{"id":"https://openalex.org/W4412454095","doi":"https://doi.org/10.1093/bioinformatics/btaf197","title":"Precise prediction of hotspot residues in protein\u2013RNA complexes using graph attention networks and pretrained protein language models","display_name":"Precise prediction of hotspot residues in protein\u2013RNA complexes using graph attention networks and pretrained protein language models","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412454095","doi":"https://doi.org/10.1093/bioinformatics/btaf197","pmid":"https://pubmed.ncbi.nlm.nih.gov/40662818"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf197","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf197","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/41/Supplement_1/i466/63745571/btaf197.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/41/Supplement_1/i466/63745571/btaf197.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101980692","display_name":"Siyuan Shen","orcid":"https://orcid.org/0009-0005-3752-2368"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Shen","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha, 410083,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333028","display_name":"Jie Chen","orcid":"https://orcid.org/0009-0002-9072-9227"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["School of Software, Xinjiang University , Urumqi, 830046,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Xinjiang University , Urumqi, 830046,","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111551491","display_name":"Zhijian Huang","orcid":"https://orcid.org/0009-0000-1949-167X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijian Huang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha, 410083,"],"raw_orcid":"https://orcid.org/0009-0000-1949-167X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052229178","display_name":"Yuanpeng Zhang","orcid":"https://orcid.org/0000-0003-1736-3425"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanpeng Zhang","raw_affiliation_strings":["School of Software, Xinjiang University , Urumqi, 830046,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Xinjiang University , Urumqi, 830046,","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056400750","display_name":"Ziyu Fan","orcid":"https://orcid.org/0009-0003-1962-8092"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyu Fan","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha, 410083,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuting Kong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111575","display_name":"Xinjiang Institute of Engineering","ror":"https://ror.org/01s5hh873","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210111575","https://openalex.org/I4210157944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Kong","raw_affiliation_strings":["School of Information Engineering, Xinjiang Institute of Engineering , Urumqi, 830023,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Engineering, Xinjiang Institute of Engineering , Urumqi, 830023,","institution_ids":["https://openalex.org/I4210111575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University , Changsha, 410083,"],"raw_orcid":"https://orcid.org/0000-0003-2869-1619","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University , Changsha, 410083,","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13388477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"Supplement_1","first_page":"i466","last_page":"i474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7335000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7335000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.12030000239610672,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hotspot","display_name":"Hotspot (geology)","score":0.7257627248764038},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7231330871582031},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.46940314769744873},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4597521126270294},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4058113396167755},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4013672173023224},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35336828231811523},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3365876078605652},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3347688913345337},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13673245906829834},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1224321722984314}],"concepts":[{"id":"https://openalex.org/C146481406","wikidata":"https://www.wikidata.org/wiki/Q105131","display_name":"Hotspot (geology)","level":2,"score":0.7257627248764038},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7231330871582031},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.46940314769744873},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4597521126270294},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4058113396167755},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4013672173023224},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35336828231811523},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3365876078605652},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3347688913345337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13673245906829834},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1224321722984314},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C8058405","wikidata":"https://www.wikidata.org/wiki/Q46255","display_name":"Geophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf197","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf197","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/41/Supplement_1/i466/63745571/btaf197.