https://pubmed.ncbi.nlm.nih.gov/41818692"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btag065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag065","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btag065","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert A McDonald","orcid":"https://orcid.org/0009-0003-2227-6622"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210120676","display_name":"Mathematical Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02fhy7464","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210120676"]}],"countries":["GB","SK"],"is_corresponding":false,"raw_author_name":"Robert A McDonald","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,"],"raw_orcid":"https://orcid.org/0009-0003-2227-6622","affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,","institution_ids":["https://openalex.org/I4210120676","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Helen M Byrne","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106789","display_name":"Ludwig Cancer Research","ror":"https://ror.org/01e473h50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210106789","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210120676","display_name":"Mathematical Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02fhy7464","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210120676"]}],"countries":["GB","SK"],"is_corresponding":false,"raw_author_name":"Helen M Byrne","raw_affiliation_strings":["Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,","Nuffield Department of Medicine, Ludwig Institute for Cancer Research , Oxford OX3 7DQ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,","institution_ids":["https://openalex.org/I4210120676","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Medicine, Ludwig Institute for Cancer Research , Oxford OX3 7DQ,","institution_ids":["https://openalex.org/I4210106789"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather A Harrington","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210120676","display_name":"Mathematical Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02fhy7464","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210120676"]},{"id":"https://openalex.org/I4210148197","display_name":"Center for Systems Biology Dresden","ror":"https://ror.org/05hrn3e05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I149899117","https://openalex.org/I4210111875","https://openalex.org/I4210148197","https://openalex.org/I4210159854","https://openalex.org/I78650965"]},{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE","GB","SK"],"is_corresponding":false,"raw_author_name":"Heather A Harrington","raw_affiliation_strings":["Centre for Systems Biology Dresden (CSBD) , Dresden 01062,","Faculty of Mathematics, Technische Universitat Dresden , Dresden 01062,","Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,","Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) , Dresden 01307,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Systems Biology Dresden (CSBD) , Dresden 01062,","institution_ids":["https://openalex.org/I4210148197"]},{"raw_affiliation_string":"Faculty of Mathematics, Technische Universitat Dresden , Dresden 01062,","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter , Oxford OX2 6GG,","institution_ids":["https://openalex.org/I4210120676","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) , Dresden 01307,","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Thorne","orcid":"https://orcid.org/0000-0002-7396-5116"},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thomas Thorne","raw_affiliation_strings":["Computer Science Research Centre, University of Surrey, Guildford GU2 7XH,"],"raw_orcid":"https://orcid.org/0000-0002-7396-5116","affiliations":[{"raw_affiliation_string":"Computer Science Research Centre, University of Surrey, Guildford GU2 7XH,","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bernadette J Stolz","orcid":"https://orcid.org/0000-0001-8658-8666"},"institutions":[{"id":"https://openalex.org/I292141241","display_name":"Munich School of Philosophy","ror":"https://ror.org/02kqy4228","country_code":"DE","type":"education","lineage":["https://openalex.org/I292141241"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernadette J Stolz","raw_affiliation_strings":["Department of Machine Learning and Systems Biology, Max Planck Institute of Biochemistry , Martinsried 82152,","Munich Center for Machine Learning , Munich, 80538,"],"raw_orcid":"https://orcid.org/0000-0001-8658-8666","affiliations":[{"raw_affiliation_string":"Department of Machine Learning and Systems Biology, Max Planck Institute of Biochemistry , Martinsried 82152,","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Munich Center for Machine Learning , Munich, 