{"id":"https://openalex.org/W4414624324","doi":"https://doi.org/10.1093/bioinformatics/btaf512","title":"UAMRL: multi-granularity uncertainty-aware multimodal representation learning for drug-target affinity prediction","display_name":"UAMRL: multi-granularity uncertainty-aware multimodal representation learning for drug-target affinity prediction","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4414624324","doi":"https://doi.org/10.1093/bioinformatics/btaf512","pmid":"https://pubmed.ncbi.nlm.nih.gov/41025463"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf512","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf512/64434077/btaf512.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf512/64434077/btaf512.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wenzhe Xu","orcid":"https://orcid.org/0009-0006-6141-4022"},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhe Xu","raw_affiliation_strings":["School of Computer and Software Engineering, Xihua University , Chengdu 610039,","School of Computer and Software Engineering, Xihua University, Chengdu, 610039, China"],"raw_orcid":"https://orcid.org/0009-0006-6141-4022","affiliations":[{"raw_affiliation_string":"School of Computer and Software Engineering, Xihua University , Chengdu 610039,","institution_ids":["https://openalex.org/I102345215"]},{"raw_affiliation_string":"School of Computer and Software Engineering, Xihua University, Chengdu, 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630632","display_name":"Xiaorong Liu","orcid":"https://orcid.org/0000-0002-8912-5066"},"institutions":[{"id":"https://openalex.org/I165745306","display_name":"Southwest Petroleum University","ror":"https://ror.org/03h17x602","country_code":"CN","type":"education","lineage":["https://openalex.org/I165745306"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorong Liu","raw_affiliation_strings":["School of Computer Science and Software Engineering, Southwest Petroleum University , Chengdu 610500,","School of Computer Science and Software Engineering, Southwest petroleum university, Chengdu, 610500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Software Engineering, Southwest Petroleum University , Chengdu 610500,","institution_ids":["https://openalex.org/I165745306"]},{"raw_affiliation_string":"School of Computer Science and Software Engineering, Southwest petroleum university, Chengdu, 610500, China","institution_ids":["https://openalex.org/I165745306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037948280","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0001-6669-8171"},"institutions":[{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wang","raw_affiliation_strings":["School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","School of Design, Southwest Jiaotong University, Chengdu, 611756, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","institution_ids":["https://openalex.org/I4800084"]},{"raw_affiliation_string":"School of Design, Southwest Jiaotong University, Chengdu, 611756, China","institution_ids":["https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403560","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-2319-6133"},"institutions":[{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["School of Design, Southwest Jiaotong University , Chengdu 611756,","School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Design, Southwest Jiaotong University , Chengdu 611756,","institution_ids":["https://openalex.org/I4800084"]},{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, China","institution_ids":["https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102220988","display_name":"Dongfeng Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongfeng Hu","raw_affiliation_strings":["School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","School of Computer and Software Engineering, Xihua University, Chengdu, 610039, China","School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","institution_ids":["https://openalex.org/I4800084"]},{"raw_affiliation_string":"School of Computer and Software Engineering, Xihua University, Chengdu, 610039, China","institution_ids":["https://openalex.org/I102345215"]},{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, China","institution_ids":["https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dongfeng Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongfeng Hu","raw_affiliation_strings":["School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","institution_ids":["https://openalex.org/I4800084"]}]},{"author_position":"last","author":{"id":null,"display_name":"Liansong Zong","orcid":null},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liansong Zong","raw_affiliation_strings":["School of Computer and Software Engineering, Xihua University , Chengdu 610039,","School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer and Software Engineering, Xihua University , Chengdu 610039,","institution_ids":["https://openalex.org/I102345215"]},{"raw_affiliation_string":"School of Computing and Artificial Intelligence, Southwest Jiaotong University , Chengdu 