{"id":"https://openalex.org/W7125486061","doi":"https://doi.org/10.1093/bioinformatics/btag032","title":"SAIGE-GPU: accelerating genome- and phenome-wide association studies using GPUs","display_name":"SAIGE-GPU: accelerating genome- and phenome-wide association studies using GPUs","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7125486061","doi":"https://doi.org/10.1093/bioinformatics/btag032","pmid":"https://pubmed.ncbi.nlm.nih.gov/41572430"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btag032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag032","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btag032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123677929","display_name":"Alex Rodriguez","orcid":null},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex Rodriguez","raw_affiliation_strings":["Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,"],"raw_orcid":"https://orcid.org/0000-0003-0723-665X","affiliations":[{"raw_affiliation_string":"Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123671070","display_name":"Youngdae Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngdae Kim","raw_affiliation_strings":["Department of Industrial Engineering, Artificial Intelligence Graduate School, Ulsan National Institute of Science and Technology , Ulsan 44919,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, Artificial Intelligence Graduate School, Ulsan National Institute of Science and Technology , Ulsan 44919,","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120692775","display_name":"Tarak Nath Nandi","orcid":null},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarak Nath Nandi","raw_affiliation_strings":["Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123664074","display_name":"Karl Keat","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Keat","raw_affiliation_strings":["Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113391770","display_name":"Rachit Kumar","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachit Kumar","raw_affiliation_strings":["Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":"https://orcid.org/0000-0002-7736-3307","affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050094627","display_name":"Mitchell Conery","orcid":"https://orcid.org/0000-0001-7640-0797"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210125521","display_name":"Translational Therapeutics (United States)","ror":"https://ror.org/02z3rcy16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Conery","raw_affiliation_strings":["Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,","Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210125521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092832220","display_name":"Rohan Bhukar","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohan Bhukar","raw_affiliation_strings":["Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114,","Program in Medical and Population Genetics , Cambridge, MA 02142,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics , Cambridge, MA 02142,","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000308638","display_name":"Molei Liu","orcid":"https://orcid.org/0000-0003-1890-4449"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molei Liu","raw_affiliation_strings":["Department of Biostatistics, Columbia University\u2019s Mailman School of Public Health , New York, NY 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Columbia University\u2019s Mailman School of Public Health , New York, NY 10032,","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098820900","display_name":"John Hessington","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I922845939","display_name":"Philadelphia University","ror":"https://ror.org/03zzmyz63","country_code":"US","type":"education","lineage":["https://openalex.org/I922845939"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hessington","raw_affiliation_strings":["Information Systems, University of Pennsylvania , Philadelphia, PA 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Systems, University of Pennsylvania , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946","https://openalex.org/I922845939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123641421","display_name":"Ketan Maheshwari","orcid":null},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ketan Maheshwari","raw_affiliation_strings":["Oak Ridge National Laboratory , Oak Ridge, TN 37830,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory , Oak Ridge, TN 37830,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"VA Million Veteran Program","orcid":null},"institutions":[{"id":"https://openalex.org/I1312486979","display_name":"Local Initiatives Support Corporation","ror":"https://ror.org/04r5g1376","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1312486979"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"VA Million Veteran Program","raw_affiliation_strings":["See Supplement for a List of MVP Contributors"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"See Supplement for a List of MVP Contributors","institution_ids":["https://openalex.org/I1312486979"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sumitra Muralidhar","orcid":null},"institutions":[{"id":"https://openalex.org/I2801987317","display_name":"VA Office of Research and Development","ror":"https://ror.org/011qyt180","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801987317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumitra Muralidhar","raw_affiliation_strings":["Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,","institution_ids":["https://openalex.org/I2801987317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Moser","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Moser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer E Deen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer E Deen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Philip S Tsao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip S Tsao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sumitra Muralidhar","orcid":null},"institutions":[{"id":"https://openalex.org/I2801987317","display_name":"VA Office of Research and Development","ror":"https://ror.org/011qyt180","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801987317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumitra Muralidhar","raw_affiliation_strings":["Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,","institution_ids":["https://openalex.org/I2801987317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123692817","display_name":"J Michael Gaziano","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Michael Gaziano","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth Hauser","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Hauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Kilbourne","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Kilbourne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Matheny","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Matheny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dave