80538,","institution_ids":["https://openalex.org/I292141241"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28290843","https://openalex.org/I292141241","https://openalex.org/I4210150093"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30581439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.14560000598430634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.5040000081062317},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.47999998927116394},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.3937000036239624}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5843999981880188},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5040000081062317},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.47999998927116394},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4009999930858612},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2964000105857849},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2754000127315521},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2547000050544739},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.23250000178813934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23029999434947968}],"mesh":[{"descriptor_ui":"D000096482","descriptor_name":"Angiogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096482","descriptor_name":"Angiogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096482","descriptor_name":"Angiogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btag065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag065","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41818692","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41818692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13008326","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13008326/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btag065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag065","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6432626247406006}],"awards":[{"id":"https://openalex.org/G1132496359","display_name":"Application driven Topological Data Analysis","funder_award_id":"EP/R018472/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2825170161","display_name":"Computational topology and geometry for systems biology","funder_award_id":"EP/Z531224/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6413567830","display_name":null,"funder_award_id":"UF150238","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G6834831930","display_name":"Mathematical Foundations of Intelligence: An "Erlangen Programme" for AI","funder_award_id":"EP/Y028872/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7581437080","display_name":null,"funder_award_id":"RGF\\EA\\201074","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1946356339","https://openalex.org/W1982246723","https://openalex.org/W1991566301","https://openalex.org/W2007105977","https://openalex.org/W2007340184","https://openalex.org/W2022540958","https://openalex.org/W2040296907","https://openalex.org/W2043416386","https://openalex.org/W2044979535","https://openalex.org/W2048195900","https://openalex.org/W2068072750","https://openalex.org/W2102113729","https://openalex.org/W2115445832","https://openalex.org/W2117692326","https://openalex.org/W2123368367","https://openalex.org/W2135267747","https://openalex.org/W2144044408","https://openalex.org/W2146620998","https://openalex.org/W2167116477","https://openalex.org/W2494636976","https://openalex.org/W2573890585","https://openalex.org/W2911964244","https://openalex.org/W2920851774","https://openalex.org/W2963218043","https://openalex.org/W2995700079","https://openalex.org/W3098455240","https://openalex.org/W3118794388","https://openalex.org/W3122042076","https://openalex.org/W3142622887","https://openalex.org/W3167698219","https://openalex.org/W4206116286","https://openalex.org/W4213167815","https://openalex.org/W4251358505","https://openalex.org/W4386275867","https://openalex.org/W4389143060","https://openalex.org/W4401806474","https://openalex.org/W4402599644","https://openalex.org/W4410019444"],"related_works":[],"abstract_inverted_index":{"MOTIVATION:":[0],"Comparing":[1],"mathematical":[2],"models":[3,24,58,106,116],"offers":[4],"a":[5,34,69],"means":[6],"to":[7,21,56,94],"evaluate":[8],"competing":[9],"scientific":[10],"theories.":[11],"However,":[12],"exact":[13],"methods":[14],"of":[15,107],"model":[16,42,76,98,121,138],"calibration":[17],"are":[18],"not":[19],"applicable":[20],"many":[22],"probabilistic":[23],"which":[25,59,87],"simulate":[26,60],"high-dimensional":[27],"spatio-temporal":[28,79,89],"data.":[29],"Approximate":[30],"Bayesian":[31],"Computation":[32],"is":[33,140],"widely":[35],"used":[36],"method":[37],"for":[38,72,130],"parameter":[39,73,96,135],"inference":[40,74,136],"and":[41,47,75,91,97,117,137,145],"selection":[43,77,139],"in":[44,78,113,122],"such":[45],"scenarios,":[46],"it":[48],"may":[49],"be":[50],"combined":[51],"with":[52,62],"Topological":[53],"Data":[54],"Analysis":[55],"study":[57],"data":[61,90,133],"fine":[63],"spatial":[64],"structure.":[65],"RESULTS:":[66],"We":[67,101],"develop":[68],"flexible":[70],"pipeline":[71,82,104],"models.":[80],"Our":[81],"identifies":[83],"topological":[84],"summary":[85],"statistics":[86],"quantify":[88],"uses":[92],"them":[93],"approximate":[95],"posterior":[99],"distributions.":[100],"validate":[102],"our":[103],"on":[105],"tumour-induced":[108],"angiogenesis,":[109],"inferring":[110],"four":[111],"parameters":[112],"three":[114],"established":[115],"identifying":[118],"the":[119],"correct":[120],"synthetic":[123],"test-cases.":[124],"AVAILABILITY":[125],"AND":[126],"IMPLEMENTATION:":[127],"Simulation":[128],"code":[129],"all":[131],"models,":[132],"analyses,":[134],"available":[141],"online":[142],"at":[143,147],"https://github.com/rmcdomaths/tms/":[144],"archived":[146],"https://doi.org/10.5281/zenodo.17392787.":[148]},"counts_by_year":[],"updated_date":"2026-07-12T07:33:03.550515","created_date":"2026-01-29T00:00:00"}