{"id":"https://openalex.org/W4411994629","doi":"https://doi.org/10.1093/bioinformatics/btaf353","title":"DOSE-L1000-Viz: an interactive Shiny application for dose\u2013response transcriptomic analysis, target-centric exploration, and signature search","display_name":"DOSE-L1000-Viz: an interactive Shiny application for dose\u2013response transcriptomic analysis, target-centric exploration, and signature search","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411994629","doi":"https://doi.org/10.1093/bioinformatics/btaf353","pmid":"https://pubmed.ncbi.nlm.nih.gov/40608961"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf353","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf353/63662114/btaf353.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf353/63662114/btaf353.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100608822","display_name":"Junmin Wang","orcid":"https://orcid.org/0009-0004-3728-9538"},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]},{"id":"https://openalex.org/I4210092243","display_name":"AstraZeneca (South Korea)","ror":"https://ror.org/00h1xaa75","country_code":"KR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210092243"]},{"id":"https://openalex.org/I4210109524","display_name":"AstraZeneca (Australia)","ror":"https://ror.org/018nw3344","country_code":"AU","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210109524"]}],"countries":["AU","BR","KR","US"],"is_corresponding":true,"raw_author_name":"Junmin Wang","raw_affiliation_strings":["Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca , Waltham, MA 02451,","Biopharmaceuticals R&D, AstraZeneca Data Sciences and Quantitative Biology, Discovery Sciences, , Waltham, MA 02451,"],"affiliations":[{"raw_affiliation_string":"Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca , Waltham, MA 02451,","institution_ids":["https://openalex.org/I4210092243","https://openalex.org/I4210109524","https://openalex.org/I4210116875"]},{"raw_affiliation_string":"Biopharmaceuticals R&D, AstraZeneca Data Sciences and Quantitative Biology, Discovery Sciences, , Waltham, MA 02451,","institution_ids":["https://openalex.org/I4210150756"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100608822"],"corresponding_institution_ids":["https://openalex.org/I4210092243","https://openalex.org/I4210109524","https://openalex.org/I4210116875","https://openalex.org/I4210150756"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17650231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6835201382637024},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.6198450326919556},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.6064181327819824},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.5244120359420776},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5187680721282959},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.4699195623397827},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4426216781139374},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.4134998321533203},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37424159049987793},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.2912817895412445},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1804766058921814},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14596760272979736},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13074299693107605},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1241719126701355},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.11924639344215393},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08191731572151184}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6835201382637024},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.6198450326919556},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.6064181327819824},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5244120359420776},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5187680721282959},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.4699195623397827},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4426216781139374},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4134998321533203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37424159049987793},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.2912817895412445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1804766058921814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14596760272979736},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13074299693107605},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1241719126701355},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.11924639344215393},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08191731572151184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf353","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf353/63662114/btaf353.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40608961","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40608961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12237504","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12237504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf353","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf353/63662114/btaf353.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411994629.pdf","grobid_xml":"https://content.openalex.org/works/W4411994629.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1969973975","https://openalex.org/W2021225507","https://openalex.org/W2059005938","https://openalex.org/W2114055071","https://openalex.org/W2321711202","https://openalex.org/W2489003193","https://openalex.org/W2612467560","https://openalex.org/W2791340464","https://openalex.org/W2923151577","https://openalex.org/W2949311246","https://openalex.org/W2973216672","https://openalex.org/W2991157178","https://openalex.org/W3093286766","https://openalex.org/W3182778314","https://openalex.org/W4254687493","https://openalex.org/W4306956709","https://openalex.org/W4388641475","https://openalex.org/W4392284238","https://openalex.org/W4410019487"],"related_works":["https://openalex.org/W1976073696","https://openalex.org/W3165804307","https://openalex.org/W3184846108","https://openalex.org/W4393150518","https://openalex.org/W4401798419","https://openalex.org/W2399513595","https://openalex.org/W3015936091","https://openalex.org/W2122958656","https://openalex.org/W4388386498","https://openalex.org/W1985093619"],"abstract_inverted_index":{"DOSE-L1000-Viz":[0],"and":[1,18],"the":[2],"backend":[3],"data":[4],"are":[5],"publicly":[6,13],"accessible":[7],"at:":[8],"https://dosel1000.com.":[9],"All":[10],"code":[11],"is":[12],"hosted":[14],"on":[15],"GitHub":[16],"(https://github.com/JmWangBio/DOSEL1000Viz)":[17],"archived":[19],"via":[20],"Zenodo":[21],"(https://doi.org/10.5281/zenodo.15532392).":[22]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}