Oslin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dave Oslin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Michael Gaziano","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Michael Gaziano","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jessica V Brewer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica V Brewer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mary T Brophy","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary T Brophy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly Cho","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Cho","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lori Churby","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori Churby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Scott L DuVall","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott L DuVall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Saiju Pyarajan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saiju Pyarajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Luis E Selva","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis E Selva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shahpoor (Alex) Shayan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahpoor (Alex) Shayan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Stacey B Whitbourne","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey B Whitbourne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Michael Gaziano","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Michael Gaziano","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brady Stephens","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brady Stephens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Todd Connor","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Themistocles L Assimes","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Themistocles L Assimes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Adriana Hung","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Hung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Henry Kranzler","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Kranzler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Samuel Aguayo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Aguayo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sunil Ahuja","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunil Ahuja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kathrina Alexander","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathrina Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao M Androulakis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao M Androulakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Prakash Balasubramanian","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prakash Balasubramanian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zuhair Ballas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuhair Ballas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth S Bast","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth S Bast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jean Beckham","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Beckham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sujata Bhushan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujata Bhushan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Edward Boyko","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward Boyko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Cohen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Louis Dellitalia","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis Dellitalia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gerald Wayne Dryden","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald Wayne Dryden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Christine Faulk","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Christine Faulk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph Fayad","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Fayad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daryl Fujii","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daryl Fujii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Saib Gappy","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saib Gappy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Frank Gesek","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Gesek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Godschalk","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Godschalk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Greco","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Greco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Todd W Gress","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd W Gress","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Samir Gupta","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samir Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Salvador Gutierrez","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvador Gutierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Hamner","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Hamner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Harley","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Harley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel J Hogan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J Hogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Adriana Hung","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Hung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robin Hurley","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin Hurley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Pran Iruvanti","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pran Iruvanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Frank Jacono","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Jacono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Darshana Jhala","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darshana Jhala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Seema Joshi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seema Joshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Scott Kinlay","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Kinlay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Landry","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Landry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Liang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Suthat Liangpunsakul","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suthat Liangpunsakul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jack Lichy","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Lichy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tze Shien Lo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tze Shien Lo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Scott Mahan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Scott