{"id":"https://openalex.org/W4411960244","doi":"https://doi.org/10.1093/bioinformatics/btaf385","title":"Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction","display_name":"Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411960244","doi":"https://doi.org/10.1093/bioinformatics/btaf385","pmid":"https://pubmed.ncbi.nlm.nih.gov/40600900"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf385","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf385/63646110/btaf385.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf385/63646110/btaf385.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061785514","display_name":"Yidong Hou","orcid":"https://orcid.org/0000-0002-6983-3700"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yalin Hou","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346366","display_name":"Yiming Li","orcid":"https://orcid.org/0000-0003-4602-3905"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044328870","display_name":"Ruiqing Zheng","orcid":"https://orcid.org/0000-0001-6372-6798"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiqing Zheng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031936014","display_name":"Fuhao Zhang","orcid":"https://orcid.org/0009-0001-4336-431X"},"institutions":[{"id":"https://openalex.org/I4210088176","display_name":"North West Agriculture and Forestry University","ror":null,"country_code":"CN","type":null,"lineage":["https://openalex.org/I4210088176"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuhao Zhang","raw_affiliation_strings":["College of Information Engineering, Northwest A&F University , Yangling, Shaanxi 712100,","Northwest A&F University College of Information Engineering, , Yangling, Shaanxi 712100,"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Northwest A&F University , Yangling, Shaanxi 712100,","institution_ids":["https://openalex.org/I4210088176"]},{"raw_affiliation_string":"Northwest A&F University College of Information Engineering, , Yangling, Shaanxi 712100,","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112879504","display_name":"Fei Guo","orcid":"https://orcid.org/0000-0002-9279-9547"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Guo","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109862492","display_name":"Min Li","orcid":"https://orcid.org/0000-0003-3518-683X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033885404","display_name":"Min Zeng","orcid":"https://orcid.org/0000-0002-1726-0955"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zeng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha 410083,","Central South University School of Computer Science and Engineering, , Changsha, 410083,"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha 410083,","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Central South University School of Computer Science and Engineering, , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5061785514"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":3.7748,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.93427849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"41","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.9230971336364746},{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.7436280846595764},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.7043768167495728},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.684004545211792},{"id":"https://openalex.org/keywords/subgenomic-mrna","display_name":"Subgenomic mRNA","score":0.46870940923690796},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.45513805747032166},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3949007987976074},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33746662735939026},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19777452945709229},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16204264760017395},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.1549493968486786},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11385178565979004}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.9230971336364746},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.7436280846595764},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.7043768167495728},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.684004545211792},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.46870940923690796},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.45513805747032166},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3949007987976074},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33746662735939026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19777452945709229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16204264760017395},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.1549493968486786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11385178565979004}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf385","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf385/63646110/btaf385.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40600900","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40600900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12254127","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12254127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf385","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf385/63646110/btaf385.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5874166562","display_name":null,"funder_award_id":"2023JJ40763","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6363746905","display_name":null,"funder_award_id":"62472445","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8160189100","display_name":null,"funder_award_id":"2022YFC3400300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8764071032","display_name":null,"funder_award_id":"2022YFC","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321514","display_name":"Central South University","ror":"https://ror.org/00f1zfq44"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411960244.pdf","grobid_xml":"https://content.openalex.org/works/W4411960244.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1989296116","https://openalex.org/W1993548347","https://openalex.org/W2006373538","https://openalex.org/W2045435533","https://openalex.org/W2106882534","https://openalex.org/W2115603949","https://openalex.org/W2117924928","https://openalex.org/W2122563582","https://openalex.org/W2134298288","https://openalex.org/W2141286425","https://openalex.org/W2157205823","https://openalex.org/W2172149993","https://openalex.org/W2188223075","https://openalex.org/W2224398381","https://openalex.org/W2252568502","https://openalex.org/W2336828812","https://openalex.org/W2603161682","https://openalex.org/W2726053863","https://openalex.org/W2766599608","https://openalex.org/W2781931843","https://openalex.org/W2787206763","https://openalex.org/W2793309516","https://openalex.org/W2810756255","https://openalex.org/W2973312556","https://openalex.org/W2981137429","https://openalex.org/W2984059576","https://openalex.org/W3005962315","https://openalex.org/W3034029360","https://openalex.org/W3088092039","https://openalex.org/W3115890771","https://openalex.org/W3134782704","https://openalex.org/W3194399644","https://openalex.org/W4211054902","https://openalex.org/W4293094353","https://openalex.org/W4303859614","https://openalex.org/W4312197262","https://openalex.org/W4316466738","https://openalex.org/W4317437864","https://openalex.org/W4327550249","https://openalex.org/W4388821703","https://openalex.org/W4404525423","https://openalex.org/W4406260670","https://openalex.org/W4408734507","https://openalex.org/W4408762886","https://openalex.org/W6748281036","https://openalex.org/W6751476026"],"related_works":["https://openalex.org/W4366822718","https://openalex.org/W4311501380","https://openalex.org/W2603161682","https://openalex.org/W2807464733","https://openalex.org/W2516842346","https://openalex.org/W2903635918","https://openalex.org/W2437118042","https://openalex.org/W3052741125","https://openalex.org/W2466284841","https://openalex.org/W2357872089"],"abstract_inverted_index":{"The":[0],"source":[1],"code":[2],"can":[3],"be":[4],"obtained":[5],"from":[6],"https://github.com/CSUBioGroup/PLM-CRISPR.":[7]},"counts_by_year":[{"year":2025,"cited_by_count":5}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}
