{"id":"https://openalex.org/W4407638313","doi":"https://doi.org/10.1093/bioinformatics/btaf074","title":"GCLink: a graph contrastive link prediction framework for gene regulatory network inference","display_name":"GCLink: a graph contrastive link prediction framework for gene regulatory network inference","publication_year":2025,"publication_date":"2025-02-17","ids":{"openalex":"https://openalex.org/W4407638313","doi":"https://doi.org/10.1093/bioinformatics/btaf074","pmid":"https://pubmed.ncbi.nlm.nih.gov/39960893"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaf074","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf074","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf074/61932825/btaf074.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf074/61932825/btaf074.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065833423","display_name":"Weiming Yu","orcid":"https://orcid.org/0000-0002-3024-2938"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Yu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080181019","display_name":"Zerun Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zerun Lin","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miaofang Lan","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miaofang Lan","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060,","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security, College of Electronics and Information Engineering, Shenzhen University, Shenzhen, 518060, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030129372","display_name":"Le Ou-Yang","orcid":"https://orcid.org/0000-0003-4007-4568"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210152380","display_name":"Shenzhen Technology University","ror":"https://ror.org/04qzpec27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152380"]},{"id":"https://openalex.org/I4388482657","display_name":"Shenzhen MSU-BIT University","ror":"https://ror.org/02q963474","country_code":null,"type":"education","lineage":["https://openalex.org/I4388482657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Le Ou-Yang","raw_affiliation_strings":["Guangdong Laboratory of Machine Perception and Intelligent Computing, Faculty of Engineering, Shenzhen MSU-BIT University , Shenzhen 518116,","Guangdong Laboratory of Machine Perception and Intelligent Computing, Faculty of Engineering, Shenzhen MSU-BIT University, Shenzhen, 518116, China"],"raw_orcid":"https://orcid.org/0000-0003-4007-4568","affiliations":[{"raw_affiliation_string":"Guangdong Laboratory of Machine Perception and Intelligent Computing, Faculty of Engineering, Shenzhen MSU-BIT University , Shenzhen 518116,","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210152380"]},{"raw_affiliation_string":"Guangdong Laboratory of Machine Perception and Intelligent Computing, Faculty of Engineering, Shenzhen MSU-BIT University, Shenzhen, 518116, China","institution_ids":["https://openalex.org/I4388482657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030129372"],"corresponding_institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210152380","https://openalex.org/I4388482657"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":3.6812,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.93183448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"41","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.7652000188827515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.7652000188827515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7649666666984558},{"id":"https://openalex.org/keywords/link","display_name":"Link (geometry)","score":0.6413403153419495},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5963261723518372},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5917513370513916},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5624370574951172},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4085279405117035},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33741140365600586},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33203160762786865},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2563459277153015},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24386218190193176},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22833946347236633},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.15857145190238953},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.100348562002182}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7649666666984558},{"id":"https://openalex.org/C2778753846","wikidata":"https://www.wikidata.org/wiki/Q6554239","display_name":"Link (geometry)","level":2,"score":0.6413403153419495},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5963261723518372},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5917513370513916},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5624370574951172},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4085279405117035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33741140365600586},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33203160762786865},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2563459277153015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24386218190193176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22833946347236633},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.15857145190238953},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.100348562002182}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btaf074","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf074","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf074/61932825/btaf074.