Mahan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ronnie Marrache","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronnie Marrache","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen Mastorides","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Mastorides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kristin Mattocks","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin Mattocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Meyer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Meyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jonathan Moorman","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Moorman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Providencia Morales","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Providencia Morales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Timothy Morgan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Maureen Murdoch","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maureen Murdoch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Eknath Naik","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eknath Naik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"James Norton","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Norton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Olaoluwa Okusaga","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olaoluwa Okusaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael K Ong","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael K Ong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kris Ann Oursler","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kris Ann Oursler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ismene Petrakis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ismene Petrakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Samuel Poon","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Poon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amneet S Rai","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amneet S Rai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Rauchman","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Rauchman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Servatius","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Servatius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Satish Sharma","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satish Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"River Smith","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"River Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Peruvemba Sriram","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peruvemba Sriram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Patrick Strollo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Strollo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Neeraj Tandon","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neeraj Tandon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Tsao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Tsao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gerardo Villareal","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerardo Villareal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jessica Walsh","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Wells","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Wells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jeffrey Whittle","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Whittle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mary Whooley","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Whooley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Wilson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Junzhe Xu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junzhe Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shing Shing Yeh","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shing Shing Yeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew W Yen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew W Yen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Edmon Begoli","orcid":null},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmon Begoli","raw_affiliation_strings":["Oak Ridge National Laboratory , Oak Ridge, TN 37830,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory , Oak Ridge, TN 37830,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Georgia Tourassi","orcid":null},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia Tourassi","raw_affiliation_strings":["Computing and Computational Sciences Directorate, Oak Ridge National Laboratory , Oak Ridge, TN 37830,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computing and Computational Sciences Directorate, Oak Ridge National Laboratory , Oak Ridge, TN 37830,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sumitra Muralidhar","orcid":null},"institutions":[{"id":"https://openalex.org/I2801987317","display_name":"VA Office of Research and Development","ror":"https://ror.org/011qyt180","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801987317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumitra Muralidhar","raw_affiliation_strings":["Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs, Office of Research and Development , Washington, DC 20420,","institution_ids":["https://openalex.org/I2801987317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pradeep Natarajan","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep Natarajan","raw_affiliation_strings":["Cardiology Division, Massachusetts General Hospital , Boston, MA 02114,","Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114,","Department of Medicine, Harvard Medical School , Boston, MA 02115,","Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT , Cambridge, MA 02142,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital , Boston, MA 02114,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT , Cambridge, MA 02142,","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benjamin F Voight","orcid":"https://orcid.org/0000-0002-6205-9994"},"institutions":[{"id":"https://openalex.org/I4210125521","display_name":"Translational Therapeutics (United States)","ror":"https://ror.org/02z3rcy16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125521"]},{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin F Voight","raw_affiliation_strings":["Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","Department of Genetics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","Institute for Translational Medicine and Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":"https://orcid.org/0000-0002-6205-9994","affiliations":[{"raw_affiliation_string":"Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210125521"]},{"raw_affiliation_string":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210125521"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kelly