611756,","institution_ids":["https://openalex.org/I4800084"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4800084"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.7361,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77723695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"41","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9728000164031982,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9728000164031982,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5892999768257141},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5782999992370605},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.508899986743927},{"id":"https://openalex.org/keywords/feature-learning","display_name":"Feature learning","score":0.35179999470710754},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3458999991416931}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7860999703407288},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.644599974155426},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5892999768257141},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5782999992370605},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.508899986743927},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.35179999470710754},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33899998664855957},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.28839999437332153},{"id":"https://openalex.org/C2982736386","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Statistical learning","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.2574000060558319}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf512","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf512/64434077/btaf512.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41025463","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41025463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:11360909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12553331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf512","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf512","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf512/64434077/btaf512.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4792181493","display_name":null,"funder_award_id":"2682025CX105","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5158416201","display_name":null,"funder_award_id":"2025M771637","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414624324.pdf","grobid_xml":"https://content.openalex.org/works/W4414624324.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1995875735","https://openalex.org/W2085558649","https://openalex.org/W2092285329","https://openalex.org/W2096864392","https://openalex.org/W2111959010","https://openalex.org/W2116064496","https://openalex.org/W2605952223","https://openalex.org/W2767832667","https://openalex.org/W2781821160","https://openalex.org/W2784213390","https://openalex.org/W2785947426","https://openalex.org/W2809216727","https://openalex.org/W2911546748","https://openalex.org/W2974531988","https://openalex.org/W3019745511","https://openalex.org/W3029836473","https://openalex.org/W3096561213","https://openalex.org/W3109916301","https://openalex.org/W3151148247","https://openalex.org/W4205171481","https://openalex.org/W4294000785","https://openalex.org/W4322745247","https://openalex.org/W4361282512","https://openalex.org/W4380742954","https://openalex.org/W4386084749","https://openalex.org/W4388006581","https://openalex.org/W4400142953","https://openalex.org/W4407852535","https://openalex.org/W4410708109"],"related_works":[],"abstract_inverted_index":{"MOTIVATION:":[0],"Computational":[1],"prediction":[2,123],"of":[3,19,27,98],"drug-target":[4],"affinity":[5],"(DTA)":[6],"plays":[7],"a":[8,45,59,72],"critical":[9],"role":[10],"in":[11,37,71],"modern":[12],"drug":[13,39],"discovery.":[14],"However,":[15],"the":[16,25,89,96],"limited":[17],"interpretability":[18],"traditional":[20],"deep":[21],"learning":[22],"models":[23],"and":[24,32,69,75,101,125],"heterogeneity":[26],"multimodal":[28],"data":[29],"from":[30,79],"compounds":[31],"proteins":[33],"hinder":[34],"their":[35],"reliability":[36,97],"practical":[38],"development":[40],"applications.":[41],"RESULTS:":[42],"We":[43],"propose":[44],"novel":[46],"Uncertainty-aware":[47],"Multimodal":[48],"Representation":[49],"Learning":[50],"(UAMRL)":[51],"framework":[52],"to":[53,62,94],"address":[54],"these":[55],"challenges.":[56],"UAMRL":[57,111],"employs":[58],"dual-stream":[60],"encoder":[61],"learn":[63],"cross-modal":[64],"association":[65],"mappings":[66],"between":[67],"drugs":[68],"targets":[70],"latent":[73],"space":[74],"integrates":[76],"heterogeneous":[77,99],"information":[78,100],"different":[80],"modalities.":[81],"Moreover,":[82],"an":[83],"uncertainty":[84],"quantification":[85],"mechanism":[86],"based":[87],"on":[88,116],"Normal-Inverse-Gamma":[90],"distribution":[91],"is":[92,134],"introduced":[93],"model":[95],"suppress":[102],"less":[103],"trustworthy":[104],"contributions":[105],"during":[106],"fusion.":[107],"Experiments":[108],"show":[109],"that":[110],"achieves":[112],"superior":[113],"predictive":[114],"accuracy":[115],"multiple":[117],"public":[118],"DTA":[119],"datasets,":[120],"improving":[121],"both":[122],"performance":[124],"decision":[126],"transparency.":[127],"AVAILABILITY":[128],"AND":[129],"IMPLEMENTATION:":[130],"The":[131],"source":[132],"code":[133],"available":[135],"at":[136],"https://github.com/Astraea2xu/UAMRL.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}