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40662818","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40662818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12261489","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12261489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf197","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf197","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/41/Supplement_1/i466/63745571/btaf197.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2008773563","display_name":null,"funder_award_id":"62272490","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5299854802","display_name":null,"funder_award_id":"U23A20321","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412454095.pdf","grobid_xml":"https://content.openalex.org/works/W4412454095.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1408885899","https://openalex.org/W1588341390","https://openalex.org/W1998645872","https://openalex.org/W2008056655","https://openalex.org/W2008708467","https://openalex.org/W2051710717","https://openalex.org/W2058527555","https://openalex.org/W2062617571","https://openalex.org/W2076048958","https://openalex.org/W2085902776","https://openalex.org/W2092387745","https://openalex.org/W2099207820","https://openalex.org/W2102245393","https://openalex.org/W2116211618","https://openalex.org/W2137840425","https://openalex.org/W2144009034","https://openalex.org/W2150192011","https://openalex.org/W2153187042","https://openalex.org/W2157735020","https://openalex.org/W2158714788","https://openalex.org/W2165054672","https://openalex.org/W2166186928","https://openalex.org/W2777941847","https://openalex.org/W2810018398","https://openalex.org/W2911964244","https://openalex.org/W2919115771","https://openalex.org/W2924197217","https://openalex.org/W3106930452","https://openalex.org/W3126876258","https://openalex.org/W3146366485","https://openalex.org/W3147254695","https://openalex.org/W3188212317","https://openalex.org/W4214910487","https://openalex.org/W4281706128","https://openalex.org/W4327550249","https://openalex.org/W4382632527"],"related_works":["https://openalex.org/W2379637199","https://openalex.org/W4406532822","https://openalex.org/W2405057786","https://openalex.org/W2501832907","https://openalex.org/W2063054109","https://openalex.org/W2079602762","https://openalex.org/W2580355466","https://openalex.org/W1888682135","https://openalex.org/W2765519165","https://openalex.org/W1994086845"],"abstract_inverted_index":{"MOTIVATION:":[0],"Protein-RNA":[1],"interactions":[2],"play":[3],"a":[4,79,93,143,153],"pivotal":[5],"role":[6],"in":[7,69,88,170],"biological":[8],"processes":[9,120],"and":[10,32,60,102,137,186],"disease":[11],"mechanisms,":[12],"with":[13,173],"hotspot":[14,27,67,86,149,168],"residues":[15,28,68,87,169],"being":[16],"critical":[17],"for":[18,25,57,65],"targeted":[19],"drug":[20],"design.":[21],"Traditional":[22],"experimental":[23],"methods":[24,38],"identifying":[26,167],"are":[29,188],"often":[30],"inefficient":[31],"expensive.":[33],"Moreover,":[34],"many":[35],"existing":[36],"prediction":[37,151],"rely":[39],"heavily":[40],"on":[41,176],"high-resolution":[42],"structural":[43],"data,":[44],"which":[45,119],"may":[46],"not":[47],"always":[48],"be":[49],"available.":[50],"Consequently,":[51],"there":[52],"is":[53],"an":[54,58,104,128],"urgent":[55],"need":[56],"accurate":[59],"efficient":[61],"sequence-based":[62,80],"computational":[63,81],"approach":[64],"predicting":[66],"protein-RNA":[70,89,171],"complexes.":[71,90],"RESULTS:":[72],"In":[73],"this":[74],"study,":[75],"we":[76],"introduce":[77],"DeepHotResi,":[78],"method":[82],"designed":[83],"to":[84,98,147],"predict":[85,99],"DeepHotResi":[91,113,141,162],"leverages":[92],"pretrained":[94],"protein":[95,100],"language":[96],"model":[97,148],"structure":[101],"generate":[103],"amino":[105,122,129],"acid":[106,130],"contact":[107,135],"map.":[108],"To":[109],"enhance":[110],"feature":[111,131],"representation,":[112],"integrates":[114],"the":[115,134,177],"Squeeze-and-Excitation":[116],"(SE)":[117],"module,":[118],"diverse":[121],"acid-level":[123],"features.":[124,139],"Next,":[125],"it":[126],"constructs":[127],"network":[132,146],"from":[133],"map":[136],"SE-module-derived":[138],"Finally,":[140],"employs":[142],"graph":[144,154],"attention":[145],"residue":[150],"as":[152],"node":[155],"classification":[156],"task.":[157],"Experimental":[158],"results":[159],"demonstrate":[160],"that":[161],"outperforms":[163],"state-of-the-art":[164],"methods,":[165],"effectively":[166],"complexes":[172],"superior":[174],"accuracy":[175],"test":[178],"set.":[179],"AVAILABILITY":[180],"AND":[181],"IMPLEMENTATION:":[182],"The":[183],"source":[184],"code":[185],"dataset":[187],"available":[189],"at":[190],"https://github.com/Q1DT/DeepHotResi.":[191]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}