Cho","orcid":"https://orcid.org/0000-0003-1727-7076"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Cho","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":"https://orcid.org/0000-0003-1727-7076","affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Michael Gaziano","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Michael Gaziano","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"MVP Boston Coordinating Center, VA Boston Healthcare System , Boston, MA 02111,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Scott M Damrauer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M Damrauer","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","Department of Genetics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","Department of Surgery, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Surgery, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katherine P Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine P Liao","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School , Boston, MA 02115,","Department of Medicine, Harvard Medical School , Boston, MA 02115,","Division of Rheumatology, Department of Medicine, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA 02115,","Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System , Boston, MA 02130,","Medicine, Rheumatology, VA Boston Healthcare System , Boston, MA 02130,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Inflammation, and Immunity, Brigham and Women\u2019s Hospital , Boston, MA 02115,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System , Boston, MA 02130,","institution_ids":["https://openalex.org/I2801671727"]},{"raw_affiliation_string":"Medicine, Rheumatology, VA Boston Healthcare System , Boston, MA 02130,","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128149411","display_name":"Wei Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I2802554885","display_name":"Stanley Foundation","ror":"https://ror.org/035sqd961","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802554885"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02114,","Program in Medical and Population Genetics , Cambridge, MA 02142,","Stanley Center for Psychiatric Research , Cambridge, MA 02142,"],"raw_orcid":"https://orcid.org/0000-0001-7719-0859","affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02114,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics , Cambridge, MA 02142,","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research , Cambridge, MA 02142,","institution_ids":["https://openalex.org/I2802554885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011940218","display_name":"Jennifer E. Huffman","orcid":"https://orcid.org/0000-0002-9672-2491"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210089390","display_name":"Palo Alto Veterans Institute for Research","ror":"https://ror.org/008e03r59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210089390","https://openalex.org/I4210125474"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E Huffman","raw_affiliation_strings":["Department of Medicine, Harvard Medical School , Boston, MA 02115,","Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System , Boston, MA 02130,","Palo Alto Veterans Institute for Research (PAVIR), Palo Alto Health Care System , Palo Alto, CA 94304,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System , Boston, MA 02130,","institution_ids":["https://openalex.org/I2801671727"]},{"raw_affiliation_string":"Palo Alto Veterans Institute for Research (PAVIR), Palo Alto Health Care System , Palo Alto, CA 94304,","institution_ids":["https://openalex.org/I4210089390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128203900","display_name":"Anurag Verma","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125521","display_name":"Translational Therapeutics (United States)","ror":"https://ror.org/02z3rcy16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125521"]},{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anurag Verma","raw_affiliation_strings":["Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corporal Michael Crescenz VA Medical Center , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I4210125521","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania \u2013 Perelman School of Medicine , Philadelphia, PA 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ravi K Madduri","orcid":null},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi K Madduri","raw_affiliation_strings":["Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science and Learning, Argonne National Laboratory , Lemont, IL 60439,","institution_ids":["https://openalex.org/I1282105669"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5123677929"],"corresponding_institution_ids":["https://openalex.org/I1282105669"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10927318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5266000032424927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5266000032424927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1923000067472458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.58160001039505},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4997999966144562},{"id":"https://openalex.org/keywords/data-association","display_name":"Data association","score":0.42910000681877136},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.33469998836517334},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.2946000099182129}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7520999908447266},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.58160001039505},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C2983325608","wikidata":"https://www.wikidata.org/wiki/Q17084606","display_name":"Data association","level":3,"score":0.42910000681877136},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.357699990272522},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.32359999418258667},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.30970001220703125},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.28700000047683716},{"id":"https://openalex.org/C2984499602","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Computer software","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C2984968299","wikidata":"https://www.wikidata.org/wiki/Q1077784","display_name":"Software tool","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C193524817","wikidata":"https://www.wikidata.org/wiki/Q386780","display_name":"Association rule learning","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000080444","descriptor_name":"Phenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000080444","descriptor_name":"Phenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000080444","descriptor_name":"Phenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btag032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag032","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41572430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41572430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12960912","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12960912/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12960912/pdf/btag032.