{"id":"https://openalex.org/W4412366277","doi":"https://doi.org/10.1093/bioinformatics/btaf398","title":"LegionProfiler: A computational tool for the identification of virulence factors and classification of <i>Legionella pneumophila</i> serogroup 1 isolates","display_name":"LegionProfiler: A computational tool for the identification of virulence factors and classification of <i>Legionella pneumophila</i> serogroup 1 isolates","publication_year":2025,"publication_date":"2025-07-12","ids":{"openalex":"https://openalex.org/W4412366277","doi":"https://doi.org/10.1093/bioinformatics/btaf398","pmid":"https://pubmed.ncbi.nlm.nih.gov/40650928"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf398","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf398","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf398/63735664/btaf398.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf398/63735664/btaf398.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083957020","display_name":"Oluwafemi A. Sarumi","orcid":"https://orcid.org/0000-0001-6463-1029"},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oluwafemi A Sarumi","raw_affiliation_strings":["Albert-Schweitzer-Campus University of M\u00fcnster, Institute of Medical Informatics, , M\u00fcnster, 48149,","Institute of Medical Informatics, University of M\u00fcnster, Albert-Schweitzer-Campus , M\u00fcnster 48149,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert-Schweitzer-Campus University of M\u00fcnster, Institute of Medical Informatics, , M\u00fcnster, 48149,","institution_ids":["https://openalex.org/I4210103666","https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of M\u00fcnster, Albert-Schweitzer-Campus , M\u00fcnster 48149,","institution_ids":["https://openalex.org/I4210103666","https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004098289","display_name":"Wilhelm Bertrams","orcid":"https://orcid.org/0000-0002-0180-2529"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wilhelm Bertrams","raw_affiliation_strings":["Philipps-University Marburg Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg, Marburg, Germany, Core Facility Flow Cytometry\u2014Bacterial Vesicles, , Marburg,","Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg , Marburg 35043,","Core Facility Flow Cytometry \u2013 Bacterial Vesicles, Philipps-University Marburg , Marburg 35043,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philipps-University Marburg Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg, Marburg, Germany, Core Facility Flow Cytometry\u2014Bacterial Vesicles, , Marburg,","institution_ids":["https://openalex.org/I4210131615","https://openalex.org/I161103922"]},{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg , Marburg 35043,","institution_ids":["https://openalex.org/I4210131615"]},{"raw_affiliation_string":"Core Facility Flow Cytometry \u2013 Bacterial Vesicles, Philipps-University Marburg , Marburg 35043,","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082557857","display_name":"Oliver Schwengers","orcid":"https://orcid.org/0000-0003-4216-2721"},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Schwengers","raw_affiliation_strings":["Justus Liebig University Giessen Bioinformatics and Systems Biology, , Giessen 35392,","Bioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen 35392, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Justus Liebig University Giessen Bioinformatics and Systems Biology, , Giessen 35392,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen 35392, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007030319","display_name":"Jan-Paul Herrmann","orcid":null},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan-Paul Herrmann","raw_affiliation_strings":["Justus Liebig University Giessen Institute of Medical Microbiology, , 35392 Giessen,","Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen 35392, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Justus Liebig University Giessen Institute of Medical Microbiology, , 35392 Giessen,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen 35392, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088669496","display_name":"Torsten Hain","orcid":"https://orcid.org/0000-0003-0149-3137"},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Hain","raw_affiliation_strings":["Justus Liebig University Giessen Institute of Medical Microbiology, , 35392 Giessen,","Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen 35392, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Justus Liebig University Giessen Institute of Medical Microbiology, , 35392 Giessen,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen 35392, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117712696","display_name":"Laurine Kieper","orcid":"https://orcid.org/0009-0006-2926-4212"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laurine Kieper","raw_affiliation_strings":["University Hospital Carl Gustav Carus, TUD Dresden University of Technology Institute for Medical Microbiology and Virology, Medical Faculty and , Dresden,","Institute for Medical Microbiology and Virology, Medical Faculty, and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden 01307, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Carl