{"id":"https://openalex.org/W4415536672","doi":"https://doi.org/10.1093/bioinformatics/btaf581","title":"Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data","display_name":"Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415536672","doi":"https://doi.org/10.1093/bioinformatics/btaf581","pmid":"https://pubmed.ncbi.nlm.nih.gov/41131798"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf581","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btaf581","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019196444","display_name":"Jiajun Gu","orcid":"https://orcid.org/0000-0003-3336-6984"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junhao Gu","raw_affiliation_strings":["University of California, Irvine Department of Chemical & Biomolecular Engineering, , Irvine, CA, 92617,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","NSF Simons Center for Multiscale Cell Fate, United States","Dept. of Chemical & Biomolecular Engineering, University of California, Irvine, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Chemical & Biomolecular Engineering, , Irvine, CA, 92617,","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]},{"raw_affiliation_string":"Dept. of Chemical & Biomolecular Engineering, University of California, Irvine, United States","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116589989","display_name":"Nandor Laszik","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nandor Laszik","raw_affiliation_strings":["University of California, Irvine Department of Biomedical Engineering, , Irvine, CA, 92697,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","NSF Simons Center for Multiscale Cell Fate, United States","Dept. of Biomedical Engineering, University of California, Irvine, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Biomedical Engineering, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, University of California, Irvine, United States","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210140791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036077055","display_name":"Christopher E. Miles","orcid":"https://orcid.org/0000-0001-5494-403X"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher E Miles","raw_affiliation_strings":["University of California, Irvine Department of Mathematics, , Irvine, CA, 92697,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","Dept. of Mathematics, University of California, Irvine, United States","NSF Simons Center for Multiscale Cell Fate, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Mathematics, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210140791"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Dept. of Mathematics, University of California, Irvine, United States","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210140791"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075874996","display_name":"Jun Allard","orcid":"https://orcid.org/0000-0002-2758-4515"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Allard","raw_affiliation_strings":["University of California, Irvine Department of Mathematics, , Irvine, CA, 92697,","University of California, Irvine Department of Physics, , Irvine, CA, 92697,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","Dept. of Physics, University of California, Irvine, United States","NSF Simons Center for Multiscale Cell Fate, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Mathematics, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210140791"]},{"raw_affiliation_string":"University of California, Irvine Department of Physics, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Dept. of Physics, University of California, Irvine, United States","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016155920","display_name":"Timothy L. Downing","orcid":"https://orcid.org/0000-0002-5197-3684"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy L Downing","raw_affiliation_strings":["University of California, Irvine Department of Biomedical Engineering, , Irvine, CA, 92697,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","Dept. of Biomedical Engineering, University of California, Irvine, United States","NSF Simons Center for Multiscale Cell Fate, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Biomedical Engineering, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, University of California, Irvine, United States","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210140791"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046882565","display_name":"Elizabeth L. Read","orcid":"https://orcid.org/0000-0002-9186-284X"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210107338","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338"]},{"id":"https://openalex.org/I4210140791","display_name":"Irvine University","ror":"https://ror.org/04ysmca02","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth L Read","raw_affiliation_strings":["University of California, Irvine Department of Chemical & Biomolecular Engineering, , Irvine, CA, 92617,","University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","Dept. of Chemical & Biomolecular Engineering, University of California, Irvine, United States","NSF Simons Center for Multiscale Cell Fate, United States"],"affiliations":[{"raw_affiliation_string":"University of California, Irvine Department of Chemical & Biomolecular Engineering, , Irvine, CA, 92617,","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine NSF Simons Center for Multiscale Cell Fate, , Irvine, CA, 92697,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Dept. of Chemical & Biomolecular Engineering, University of California, Irvine, United