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/56850","is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/56850","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publisher","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btag032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag032","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G104208513","display_name":null,"funder_award_id":"CX001737","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1489425746","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1554891411","display_name":null,"funder_award_id":"IK2-CX001780","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1645119126","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2020449397","display_name":null,"funder_award_id":"MVP000","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G2065692638","display_name":null,"funder_award_id":"VA118-16-M-1062","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2246695849","display_name":null,"funder_award_id":"RS-2020-II201336","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G2294108116","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2661831349","display_name":null,"funder_award_id":"R01AG065582","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G2699521958","display_name":null,"funder_award_id":"RS-2025-00520902","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2924140200","display_name":null,"funder_award_id":"I01CX001849","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3202254208","display_name":null,"funder_award_id":"BX005831","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3507337008","display_name":null,"funder_award_id":"BX004189","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G36973146","display_name":null,"funder_award_id":"RS-2020-II201336","funder_id":"https://openalex.org/F4320335489","funder_display_name":"Institute for Information and Communications Technology Promotion"},{"id":"https://openalex.org/G3873327335","display_name":null,"funder_award_id":"R01GM138597","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4423657506","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320338287","funder_display_name":"Oak Ridge National Laboratory"},{"id":"https://openalex.org/G4538986684","display_name":null,"funder_award_id":"I01CX001849-01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4828869895","display_name":null,"funder_award_id":"MVP000","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5419808090","display_name":null,"funder_award_id":"K08MH122911","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G5946272055","display_name":null,"funder_award_id":"DK126194","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6751399452","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G675320460","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320338287","funder_display_name":"Oak Ridge National Laboratory"},{"id":"https://openalex.org/G6901250098","display_name":null,"funder_award_id":"R01AG067025","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G7734004253","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7995982022","display_name":null,"funder_award_id":"DE-AC05","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8269158468","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G8271222709","display_name":null,"funder_award_id":"BX004821","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8906985441","display_name":null,"funder_award_id":"00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321348","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320335489","display_name":"Institute for Information and Communications Technology Promotion","ror":"https://ror.org/01g0hqq23"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320338287","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1911952697","https://openalex.org/W1966775465","https://openalex.org/W2027867013","https://openalex.org/W2047714674","https://openalex.org/W2049361783","https://openalex.org/W2078129874","https://openalex.org/W2082704080","https://openalex.org/W2098143048","https://openalex.org/W2099085143","https://openalex.org/W2791246728","https://openalex.org/W2950099124","https://openalex.org/W3162800482","https://openalex.org/W3195285310","https://openalex.org/W3202209876","https://openalex.org/W4310375294","https://openalex.org/W4317390883","https://openalex.org/W4318677400","https://openalex.org/W4391925485","https://openalex.org/W4400770247","https://openalex.org/W4414335793"],"related_works":[],"abstract_inverted_index":{"MOTIVATION:":[0],"Genome-wide":[1],"association":[2,39,115],"studies":[3,40],"(GWAS)":[4],"at":[5,149,156],"biobank":[6],"scale":[7],"are":[8,145],"computationally":[9],"intensive,":[10],"especially":[11],"for":[12,25,42,147,158,169],"admixed":[13,93],"populations":[14],"requiring":[15],"robust":[16],"statistical":[17],"models.":[18],"SAIGE":[19,54],"is":[20,31,66,154,163,177],"a":[21,50,97,166],"widely":[22],"used":[23],"method":[24,131],"generalized":[26],"linear":[27],"mixed-model":[28],"GWAS":[29],"but":[30],"limited":[32],"by":[33],"its":[34],"CPU-based":[35],"implementation,":[36],"making":[37],"phenome-wide":[38],"impractical":[41],"many":[43],"research":[44],"groups.":[45],"RESULTS:":[46],"We":[47,110],"developed":[48],"SAIGE-GPU,":[49],"GPU-accelerated":[51],"version":[52],"of":[53],"that":[55],"replaces":[56],"CPU-intensive":[57],"matrix":[58,70],"operations":[59],"with":[60],"GPU-optimized":[61],"kernels.":[62],"The":[63],"core":[64],"innovation":[65],"distributing":[67],"genetic":[68],"relationship":[69],"calculations":[71],"across":[72,171],"GPUs":[73],"and":[74,92,107,120,128,135,143,173,176,181],"communication":[75],"layers.":[76],"Applied":[77],"to":[78],"2068":[79],"phenotypes":[80],"from":[81],"635":[82],"969":[83],"participants":[84],"in":[85,100,165,179],"the":[86,113,130],"Million":[87],"Veteran":[88],"Program,":[89],"including":[90],"diverse":[91],"populations,":[94],"SAIGE-GPU":[95,162],"achieved":[96],"5-fold":[98],"speedup":[99],"mixed":[101],"model":[102],"fitting":[103],"on":[104,124,183],"supercomputing":[105],"infrastructure":[106],"cloud":[108,174],"platforms.":[109],"further":[111],"optimized":[112],"variant":[114],"testing":[116],"step":[117],"through":[118],"multi-core":[119],"multi-trait":[121],"parallelization.":[122],"Deployed":[123],"Google":[125],"Cloud":[126],"Platform":[127],"Azure,":[129],"provided":[132],"substantial":[133],"cost":[134],"time":[136],"savings.":[137],"AVAILABILITY":[138],"AND":[139],"IMPLEMENTATION:":[140],"Source":[141],"code":[142,152],"binaries":[144],"available":[146,164],"download":[148],"https://github.com/saigegit/SAIGE/tree/SAIGE-GPU-1.3.3.":[150],"A":[151],"snapshot":[153],"archived":[155],"Zenodo":[157],"reproducibility":[159],"(DOI:":[160],"[10.5281/zenodo.17642591]).":[161],"containerized":[167],"format":[168],"use":[170],"HPC":[172],"environments":[175],"implemented":[178],"R/C++":[180],"runs":[182],"Linux":[184],"systems.":[185]},"counts_by_year":[],"updated_date":"2026-06-29T08:53:18.405633","created_date":"2026-01-24T00:00:00"}