Gustav Carus, TUD Dresden University of Technology Institute for Medical Microbiology and Virology, Medical Faculty and , Dresden,","institution_ids":["https://openalex.org/I4210162051"]},{"raw_affiliation_string":"Institute for Medical Microbiology and Virology, Medical Faculty, and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden 01307, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076756639","display_name":"Markus Petzold","orcid":"https://orcid.org/0000-0001-6622-5550"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Petzold","raw_affiliation_strings":["University Hospital Carl Gustav Carus, TUD Dresden University of Technology Institute for Medical Microbiology and Virology, Medical Faculty and , Dresden,","Institute for Medical Microbiology and Virology, Medical Faculty, and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden 01307, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Carl Gustav Carus, TUD Dresden University of Technology Institute for Medical Microbiology and Virology, Medical Faculty and , Dresden,","institution_ids":["https://openalex.org/I4210162051"]},{"raw_affiliation_string":"Institute for Medical Microbiology and Virology, Medical Faculty, and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden 01307, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088085534","display_name":"Alexander Goesmann","orcid":"https://orcid.org/0000-0002-7086-2568"},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Goesmann","raw_affiliation_strings":["Justus Liebig University Giessen Bioinformatics and Systems Biology, , Giessen 35392,","Bioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen 35392, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Justus Liebig University Giessen Bioinformatics and Systems Biology, , Giessen 35392,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen 35392, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070409333","display_name":"Bernd Schmeck","orcid":"https://orcid.org/0000-0002-2767-3606"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd T Schmeck","raw_affiliation_strings":["Philipps-University Marburg Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg, Marburg, Germany, Core Facility Flow Cytometry\u2014Bacterial Vesicles, , Marburg,","Core Facility Flow Cytometry \u2013 Bacterial Vesicles, Philipps-University Marburg , Marburg 35043,","Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg , Marburg 35043,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philipps-University Marburg Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg, Marburg, Germany, Core Facility Flow Cytometry\u2014Bacterial Vesicles, , Marburg,","institution_ids":["https://openalex.org/I4210131615","https://openalex.org/I161103922"]},{"raw_affiliation_string":"Core Facility Flow Cytometry \u2013 Bacterial Vesicles, Philipps-University Marburg , Marburg 35043,","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universit\u00e4t Marburg , Marburg 35043,","institution_ids":["https://openalex.org/I4210131615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060650201","display_name":"Dominik Heider","orcid":"https://orcid.org/0000-0002-3108-8311"},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Heider","raw_affiliation_strings":["Albert-Schweitzer-Campus University of M\u00fcnster, Institute of Medical Informatics, , M\u00fcnster, 48149,","Institute of Medical Informatics, University of M\u00fcnster, Albert-Schweitzer-Campus , M\u00fcnster 48149,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert-Schweitzer-Campus University of M\u00fcnster, Institute of Medical Informatics, , M\u00fcnster, 48149,","institution_ids":["https://openalex.org/I4210103666","https://openalex.org/I22465464"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of M\u00fcnster, Albert-Schweitzer-Campus , M\u00fcnster 48149,","institution_ids":["https://openalex.org/I4210103666","https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5083957020"],"corresponding_institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13188709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.9769999980926514,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.9769999980926514,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.8646285533905029},{"id":"https://openalex.org/keywords/legionella-pneumophila","display_name":"Legionella pneumophila","score":0.8193947076797485},{"id":"https://openalex.org/keywords/legionella","display_name":"Legionella","score":0.49904537200927734},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.48938077688217163},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4654460847377777},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.4379352331161499},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.3791796863079071},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3551729619503021},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33204174041748047},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.24770957231521606},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.14025431871414185},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10952833294868469},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.08926567435264587},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0715855062007904}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8646285533905029},{"id":"https://openalex.org/C2776118409","wikidata":"https://www.wikidata.org/wiki/Q147885","display_name":"Legionella