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39960893","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39960893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11881698","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11881698","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaf074","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaf074","pdf_url":"https://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btaf074/61932825/btaf074.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1888855023","display_name":null,"funder_award_id":"2022ZDZX1022","funder_id":"https://openalex.org/F4320326279","funder_display_name":"Department of Education of Guangdong Province"},{"id":"https://openalex.org/G1957408769","display_name":null,"funder_award_id":"62173235","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3516314601","display_name":null,"funder_award_id":"62473266","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6698629912","display_name":null,"funder_award_id":"2024B1515020059","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326279","display_name":"Department of Education of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407638313.pdf","grobid_xml":"https://content.openalex.org/works/W4407638313.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1580018887","https://openalex.org/W1967327758","https://openalex.org/W2057306408","https://openalex.org/W2076513103","https://openalex.org/W2109384743","https://openalex.org/W2140258573","https://openalex.org/W2462053388","https://openalex.org/W2465917013","https://openalex.org/W2561884319","https://openalex.org/W2626990934","https://openalex.org/W2757234574","https://openalex.org/W2789254933","https://openalex.org/W2886347923","https://openalex.org/W2900569176","https://openalex.org/W2901292166","https://openalex.org/W2951424836","https://openalex.org/W2963757395","https://openalex.org/W2964315448","https://openalex.org/W2996140569","https://openalex.org/W2997831639","https://openalex.org/W3045910546","https://openalex.org/W3095602948","https://openalex.org/W3127245931","https://openalex.org/W3142178348","https://openalex.org/W3186348651","https://openalex.org/W3193795275","https://openalex.org/W4290930137","https://openalex.org/W4297733535","https://openalex.org/W4309305894","https://openalex.org/W4313340543","https://openalex.org/W4320855961","https://openalex.org/W4362460300","https://openalex.org/W4386699707","https://openalex.org/W4388870182","https://openalex.org/W4394014672","https://openalex.org/W4400456388","https://openalex.org/W6719894144","https://openalex.org/W6745537798","https://openalex.org/W6748856961","https://openalex.org/W6784694379"],"related_works":["https://openalex.org/W1518185400","https://openalex.org/W3200586296","https://openalex.org/W4230332972","https://openalex.org/W1998033311","https://openalex.org/W4247322236","https://openalex.org/W2950199998","https://openalex.org/W2560421304","https://openalex.org/W2951387065","https://openalex.org/W4385727351","https://openalex.org/W4306798985"],"abstract_inverted_index":{"MOTIVATION:":[0],"Gene":[1],"regulatory":[2,49,83,92,136,166],"networks":[3],"(GRNs)":[4],"unveil":[5],"the":[6,14,27,35,106,120],"intricate":[7],"interactions":[8,84,93,167],"among":[9,57],"genes,":[10],"pivotal":[11],"in":[12,132,151,188,194],"elucidating":[13],"complex":[15],"biological":[16],"processes":[17],"within":[18],"cells.":[19],"The":[20,206],"advent":[21],"of":[22,29,37,111,122,179],"single-cell":[23,32],"RNA-sequencing":[24],"(scRNA-seq)":[25],"enables":[26],"inference":[28,41],"GRNs":[30,196],"at":[31,213],"resolution.":[33],"However,":[34],"majority":[36],"current":[38],"supervised":[39],"network":[40],"methods":[42,150],"typically":[43],"concentrate":[44],"on":[45,89,125,140,158,171],"predicting":[46,133],"pairwise":[47],"gene":[48,82,91,135],"interaction,":[50],"thus":[51],"failing":[52],"to":[53,79,104,113],"fully":[54],"exploit":[55],"correlations":[56],"all":[58],"genes":[59,112],"and":[60,94,108,128,168,209],"exhibiting":[61],"limited":[62,177,200],"generalization":[63],"performance.":[64],"RESULTS:":[65],"To":[66],"address":[67],"these":[68],"issues,":[69],"we":[70],"propose":[71],"a":[72,99,159,172],"graph":[73,100],"contrastive":[74,101],"link":[75],"prediction":[76],"(GCLink)":[77],"model":[78,124,184],"infer":[80],"potential":[81,134],"from":[85,197],"scRNA-seq":[86,95,142],"data.":[87],"Based":[88],"known":[90,165,180,201],"data,":[96],"GCLink":[97,146,157,183],"introduces":[98],"learning":[102],"strategy":[103],"aggregate":[105],"feature":[107],"neighborhood":[109],"information":[110],"learn":[114],"their":[115],"representations.":[116],"This":[117],"approach":[118],"reduces":[119],"dependence":[121],"our":[123,182],"sample":[126],"size":[127],"enhance":[129],"its":[130,192],"ability":[131],"interactions.":[137,202],"Extensive":[138],"experiments":[139],"real":[141],"datasets":[143,198],"demonstrate":[144],"that":[145],"outperforms":[147],"other":[148],"state-of-the-art":[149],"most":[152],"cases.":[153],"Furthermore,":[154],"by":[155],"pretraining":[156],"source":[160,207],"cell":[161,174],"line":[162,175],"with":[163,176,199],"abundant":[164],"fine-tuning":[169],"it":[170],"target":[173],"amount":[178],"interactions,":[181],"exhibits":[185],"good":[186],"performance":[187],"GRN":[189],"inference,":[190],"demonstrating":[191],"effectiveness":[193],"inferring":[195],"AVAILABILITY":[203],"AND":[204],"IMPLEMENTATION:":[205],"code":[208],"data":[210],"are":[211],"available":[212],"https://github.com/Yoyiming/GCLink.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}
