{"id":"https://openalex.org/W7119073765","doi":"https://doi.org/10.1093/bioinformatics/btaf688","title":"ASTRO: Automated Spatial-Transcriptome whole RNA Output","display_name":"ASTRO: Automated Spatial-Transcriptome whole RNA Output","publication_year":2026,"publication_date":"2026-01-02","ids":{"openalex":"https://openalex.org/W7119073765","doi":"https://doi.org/10.1093/bioinformatics/btaf688","pmid":"https://pubmed.ncbi.nlm.nih.gov/41495477"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf688","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btaf688","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025441725","display_name":"Dingyao Zhang","orcid":"https://orcid.org/0000-0001-9273-7824"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dingyao Zhang","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine , New Haven, CT 06520,","Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112906132","display_name":"Zhiyuan Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Chu","raw_affiliation_strings":["Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107329737","display_name":"Y Huo","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210117499","display_name":"Yale New Haven Health System","ror":"https://ror.org/01s1hsq14","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiran Huo","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , New Haven, CT 06520,","institution_ids":["https://openalex.org/I4210117499","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024472996","display_name":"Yunzhe Jiang","orcid":"https://orcid.org/0000-0001-8768-0050"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunzhe Jiang","raw_affiliation_strings":["Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073357085","display_name":"Yuhang Chen","orcid":"https://orcid.org/0000-0001-9906-4108"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhang Chen","raw_affiliation_strings":["Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023576301","display_name":"Zhiliang Bai","orcid":"https://orcid.org/0000-0002-3977-3057"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiliang Bai","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University , New Haven, CT 06520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109030844","display_name":"R F Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rong Fan","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University , New Haven, CT 06520,","Department of Pathology, Yale School of Medicine , New Haven, CT 06520,","Human and Translational Immunology, Yale School of Medicine , New Haven, CT 06520,","Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,","Yale Stem Cell Center, Yale School of Medicine , New Haven, CT 06520,"],"raw_orcid":"https://orcid.org/0000-0001-7805-8059","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Human and Translational Immunology, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I2802730090"]},{"raw_affiliation_string":"Yale Stem Cell Center, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122111740","display_name":"Jun Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Lu","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine , New Haven, CT 06520,","Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,","Yale Cooperative Center of Excellence in Hematology, Yale School of Medicine , New Haven, CT 06520,","Yale Stem Cell Center, Yale School of Medicine , New Haven, CT 06520,"],"raw_orcid":"https://orcid.org/0000-0003-2726-7613","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I2802730090"]},{"raw_affiliation_string":"Yale Cooperative Center of Excellence in Hematology, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Stem Cell Center, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I2802730090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008781578","display_name":"M. Gerstein","orcid":null},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Gerstein","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University , New Haven, CT 06520,","Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,"],"raw_orcid":"https://orcid.org/0000-0002-9746-3719","affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Program in Computational Biology and Bioinformatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center and Yale Center for RNA Science and Medicine, Yale School of Medicine , New Haven, CT 06520,","institution_ids":["https://openalex.org/I2802730090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008781578","https://openalex.org/A5023576301","https://openalex.org/A5109030844","https://openalex.org/A5122111740"],"corresponding_institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02886212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.22010000050067902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.43700000643730164},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.4332999885082245},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.41990000009536743},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.32409998774528503},{"id":"https://openalex.org/keywords/automated-method","display_name":"Automated method","score":0.26840001344680786}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6434000134468079},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.444599986076355},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4332999885082245},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.32409998774528503},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2587999999523163}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf688","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41495477","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41495477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:11673985","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12866646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf688","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2017426710","https://openalex.org/W2036897871","https://openalex.org/W2069114336","https://openalex.org/W2108234281","https://openalex.org/W2136430672","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2223836536","https://openalex.org/W2288482887","https://openalex.org/W2604408404","https://openalex.org/W2804460316","https://openalex.org/W2898731714","https://openalex.org/W3036371598","https://openalex.org/W3095979265","https://openalex.org/W3100967665","https://openalex.org/W3115880421","https://openalex.org/W4200454931","https://openalex.org/W4210840193","https://openalex.org/W4283691112","https://openalex.org/W4291286390","https://openalex.org/W4308045236","https://openalex.org/W4308948108","https://openalex.org/W4313488537","https://openalex.org/W4379521442","https://openalex.org/W4382247041","https://openalex.org/W4383340946","https://openalex.org/W4385515928","https://openalex.org/W4390002724","https://openalex.org/W4390691625","https://openalex.org/W4400900810","https://openalex.org/W4402966611","https://openalex.org/W4404369323","https://openalex.org/W4404535307"],"related_works":[],"abstract_inverted_index":{"MOTIVATION:":[0],"Despite":[1],"significant":[2,34],"advances":[3],"in":[4,29,67,119,149,157],"spatial":[5,31,56,81,130],"transcriptomics,":[6],"the":[7,49,100,115,134,150],"analysis":[8,66],"of":[9,96,102],"formalin-fixed":[10],"paraffin-embedded":[11],"(FFPE)":[12],"tissues,":[13,121],"which":[14],"constitute":[15],"most":[16],"clinically":[17],"available":[18,165],"samples,":[19,98],"remains":[20],"challenging.":[21],"Additionally,":[22],"capturing":[23],"both":[24],"coding":[25,144],"and":[26,54,128,145,153,169],"non-coding":[27,107,146],"RNAs":[28,108],"a":[30,40,124],"context":[32],"poses":[33],"challenges.":[35],"We":[36],"recently":[37],"introduced":[38],"Patho-DBiT,":[39],"technology":[41],"designed":[42],"to":[43,79,86,141],"address":[44],"these":[45],"unmet":[46],"needs.":[47],"However,":[48],"marked":[50],"differences":[51],"between":[52],"Patho-DBiT":[53],"existing":[55],"transcriptomics":[57,82],"protocols":[58],"necessitate":[59],"specialized":[60,125],"computational":[61],"tools":[62],"for":[63,93,114],"comprehensive":[64],"whole-transcriptome":[65,94],"FFPE":[68,97,120,158],"samples.":[69,159],"RESULTS:":[70],"Here,":[71],"we":[72],"present":[73],"ASTRO,":[74],"an":[75],"automated":[76],"pipeline":[77],"developed":[78],"process":[80],"data.":[83],"In":[84],"addition":[85],"supporting":[87],"standard":[88],"datasets,":[89],"ASTRO":[90,122,140],"is":[91],"optimized":[92],"analyses":[95],"enabling":[99],"detection":[101],"various":[103],"RNA":[104,117,147],"species,":[105],"including":[106],"such":[109],"as":[110],"miRNAs.":[111],"To":[112],"compensate":[113],"reduced":[116],"quality":[118],"incorporates":[123],"filtering":[126],"step":[127],"optimizes":[129],"barcode":[131],"calling,":[132],"increasing":[133],"mapping":[135],"rate.":[136],"These":[137],"optimizations":[138],"allow":[139],"spatially":[142],"quantify":[143],"species":[148],"entire":[151],"transcriptome":[152],"achieve":[154],"robust":[155],"performance":[156],"AVAILABILITY":[160],"AND":[161],"IMPLEMENTATION:":[162],"Codes":[163],"are":[164],"at":[166],"GitHub":[167],"(https://github.com/gersteinlab/ASTRO)":[168],"Zenodo":[170],"(doi:":[171],"10.5281/zenodo.17913760).":[172]},"counts_by_year":[],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2026-01-08T00:00:00"}