pneumophila","level":3,"score":0.8193947076797485},{"id":"https://openalex.org/C2779164008","wikidata":"https://www.wikidata.org/wiki/Q158013","display_name":"Legionella","level":3,"score":0.49904537200927734},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.48938077688217163},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4654460847377777},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.4379352331161499},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3791796863079071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3551729619503021},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33204174041748047},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24770957231521606},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.14025431871414185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10952833294868469},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08926567435264587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0715855062007904},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btaf398","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf398","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf398/63735664/btaf398.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40650928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40650928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmid:40726111","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40726111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12304514","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12304514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf398","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf398","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf398/63735664/btaf398.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G7314789148","display_name":null,"funder_award_id":"031L0288A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321721","display_name":"Bundesministerium f\u00fcr Gesundheit","ror":"https://ror.org/05vp4ka74"},{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412366277.pdf","grobid_xml":"https://content.openalex.org/works/W4412366277.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388004154","https://openalex.org/W2096746799","https://openalex.org/W2422057152","https://openalex.org/W2132036669","https://openalex.org/W2767727320","https://openalex.org/W95316288","https://openalex.org/W2042294116","https://openalex.org/W2142946408","https://openalex.org/W1525384498","https://openalex.org/W2812598441"],"abstract_inverted_index":{"SUMMARY:":[0],"Legionella":[1,57],"pneumophila":[2,58],"has":[3],"significantly":[4],"contributed":[5],"to":[6,20,86,101,112],"multiple":[7],"cases":[8],"of":[9,15,56,74,105,116,125],"pneumonia":[10,89],"with":[11],"a":[12,43,98,142,154],"high":[13],"rate":[14],"mortality":[16],"globally.":[17],"Its":[18],"ability":[19],"exploit":[21],"host":[22],"mechanisms":[23],"through":[24,97],"several":[25],"expressed":[26],"virulence":[27,49],"factors":[28],"poses":[29],"challenges":[30],"for":[31,77],"diagnosis,":[32],"treatment,":[33],"and":[34,62,81,108,147],"outbreak":[35],"control.":[36],"To":[37],"address":[38],"this,":[39],"we":[40],"developed":[41],"LegionProfiler,":[42],"computational":[44],"tool":[45],"that":[46,129],"swiftly":[47],"identifies":[48],"factor":[50],"protein":[51,79],"domains":[52,80],"within":[53],"genome":[54,75],"assemblies":[55,76],"serogroup":[59],"1":[60],"isolates":[61],"classifies":[63],"them":[64],"into":[65],"high-":[66],"or":[67,165],"low-virulence":[68],"groups.":[69],"LegionProfiler":[70,92,137],"automates":[71],"the":[72,83,113,123],"probing":[73],"virulence-associated":[78],"determines":[82],"isolate's":[84],"potential":[85],"cause":[87],"severe":[88],"infection.":[90],"The":[91,157],"workflow":[93],"is":[94,138],"made":[95],"available":[96,174],"user-friendly":[99],"interface":[100],"enhance":[102],"technical":[103],"control":[104],"infectious":[106],"sources":[107],"adds":[109],"important":[110],"insights":[111],"general":[114],"epidemiology":[115],"clinical":[117],"isolates.":[118],"It":[119],"could":[120],"also":[121,149],"support":[122],"development":[124],"targeted":[126],"therapeutic":[127],"strategies":[128],"will":[130],"improve":[131],"patient":[132],"treatment.":[133],"AVAILABILITY":[134],"AND":[135],"IMPLEMENTATION:":[136],"freely":[139],"accessible":[140],"as":[141],"web":[143],"service":[144],"at":[145,163,166,175],"https://legionprofiler.uni-muenster.de,":[146],"can":[148,160],"be":[150,161],"run":[151],"locally":[152],"in":[153],"Docker":[155],"container.":[156],"source":[158],"code":[159],"found":[162],"https://imigitlab.uni-muenster.de/heiderlab/legionprofiler":[164],"Zenodo":[167],"(DOI:10.5281/zenodo.15592325).":[168],"SUPPLEMENTARY":[169],"INFORMATION:":[170],"Supplementary":[171],"data":[172],"are":[173],"Bioinformatics":[176],"online.":[177]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-07-12T00:00:00"}