States","institution_ids":["https://openalex.org/I4210140791","https://openalex.org/I204250578"]},{"raw_affiliation_string":"NSF Simons Center for Multiscale Cell Fate, United States","institution_ids":["https://openalex.org/I4210107338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019196444"],"corresponding_institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210107338","https://openalex.org/I4210140791"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.534,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.85048581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"41","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.7720000147819519},{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.7508999705314636},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.6656000018119812},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.635200023651123},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.5041000247001648},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.43309998512268066},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.7720000147819519},{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.7508999705314636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6711000204086304},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.6656000018119812},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.635200023651123},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5264000296592712},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.5041000247001648},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.43309998512268066},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4050999879837036},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3625999987125397},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33559998869895935},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3197999894618988},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29010000824928284},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C86426650","wikidata":"https://www.wikidata.org/wiki/Q7452504","display_name":"Sequential estimation","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C104267543","wikidata":"https://www.wikidata.org/wiki/Q208163","display_name":"Signal processing","level":3,"score":0.2535000145435333},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaf581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf581","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41131798","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41131798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf581","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3205510348","display_name":null,"funder_award_id":"DMS1763272","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8060642315","display_name":null,"funder_award_id":"EF2022182","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G986754019","display_name":null,"funder_award_id":"594598","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1975728537","https://openalex.org/W1984429906","https://openalex.org/W2005361347","https://openalex.org/W2018435536","https://openalex.org/W2019472515","https://openalex.org/W2022959322","https://openalex.org/W2023593061","https://openalex.org/W2058415154","https://openalex.org/W2061658794","https://openalex.org/W2066594542","https://openalex.org/W2072391169","https://openalex.org/W2075251971","https://openalex.org/W2075865654","https://openalex.org/W2080252570","https://openalex.org/W2081970839","https://openalex.org/W2096705138","https://openalex.org/W2106391833","https://openalex.org/W2111167674","https://openalex.org/W2114870653","https://openalex.org/W2116238099","https://openalex.org/W2122864540","https://openalex.org/W2124149894","https://openalex.org/W2128551987","https://openalex.org/W2129375080","https://openalex.org/W2131534552","https://openalex.org/W2132980978","https://openalex.org/W2137088684","https://openalex.org/W2138776564","https://openalex.org/W2141439678","https://openalex.org/W2141688036","https://openalex.org/W2145748272","https://openalex.org/W2156541178","https://openalex.org/W2167244112","https://openalex.org/W2168648059","https://openalex.org/W2171327609","https://openalex.org/W2508567769","https://openalex.org/W2518662817","https://openalex.org/W2766437506","https://openalex.org/W2888658056","https://openalex.org/W2906180136","https://openalex.org/W2909936502","https://openalex.org/W2910801096","https://openalex.org/W2911433402","https://openalex.org/W2949465911","https://openalex.org/W2951506174","https://openalex.org/W2952685709","https://openalex.org/W2977512847","https://openalex.org/W2985077757","https://openalex.org/W3015693380","https://openalex.org/W3033596656","https://openalex.org/W3046663842","https://openalex.org/W3126293391","https://openalex.org/W3185999759","https://openalex.org/W3186637316","https://openalex.org/W3190789861","https://openalex.org/W3206063748","https://openalex.org/W4225981439","https://openalex.org/W4302011891","https://openalex.org/W4306406786","https://openalex.org/W4308055480","https://openalex.org/W4381852036","https://openalex.org/W4387015074","https://openalex.org/W4387168298","https://openalex.org/W4396886318","https://openalex.org/W4401960010","https://openalex.org/W4402758304","https://openalex.org/W4405019659","https://openalex.org/W4408726337","https://openalex.org/W4409251195"],"related_works":[],"abstract_inverted_index":{"All":[0],"code":[1],"relevant":[2],"to":[3],"this":[4],"work":[5],"is":[6],"available":[7],"at":[8],"https://github.com/Read-Lab-UCI/TelegraphLikelihoodInfer,":[9],"archival":[10],"DOI:":[11],"https://doi.org/10.5281/zenodo.16915450.":[12]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-25T00:00:00"}